Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/19880 |
Resumo: | Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have emerged as promising strategies to regenerate damaged cardiac tissue and restore cardiac function. Moreover, the generation of human induced pluripotent stem cells (iPSCs) from somatic cells has opened new avenues for disease modeling, drug discovery, and regenerative medicine applications, with fewer ethical concerns than those associated with ESCs. Herein, we provide a state-of-the-art review on the application of human pluripotent stem cells in CVD research and clinics. We describe the types and sources of stem cells that have been tested in preclinical and clinical trials for the treatment of CVDs as well as the applications of pluripotent stem-cell-derived in vitro systems to mimic disease phenotypes. How human stem-cell-based in vitro systems can overcome the limitations of current toxicological studies is also discussed. Finally, the current state of clinical trials involving stem-cell-based approaches to treat CVDs are presented, and the strengths and weaknesses are critically discussed to assess whether researchers and clinicians are getting closer to success. |
id |
RCAP_e45442902b17c7535df4db13870f2cd0 |
---|---|
oai_identifier_str |
oai:sapientia.ualg.pt:10400.1/19880 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?Human stem cellsCardiovascular diseasesiPSCDisease modelingCell therapyCardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have emerged as promising strategies to regenerate damaged cardiac tissue and restore cardiac function. Moreover, the generation of human induced pluripotent stem cells (iPSCs) from somatic cells has opened new avenues for disease modeling, drug discovery, and regenerative medicine applications, with fewer ethical concerns than those associated with ESCs. Herein, we provide a state-of-the-art review on the application of human pluripotent stem cells in CVD research and clinics. We describe the types and sources of stem cells that have been tested in preclinical and clinical trials for the treatment of CVDs as well as the applications of pluripotent stem-cell-derived in vitro systems to mimic disease phenotypes. How human stem-cell-based in vitro systems can overcome the limitations of current toxicological studies is also discussed. Finally, the current state of clinical trials involving stem-cell-based approaches to treat CVDs are presented, and the strengths and weaknesses are critically discussed to assess whether researchers and clinicians are getting closer to success.B.M.S. was awarded with a Ph.D. fellowship (reference: 2022.13253.BDANA) by Fundação para a Ciência e Tecnologia (FCT). S.M.C is supported by a Stimulus of Scientific Employment, Individual Support (2020.01532.CEECIND) by FCT. J.B. is grateful to the FCT and the Comissão de Coordenação e Desenvolvimento Regional do Algarve (CCDR Algarve) for the project ALG-45-2020-41 and to Algarve Biomedical Center (ABC) for the award “Bolsa de Investigação Translacional—José Mariano Gago by ABC, 2022”. M.T.F. thanks the FCT for funding the project with the reference 2022.09209.PTDC.MDPISapientiaCorreia, CátiaFerreira, AnitaFernandes, Mónica T.Silva, Bárbara M.Esteves, FilipaLeitao, HelenaBragança, JoséCalado, Sofia2023-07-27T14:44:06Z2023-06-272023-07-13T14:06:57Z2023-06-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/19880engCells 12 (13): 1727 (2023)2073-440910.3390/cells12131727info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-02T02:02:02Zoai:sapientia.ualg.pt:10400.1/19880Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:10:25.353131Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? |
title |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? |
spellingShingle |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? Correia, Cátia Human stem cells Cardiovascular diseases iPSC Disease modeling Cell therapy |
title_short |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? |
title_full |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? |
title_fullStr |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? |
title_full_unstemmed |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? |
title_sort |
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success? |
author |
Correia, Cátia |
author_facet |
Correia, Cátia Ferreira, Anita Fernandes, Mónica T. Silva, Bárbara M. Esteves, Filipa Leitao, Helena Bragança, José Calado, Sofia |
author_role |
author |
author2 |
Ferreira, Anita Fernandes, Mónica T. Silva, Bárbara M. Esteves, Filipa Leitao, Helena Bragança, José Calado, Sofia |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Correia, Cátia Ferreira, Anita Fernandes, Mónica T. Silva, Bárbara M. Esteves, Filipa Leitao, Helena Bragança, José Calado, Sofia |
dc.subject.por.fl_str_mv |
Human stem cells Cardiovascular diseases iPSC Disease modeling Cell therapy |
topic |
Human stem cells Cardiovascular diseases iPSC Disease modeling Cell therapy |
description |
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have emerged as promising strategies to regenerate damaged cardiac tissue and restore cardiac function. Moreover, the generation of human induced pluripotent stem cells (iPSCs) from somatic cells has opened new avenues for disease modeling, drug discovery, and regenerative medicine applications, with fewer ethical concerns than those associated with ESCs. Herein, we provide a state-of-the-art review on the application of human pluripotent stem cells in CVD research and clinics. We describe the types and sources of stem cells that have been tested in preclinical and clinical trials for the treatment of CVDs as well as the applications of pluripotent stem-cell-derived in vitro systems to mimic disease phenotypes. How human stem-cell-based in vitro systems can overcome the limitations of current toxicological studies is also discussed. Finally, the current state of clinical trials involving stem-cell-based approaches to treat CVDs are presented, and the strengths and weaknesses are critically discussed to assess whether researchers and clinicians are getting closer to success. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-27T14:44:06Z 2023-06-27 2023-07-13T14:06:57Z 2023-06-27T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/19880 |
url |
http://hdl.handle.net/10400.1/19880 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cells 12 (13): 1727 (2023) 2073-4409 10.3390/cells12131727 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133354042327040 |