The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/27423 |
Resumo: | Little is known about the consequences of exposure to pharmaceuticals and personal care products (PPCPs) in elevated temperatures associated with climate change. To increase the knowledge on this topic, Mytilus galloprovincialis mussels were exposed to 1.0 µg/L of either the antimicrobial Triclosan (TCS) or the pharmaceutical drug Diclofenac (DIC), at control (17ºC) and 4ºC raised (21ºC) temperatures for 28 days. Triclosan and DIC concentrations in the water and tissues were subsequently measured and related to biomarker responses including: energy metabolism (electron transport system (ETS) activity, glycogen and protein reserves), oxidative stress markers, glutathione balance between the reduced and the oxidised form (GSH/GSSG), and damage to proteins and lipids. Mussels responded to the increase in temperature and drug exposure by lowering their metabolic rate (decreased ETS), increasing their endogenous reserves and antioxidant defences, thus preventing oxidative stress damage, with the exception of DIC exposure at the higher temperature. In all cases, GSH/GSSG ratio was reduced in detriment of the antioxidant form at both PPCPs exposures and elevated temperature with no additive effect due to combined stressors. Overall, either drug exposure or increased temperature could compromise the ability of mussels to withstand further insults. |
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The influence of temperature on the effects induced by Triclosan and Diclofenac in musselsClimate changePharmaceuticalsPersonal care productsBiomarkersBivalvesMytilus galloprovincialisLittle is known about the consequences of exposure to pharmaceuticals and personal care products (PPCPs) in elevated temperatures associated with climate change. To increase the knowledge on this topic, Mytilus galloprovincialis mussels were exposed to 1.0 µg/L of either the antimicrobial Triclosan (TCS) or the pharmaceutical drug Diclofenac (DIC), at control (17ºC) and 4ºC raised (21ºC) temperatures for 28 days. Triclosan and DIC concentrations in the water and tissues were subsequently measured and related to biomarker responses including: energy metabolism (electron transport system (ETS) activity, glycogen and protein reserves), oxidative stress markers, glutathione balance between the reduced and the oxidised form (GSH/GSSG), and damage to proteins and lipids. Mussels responded to the increase in temperature and drug exposure by lowering their metabolic rate (decreased ETS), increasing their endogenous reserves and antioxidant defences, thus preventing oxidative stress damage, with the exception of DIC exposure at the higher temperature. In all cases, GSH/GSSG ratio was reduced in detriment of the antioxidant form at both PPCPs exposures and elevated temperature with no additive effect due to combined stressors. Overall, either drug exposure or increased temperature could compromise the ability of mussels to withstand further insults.Elsevier2020-05-02T00:00:00Z2019-05-01T00:00:00Z2019-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/27423eng0048-9697https://doi.org/10.1016/j.scitotenv.2019.01.189Freitas, RosaCoppola, FrancescaCosta, SilvanaPretti, CarloIntorre, LuigiMeucci, ValentinaSoares, Amadeu M. V. M.Solé, Montserratinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:53:03Zoai:ria.ua.pt:10773/27423Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:11.150739Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels |
title |
The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels |
spellingShingle |
The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels Freitas, Rosa Climate change Pharmaceuticals Personal care products Biomarkers Bivalves Mytilus galloprovincialis |
title_short |
The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels |
title_full |
The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels |
title_fullStr |
The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels |
title_full_unstemmed |
The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels |
title_sort |
The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels |
author |
Freitas, Rosa |
author_facet |
Freitas, Rosa Coppola, Francesca Costa, Silvana Pretti, Carlo Intorre, Luigi Meucci, Valentina Soares, Amadeu M. V. M. Solé, Montserrat |
author_role |
author |
author2 |
Coppola, Francesca Costa, Silvana Pretti, Carlo Intorre, Luigi Meucci, Valentina Soares, Amadeu M. V. M. Solé, Montserrat |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Freitas, Rosa Coppola, Francesca Costa, Silvana Pretti, Carlo Intorre, Luigi Meucci, Valentina Soares, Amadeu M. V. M. Solé, Montserrat |
dc.subject.por.fl_str_mv |
Climate change Pharmaceuticals Personal care products Biomarkers Bivalves Mytilus galloprovincialis |
topic |
Climate change Pharmaceuticals Personal care products Biomarkers Bivalves Mytilus galloprovincialis |
description |
Little is known about the consequences of exposure to pharmaceuticals and personal care products (PPCPs) in elevated temperatures associated with climate change. To increase the knowledge on this topic, Mytilus galloprovincialis mussels were exposed to 1.0 µg/L of either the antimicrobial Triclosan (TCS) or the pharmaceutical drug Diclofenac (DIC), at control (17ºC) and 4ºC raised (21ºC) temperatures for 28 days. Triclosan and DIC concentrations in the water and tissues were subsequently measured and related to biomarker responses including: energy metabolism (electron transport system (ETS) activity, glycogen and protein reserves), oxidative stress markers, glutathione balance between the reduced and the oxidised form (GSH/GSSG), and damage to proteins and lipids. Mussels responded to the increase in temperature and drug exposure by lowering their metabolic rate (decreased ETS), increasing their endogenous reserves and antioxidant defences, thus preventing oxidative stress damage, with the exception of DIC exposure at the higher temperature. In all cases, GSH/GSSG ratio was reduced in detriment of the antioxidant form at both PPCPs exposures and elevated temperature with no additive effect due to combined stressors. Overall, either drug exposure or increased temperature could compromise the ability of mussels to withstand further insults. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05-01T00:00:00Z 2019-05-01 2020-05-02T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/27423 |
url |
http://hdl.handle.net/10773/27423 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0048-9697 https://doi.org/10.1016/j.scitotenv.2019.01.189 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137656718753792 |