Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis

Detalhes bibliográficos
Autor(a) principal: Henriques, Bruno
Data de Publicação: 2019
Outros Autores: Coppola, Francesca, Monteiro, Rui, Pinto, João, Viana, Thainara, Pretti, Carlo, Soares, Amadeu M. V. M., Freitas, Rosa, Pereira, Eduarda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/27425
Resumo: Recently, anthropogenic enrichment of rare earth elements (REE) have been reported in natural environments, due to increasing use and discharges of hospital/industrial wastewaters. Gadolinium (Gd), which is mainly used as contrast agent for magnetic resonance imaging in medical exams, may reach concentrations in water up to two orders of magnitude larger than baseline levels. Nevertheless, in marine systems scarce information is available concerning the toxicity of REE towards inhabiting organisms. This study aimed to evaluate the biochemical impact of anthropogenic Gd in the Mediterranean mussel Mytilus galloprovincialis, which is a species of commercial interest and one of the most accepted pollution bioindicator. Organisms were exposed to different concentrations of Gd (0, 15, 30, 60, 120 µg/L) for 28 days. At the end of the experiments, biomarkers related to mussels’ metabolic (electron transport system activity and energy reserves content), oxidative stress status (cellular damage and the activity of antioxidant and biotransformation enzymes) and neurotoxic effects (activity of the enzyme Acetylcholinesterase) were measured, as well as Gd bioconcentration in organisms. Results showed a high content of Gd (2.5±0.50 µg/g) in mussels exposed to the highest concentration, contrary to those at control condition and at 15 and 30 μg/L of Gd (levels below 0.38 µg/g). Although no mortality was observed during the experimental period, exposure to Gd strongly affected the biochemical performance of M. galloprovincialis, including the decrease on mussels’ metabolism, induction of oxidative stress and neurotoxicity, particularly evidenced at intermediate concentrations. These results may indicate that up to certain stressful levels, although lowering their metabolism, organisms may be able to activate defense strategies to avoid cellular injuries which, on the other hand, may compromise mussels physiological performance such as growth and reproduction success. Nevertheless, our findings support that the widespread utilization of Gd may represent an environmental risk in the future.
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spelling Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialisRare earth elementsMytilus galloprovincialisBioaccumulationMetabolismsOxidative stressNeurotoxicityRecently, anthropogenic enrichment of rare earth elements (REE) have been reported in natural environments, due to increasing use and discharges of hospital/industrial wastewaters. Gadolinium (Gd), which is mainly used as contrast agent for magnetic resonance imaging in medical exams, may reach concentrations in water up to two orders of magnitude larger than baseline levels. Nevertheless, in marine systems scarce information is available concerning the toxicity of REE towards inhabiting organisms. This study aimed to evaluate the biochemical impact of anthropogenic Gd in the Mediterranean mussel Mytilus galloprovincialis, which is a species of commercial interest and one of the most accepted pollution bioindicator. Organisms were exposed to different concentrations of Gd (0, 15, 30, 60, 120 µg/L) for 28 days. At the end of the experiments, biomarkers related to mussels’ metabolic (electron transport system activity and energy reserves content), oxidative stress status (cellular damage and the activity of antioxidant and biotransformation enzymes) and neurotoxic effects (activity of the enzyme Acetylcholinesterase) were measured, as well as Gd bioconcentration in organisms. Results showed a high content of Gd (2.5±0.50 µg/g) in mussels exposed to the highest concentration, contrary to those at control condition and at 15 and 30 μg/L of Gd (levels below 0.38 µg/g). Although no mortality was observed during the experimental period, exposure to Gd strongly affected the biochemical performance of M. galloprovincialis, including the decrease on mussels’ metabolism, induction of oxidative stress and neurotoxicity, particularly evidenced at intermediate concentrations. These results may indicate that up to certain stressful levels, although lowering their metabolism, organisms may be able to activate defense strategies to avoid cellular injuries which, on the other hand, may compromise mussels physiological performance such as growth and reproduction success. Nevertheless, our findings support that the widespread utilization of Gd may represent an environmental risk in the future.Elsevier2020-05-11T00:00:00Z2019-05-10T00:00:00Z2019-05-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/27425eng0048-9697https://doi.org/10.1016/j.scitotenv.2019.01.341Henriques, BrunoCoppola, FrancescaMonteiro, RuiPinto, JoãoViana, ThainaraPretti, CarloSoares, Amadeu M. V. M.Freitas, RosaPereira, Eduardainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:53:04Zoai:ria.ua.pt:10773/27425Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:11.202979Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
title Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
spellingShingle Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
Henriques, Bruno
Rare earth elements
Mytilus galloprovincialis
Bioaccumulation
Metabolisms
Oxidative stress
Neurotoxicity
title_short Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
title_full Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
title_fullStr Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
title_full_unstemmed Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
title_sort Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
author Henriques, Bruno
author_facet Henriques, Bruno
Coppola, Francesca
Monteiro, Rui
Pinto, João
Viana, Thainara
Pretti, Carlo
Soares, Amadeu M. V. M.
Freitas, Rosa
Pereira, Eduarda
author_role author
author2 Coppola, Francesca
Monteiro, Rui
Pinto, João
Viana, Thainara
Pretti, Carlo
Soares, Amadeu M. V. M.
Freitas, Rosa
Pereira, Eduarda
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Henriques, Bruno
Coppola, Francesca
Monteiro, Rui
Pinto, João
Viana, Thainara
Pretti, Carlo
Soares, Amadeu M. V. M.
Freitas, Rosa
Pereira, Eduarda
dc.subject.por.fl_str_mv Rare earth elements
Mytilus galloprovincialis
Bioaccumulation
Metabolisms
Oxidative stress
Neurotoxicity
topic Rare earth elements
Mytilus galloprovincialis
Bioaccumulation
Metabolisms
Oxidative stress
Neurotoxicity
description Recently, anthropogenic enrichment of rare earth elements (REE) have been reported in natural environments, due to increasing use and discharges of hospital/industrial wastewaters. Gadolinium (Gd), which is mainly used as contrast agent for magnetic resonance imaging in medical exams, may reach concentrations in water up to two orders of magnitude larger than baseline levels. Nevertheless, in marine systems scarce information is available concerning the toxicity of REE towards inhabiting organisms. This study aimed to evaluate the biochemical impact of anthropogenic Gd in the Mediterranean mussel Mytilus galloprovincialis, which is a species of commercial interest and one of the most accepted pollution bioindicator. Organisms were exposed to different concentrations of Gd (0, 15, 30, 60, 120 µg/L) for 28 days. At the end of the experiments, biomarkers related to mussels’ metabolic (electron transport system activity and energy reserves content), oxidative stress status (cellular damage and the activity of antioxidant and biotransformation enzymes) and neurotoxic effects (activity of the enzyme Acetylcholinesterase) were measured, as well as Gd bioconcentration in organisms. Results showed a high content of Gd (2.5±0.50 µg/g) in mussels exposed to the highest concentration, contrary to those at control condition and at 15 and 30 μg/L of Gd (levels below 0.38 µg/g). Although no mortality was observed during the experimental period, exposure to Gd strongly affected the biochemical performance of M. galloprovincialis, including the decrease on mussels’ metabolism, induction of oxidative stress and neurotoxicity, particularly evidenced at intermediate concentrations. These results may indicate that up to certain stressful levels, although lowering their metabolism, organisms may be able to activate defense strategies to avoid cellular injuries which, on the other hand, may compromise mussels physiological performance such as growth and reproduction success. Nevertheless, our findings support that the widespread utilization of Gd may represent an environmental risk in the future.
publishDate 2019
dc.date.none.fl_str_mv 2019-05-10T00:00:00Z
2019-05-10
2020-05-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/27425
url http://hdl.handle.net/10773/27425
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0048-9697
https://doi.org/10.1016/j.scitotenv.2019.01.341
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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