Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/27425 |
Resumo: | Recently, anthropogenic enrichment of rare earth elements (REE) have been reported in natural environments, due to increasing use and discharges of hospital/industrial wastewaters. Gadolinium (Gd), which is mainly used as contrast agent for magnetic resonance imaging in medical exams, may reach concentrations in water up to two orders of magnitude larger than baseline levels. Nevertheless, in marine systems scarce information is available concerning the toxicity of REE towards inhabiting organisms. This study aimed to evaluate the biochemical impact of anthropogenic Gd in the Mediterranean mussel Mytilus galloprovincialis, which is a species of commercial interest and one of the most accepted pollution bioindicator. Organisms were exposed to different concentrations of Gd (0, 15, 30, 60, 120 µg/L) for 28 days. At the end of the experiments, biomarkers related to mussels’ metabolic (electron transport system activity and energy reserves content), oxidative stress status (cellular damage and the activity of antioxidant and biotransformation enzymes) and neurotoxic effects (activity of the enzyme Acetylcholinesterase) were measured, as well as Gd bioconcentration in organisms. Results showed a high content of Gd (2.5±0.50 µg/g) in mussels exposed to the highest concentration, contrary to those at control condition and at 15 and 30 μg/L of Gd (levels below 0.38 µg/g). Although no mortality was observed during the experimental period, exposure to Gd strongly affected the biochemical performance of M. galloprovincialis, including the decrease on mussels’ metabolism, induction of oxidative stress and neurotoxicity, particularly evidenced at intermediate concentrations. These results may indicate that up to certain stressful levels, although lowering their metabolism, organisms may be able to activate defense strategies to avoid cellular injuries which, on the other hand, may compromise mussels physiological performance such as growth and reproduction success. Nevertheless, our findings support that the widespread utilization of Gd may represent an environmental risk in the future. |
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Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialisRare earth elementsMytilus galloprovincialisBioaccumulationMetabolismsOxidative stressNeurotoxicityRecently, anthropogenic enrichment of rare earth elements (REE) have been reported in natural environments, due to increasing use and discharges of hospital/industrial wastewaters. Gadolinium (Gd), which is mainly used as contrast agent for magnetic resonance imaging in medical exams, may reach concentrations in water up to two orders of magnitude larger than baseline levels. Nevertheless, in marine systems scarce information is available concerning the toxicity of REE towards inhabiting organisms. This study aimed to evaluate the biochemical impact of anthropogenic Gd in the Mediterranean mussel Mytilus galloprovincialis, which is a species of commercial interest and one of the most accepted pollution bioindicator. Organisms were exposed to different concentrations of Gd (0, 15, 30, 60, 120 µg/L) for 28 days. At the end of the experiments, biomarkers related to mussels’ metabolic (electron transport system activity and energy reserves content), oxidative stress status (cellular damage and the activity of antioxidant and biotransformation enzymes) and neurotoxic effects (activity of the enzyme Acetylcholinesterase) were measured, as well as Gd bioconcentration in organisms. Results showed a high content of Gd (2.5±0.50 µg/g) in mussels exposed to the highest concentration, contrary to those at control condition and at 15 and 30 μg/L of Gd (levels below 0.38 µg/g). Although no mortality was observed during the experimental period, exposure to Gd strongly affected the biochemical performance of M. galloprovincialis, including the decrease on mussels’ metabolism, induction of oxidative stress and neurotoxicity, particularly evidenced at intermediate concentrations. These results may indicate that up to certain stressful levels, although lowering their metabolism, organisms may be able to activate defense strategies to avoid cellular injuries which, on the other hand, may compromise mussels physiological performance such as growth and reproduction success. Nevertheless, our findings support that the widespread utilization of Gd may represent an environmental risk in the future.Elsevier2020-05-11T00:00:00Z2019-05-10T00:00:00Z2019-05-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/27425eng0048-9697https://doi.org/10.1016/j.scitotenv.2019.01.341Henriques, BrunoCoppola, FrancescaMonteiro, RuiPinto, JoãoViana, ThainaraPretti, CarloSoares, Amadeu M. V. M.Freitas, RosaPereira, Eduardainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:53:04Zoai:ria.ua.pt:10773/27425Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:11.202979Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis |
title |
Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis |
spellingShingle |
Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis Henriques, Bruno Rare earth elements Mytilus galloprovincialis Bioaccumulation Metabolisms Oxidative stress Neurotoxicity |
title_short |
Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis |
title_full |
Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis |
title_fullStr |
Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis |
title_full_unstemmed |
Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis |
title_sort |
Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis |
author |
Henriques, Bruno |
author_facet |
Henriques, Bruno Coppola, Francesca Monteiro, Rui Pinto, João Viana, Thainara Pretti, Carlo Soares, Amadeu M. V. M. Freitas, Rosa Pereira, Eduarda |
author_role |
author |
author2 |
Coppola, Francesca Monteiro, Rui Pinto, João Viana, Thainara Pretti, Carlo Soares, Amadeu M. V. M. Freitas, Rosa Pereira, Eduarda |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Henriques, Bruno Coppola, Francesca Monteiro, Rui Pinto, João Viana, Thainara Pretti, Carlo Soares, Amadeu M. V. M. Freitas, Rosa Pereira, Eduarda |
dc.subject.por.fl_str_mv |
Rare earth elements Mytilus galloprovincialis Bioaccumulation Metabolisms Oxidative stress Neurotoxicity |
topic |
Rare earth elements Mytilus galloprovincialis Bioaccumulation Metabolisms Oxidative stress Neurotoxicity |
description |
Recently, anthropogenic enrichment of rare earth elements (REE) have been reported in natural environments, due to increasing use and discharges of hospital/industrial wastewaters. Gadolinium (Gd), which is mainly used as contrast agent for magnetic resonance imaging in medical exams, may reach concentrations in water up to two orders of magnitude larger than baseline levels. Nevertheless, in marine systems scarce information is available concerning the toxicity of REE towards inhabiting organisms. This study aimed to evaluate the biochemical impact of anthropogenic Gd in the Mediterranean mussel Mytilus galloprovincialis, which is a species of commercial interest and one of the most accepted pollution bioindicator. Organisms were exposed to different concentrations of Gd (0, 15, 30, 60, 120 µg/L) for 28 days. At the end of the experiments, biomarkers related to mussels’ metabolic (electron transport system activity and energy reserves content), oxidative stress status (cellular damage and the activity of antioxidant and biotransformation enzymes) and neurotoxic effects (activity of the enzyme Acetylcholinesterase) were measured, as well as Gd bioconcentration in organisms. Results showed a high content of Gd (2.5±0.50 µg/g) in mussels exposed to the highest concentration, contrary to those at control condition and at 15 and 30 μg/L of Gd (levels below 0.38 µg/g). Although no mortality was observed during the experimental period, exposure to Gd strongly affected the biochemical performance of M. galloprovincialis, including the decrease on mussels’ metabolism, induction of oxidative stress and neurotoxicity, particularly evidenced at intermediate concentrations. These results may indicate that up to certain stressful levels, although lowering their metabolism, organisms may be able to activate defense strategies to avoid cellular injuries which, on the other hand, may compromise mussels physiological performance such as growth and reproduction success. Nevertheless, our findings support that the widespread utilization of Gd may represent an environmental risk in the future. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05-10T00:00:00Z 2019-05-10 2020-05-11T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/27425 |
url |
http://hdl.handle.net/10773/27425 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0048-9697 https://doi.org/10.1016/j.scitotenv.2019.01.341 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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