Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention?
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/5413 |
Resumo: | Common sage (Salvia officinalis L) is among the plants that are claimed to be beneficial to diabetic patients, and previous studies have suggested that some of its extracts have hypoglycaemic effects in normal and diabetic animals. In this study we purposed to verify the antidiabetic effects of the most common form of consumption of this plant as an infusion (tea). Replacing water with sage tea for 14 days lowered fasting plasma glucose in normal mice but had no effect on glucose clearance in response to an intraperitoneal glucose tolerance test. This indicated effects at level of the liver on gluconeogenesis. Hepatocyte primary cultures of healthy sage tea drinking rats showed, after stimulation, high glucose uptake capacity and a decreased gluconeogenesis in response to glucagon. Sage essential oil further increased hepatocyte sensitivity to insulin and inhibited gluconeogenesis. Overall these effects resemble those of the pharmaceutical drug metformin, a known inhibitor of gluconeogenesis used in the treatment and prevention of type 2 diabetes mellitus. In primary cultures of rat hepatocytes isolated from streptozotocin-induced diabetic rats none of these activities were observed. These results seem to indicate that sage tea does not possess antidiabetic effects at this level. However, its effects on fasting glucose levels in normal animals and the metformin-like effects on rat hepatocytes suggest that sage may be useful as food supplement in the prevention of type 2 diabetes mellitus by lowering plasma glucose of individuals at risk. |
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Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention?Salvia officinalis L.DiabetesMetforminRat hepatocyteHypoglycaemic effectsDiabetes: MetforminScience & TechnologyCommon sage (Salvia officinalis L) is among the plants that are claimed to be beneficial to diabetic patients, and previous studies have suggested that some of its extracts have hypoglycaemic effects in normal and diabetic animals. In this study we purposed to verify the antidiabetic effects of the most common form of consumption of this plant as an infusion (tea). Replacing water with sage tea for 14 days lowered fasting plasma glucose in normal mice but had no effect on glucose clearance in response to an intraperitoneal glucose tolerance test. This indicated effects at level of the liver on gluconeogenesis. Hepatocyte primary cultures of healthy sage tea drinking rats showed, after stimulation, high glucose uptake capacity and a decreased gluconeogenesis in response to glucagon. Sage essential oil further increased hepatocyte sensitivity to insulin and inhibited gluconeogenesis. Overall these effects resemble those of the pharmaceutical drug metformin, a known inhibitor of gluconeogenesis used in the treatment and prevention of type 2 diabetes mellitus. In primary cultures of rat hepatocytes isolated from streptozotocin-induced diabetic rats none of these activities were observed. These results seem to indicate that sage tea does not possess antidiabetic effects at this level. However, its effects on fasting glucose levels in normal animals and the metformin-like effects on rat hepatocytes suggest that sage may be useful as food supplement in the prevention of type 2 diabetes mellitus by lowering plasma glucose of individuals at risk.Fundação para a Ciência e Tecnologia - FCT SFRH/BD/6942/2001; SFRH/BD/12527/2003; POCTI/AGR/62040/2004.Cambridge University PressUniversidade do MinhoLima, Cristóvão F.Azevedo, MarisaAraújo, RitaFerreira, Manuel FernandesWilson, Cristina Pereira2006-082006-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/5413eng"British journal of nutrition". ISSN 1475-2662. 96:2 (Aug. 2006) 326-333.1475-266210.1079/BJN2006183216923227http://caliban.ingentaconnect.com/vl=3577509/cl= 14/nw=1/rpsv/cgi-bin/linker?ini=cabi&reqidx= /ij/cabi/00071145/v96n2/s15/p326info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:03:09Zoai:repositorium.sdum.uminho.pt:1822/5413Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:53:14.190877Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention? |
title |
Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention? |
spellingShingle |
Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention? Lima, Cristóvão F. Salvia officinalis L. Diabetes Metformin Rat hepatocyte Hypoglycaemic effects Diabetes: Metformin Science & Technology |
title_short |
Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention? |
title_full |
Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention? |
title_fullStr |
Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention? |
title_full_unstemmed |
Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention? |
title_sort |
Metformin-like effect of salvia officinalis (common sage) : is it useful in diabetes prevention? |
author |
Lima, Cristóvão F. |
author_facet |
Lima, Cristóvão F. Azevedo, Marisa Araújo, Rita Ferreira, Manuel Fernandes Wilson, Cristina Pereira |
author_role |
author |
author2 |
Azevedo, Marisa Araújo, Rita Ferreira, Manuel Fernandes Wilson, Cristina Pereira |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Lima, Cristóvão F. Azevedo, Marisa Araújo, Rita Ferreira, Manuel Fernandes Wilson, Cristina Pereira |
dc.subject.por.fl_str_mv |
Salvia officinalis L. Diabetes Metformin Rat hepatocyte Hypoglycaemic effects Diabetes: Metformin Science & Technology |
topic |
Salvia officinalis L. Diabetes Metformin Rat hepatocyte Hypoglycaemic effects Diabetes: Metformin Science & Technology |
description |
Common sage (Salvia officinalis L) is among the plants that are claimed to be beneficial to diabetic patients, and previous studies have suggested that some of its extracts have hypoglycaemic effects in normal and diabetic animals. In this study we purposed to verify the antidiabetic effects of the most common form of consumption of this plant as an infusion (tea). Replacing water with sage tea for 14 days lowered fasting plasma glucose in normal mice but had no effect on glucose clearance in response to an intraperitoneal glucose tolerance test. This indicated effects at level of the liver on gluconeogenesis. Hepatocyte primary cultures of healthy sage tea drinking rats showed, after stimulation, high glucose uptake capacity and a decreased gluconeogenesis in response to glucagon. Sage essential oil further increased hepatocyte sensitivity to insulin and inhibited gluconeogenesis. Overall these effects resemble those of the pharmaceutical drug metformin, a known inhibitor of gluconeogenesis used in the treatment and prevention of type 2 diabetes mellitus. In primary cultures of rat hepatocytes isolated from streptozotocin-induced diabetic rats none of these activities were observed. These results seem to indicate that sage tea does not possess antidiabetic effects at this level. However, its effects on fasting glucose levels in normal animals and the metformin-like effects on rat hepatocytes suggest that sage may be useful as food supplement in the prevention of type 2 diabetes mellitus by lowering plasma glucose of individuals at risk. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-08 2006-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/5413 |
url |
http://hdl.handle.net/1822/5413 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"British journal of nutrition". ISSN 1475-2662. 96:2 (Aug. 2006) 326-333. 1475-2662 10.1079/BJN20061832 16923227 http://caliban.ingentaconnect.com/vl=3577509/cl= 14/nw=1/rpsv/cgi-bin/linker?ini=cabi&reqidx= /ij/cabi/00071145/v96n2/s15/p326 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Cambridge University Press |
publisher.none.fl_str_mv |
Cambridge University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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