Cognitive reserve and the severity of Alzheimer’s disease
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10071/9362 |
Resumo: | Alzheimer's disease (AD) is a clinical syndrome caused by neurodegeneration and characterized by a progressive deterioration in cognitive ability and capacity for independent living. Cognitive reserve (CR) describes the capacity of the adult brain to cope with the effects of the neurodegenerative process and to minimize the clinical manifestation of pathology of dementia. The aim of this study was to evaluate the association of CR and the severity of AD. Method: This study was cross-sectional. Functional and neuropsychological abilities of 75 outpatients with probable AD diagnosis were evaluated. Patients completed two questionnaires, "Participation in leisure activities throughout life" and CR Questionnaire. Result: The relationship between Clinical Dementia Rating (CDR) and the level of CR was statistically significant (likelihood ratio (LR), p = 0.015). Conclusion: The level of CR influenced the severity of dementia. This study suggests that AD patients with higher CR may benefit against cognitive decline after diagnosis of AD. |
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Cognitive reserve and the severity of Alzheimer’s diseaseAlzheimer's diseaseCognitive reserveEducationLeisure activitiesLifelong occupationAlzheimer's disease (AD) is a clinical syndrome caused by neurodegeneration and characterized by a progressive deterioration in cognitive ability and capacity for independent living. Cognitive reserve (CR) describes the capacity of the adult brain to cope with the effects of the neurodegenerative process and to minimize the clinical manifestation of pathology of dementia. The aim of this study was to evaluate the association of CR and the severity of AD. Method: This study was cross-sectional. Functional and neuropsychological abilities of 75 outpatients with probable AD diagnosis were evaluated. Patients completed two questionnaires, "Participation in leisure activities throughout life" and CR Questionnaire. Result: The relationship between Clinical Dementia Rating (CDR) and the level of CR was statistically significant (likelihood ratio (LR), p = 0.015). Conclusion: The level of CR influenced the severity of dementia. This study suggests that AD patients with higher CR may benefit against cognitive decline after diagnosis of AD.Academia Brasileira de Neurologia2015-07-20T15:16:20Z2015-01-01T00:00:00Z20152019-05-06T10:51:31Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10071/9362eng0004-282X10.1590/0004-282X20150044Sobral, M.Pestana, M. H.Paúl, C.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-09T17:43:59Zoai:repositorio.iscte-iul.pt:10071/9362Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:20:48.992228Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cognitive reserve and the severity of Alzheimer’s disease |
title |
Cognitive reserve and the severity of Alzheimer’s disease |
spellingShingle |
Cognitive reserve and the severity of Alzheimer’s disease Sobral, M. Alzheimer's disease Cognitive reserve Education Leisure activities Lifelong occupation |
title_short |
Cognitive reserve and the severity of Alzheimer’s disease |
title_full |
Cognitive reserve and the severity of Alzheimer’s disease |
title_fullStr |
Cognitive reserve and the severity of Alzheimer’s disease |
title_full_unstemmed |
Cognitive reserve and the severity of Alzheimer’s disease |
title_sort |
Cognitive reserve and the severity of Alzheimer’s disease |
author |
Sobral, M. |
author_facet |
Sobral, M. Pestana, M. H. Paúl, C. |
author_role |
author |
author2 |
Pestana, M. H. Paúl, C. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Sobral, M. Pestana, M. H. Paúl, C. |
dc.subject.por.fl_str_mv |
Alzheimer's disease Cognitive reserve Education Leisure activities Lifelong occupation |
topic |
Alzheimer's disease Cognitive reserve Education Leisure activities Lifelong occupation |
description |
Alzheimer's disease (AD) is a clinical syndrome caused by neurodegeneration and characterized by a progressive deterioration in cognitive ability and capacity for independent living. Cognitive reserve (CR) describes the capacity of the adult brain to cope with the effects of the neurodegenerative process and to minimize the clinical manifestation of pathology of dementia. The aim of this study was to evaluate the association of CR and the severity of AD. Method: This study was cross-sectional. Functional and neuropsychological abilities of 75 outpatients with probable AD diagnosis were evaluated. Patients completed two questionnaires, "Participation in leisure activities throughout life" and CR Questionnaire. Result: The relationship between Clinical Dementia Rating (CDR) and the level of CR was statistically significant (likelihood ratio (LR), p = 0.015). Conclusion: The level of CR influenced the severity of dementia. This study suggests that AD patients with higher CR may benefit against cognitive decline after diagnosis of AD. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-20T15:16:20Z 2015-01-01T00:00:00Z 2015 2019-05-06T10:51:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10071/9362 |
url |
http://hdl.handle.net/10071/9362 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0004-282X 10.1590/0004-282X20150044 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134768033431552 |