High serum bicarbonate and adverse outcomes in hemodialysis Patients

Detalhes bibliográficos
Autor(a) principal: Ávila,Gonçalo
Data de Publicação: 2021
Outros Autores: Laranjinha,Ivo, Matias,Patrícia
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100035
Resumo: ABSTRACT Metabolic acidosis is a usual complication of progressive chronic kidney disease and is associated with morbidity and mortality. The correction of metabolic acidosis is a main goal of dialysis. In prevalent hemodialysis patients, acid-base homeostasis depends on many factors, mainly net acid production, amount of alkali given by the dialysate bath and duration of the interdialytic period. At present, the main concern in prevalent hemodialysis patients is not over patients with metabolic acidosis, but rather about the growing numbers of patients with metabolic alkalosis. Several large cohort studies have shown significant associations between high predialysis bicarbonate, as well as blood pH, and morbidity and mortality risk. Based on recent guidelines, we should keep predialysis serum bicarbonate concentrations at 24-26 mEq/L, although this is opinion-based and there is no consensus on the issue. Furthermore, there should be specific focus on the patient´s nutritional status and reversible comorbidities.
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spelling High serum bicarbonate and adverse outcomes in hemodialysis Patientsbicarbonatehemodialysismetabolic alkalosismortalityABSTRACT Metabolic acidosis is a usual complication of progressive chronic kidney disease and is associated with morbidity and mortality. The correction of metabolic acidosis is a main goal of dialysis. In prevalent hemodialysis patients, acid-base homeostasis depends on many factors, mainly net acid production, amount of alkali given by the dialysate bath and duration of the interdialytic period. At present, the main concern in prevalent hemodialysis patients is not over patients with metabolic acidosis, but rather about the growing numbers of patients with metabolic alkalosis. Several large cohort studies have shown significant associations between high predialysis bicarbonate, as well as blood pH, and morbidity and mortality risk. Based on recent guidelines, we should keep predialysis serum bicarbonate concentrations at 24-26 mEq/L, although this is opinion-based and there is no consensus on the issue. Furthermore, there should be specific focus on the patient´s nutritional status and reversible comorbidities.Sociedade Portuguesa de Nefrologia2021-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100035Portuguese Journal of Nephrology & Hypertension v.35 n.1 2021reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100035Ávila,GonçaloLaranjinha,IvoMatias,Patríciainfo:eu-repo/semantics/openAccess2024-02-06T17:05:09Zoai:scielo:S0872-01692021000100035Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:05.370424Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv High serum bicarbonate and adverse outcomes in hemodialysis Patients
title High serum bicarbonate and adverse outcomes in hemodialysis Patients
spellingShingle High serum bicarbonate and adverse outcomes in hemodialysis Patients
Ávila,Gonçalo
bicarbonate
hemodialysis
metabolic alkalosis
mortality
title_short High serum bicarbonate and adverse outcomes in hemodialysis Patients
title_full High serum bicarbonate and adverse outcomes in hemodialysis Patients
title_fullStr High serum bicarbonate and adverse outcomes in hemodialysis Patients
title_full_unstemmed High serum bicarbonate and adverse outcomes in hemodialysis Patients
title_sort High serum bicarbonate and adverse outcomes in hemodialysis Patients
author Ávila,Gonçalo
author_facet Ávila,Gonçalo
Laranjinha,Ivo
Matias,Patrícia
author_role author
author2 Laranjinha,Ivo
Matias,Patrícia
author2_role author
author
dc.contributor.author.fl_str_mv Ávila,Gonçalo
Laranjinha,Ivo
Matias,Patrícia
dc.subject.por.fl_str_mv bicarbonate
hemodialysis
metabolic alkalosis
mortality
topic bicarbonate
hemodialysis
metabolic alkalosis
mortality
description ABSTRACT Metabolic acidosis is a usual complication of progressive chronic kidney disease and is associated with morbidity and mortality. The correction of metabolic acidosis is a main goal of dialysis. In prevalent hemodialysis patients, acid-base homeostasis depends on many factors, mainly net acid production, amount of alkali given by the dialysate bath and duration of the interdialytic period. At present, the main concern in prevalent hemodialysis patients is not over patients with metabolic acidosis, but rather about the growing numbers of patients with metabolic alkalosis. Several large cohort studies have shown significant associations between high predialysis bicarbonate, as well as blood pH, and morbidity and mortality risk. Based on recent guidelines, we should keep predialysis serum bicarbonate concentrations at 24-26 mEq/L, although this is opinion-based and there is no consensus on the issue. Furthermore, there should be specific focus on the patient´s nutritional status and reversible comorbidities.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-01
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.35 n.1 2021
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
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