Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://ojs.pjp.spp.pt/article/view/20006 |
Resumo: | Introduction: Therapeutic hypothermia (TH) is the standard of care treatment for brain injury following perinatal hypoxia-ischemia in term infants. Accumulated evidence from clinical trials, systematic reviews and continuous experience shows a reduction in both mortality and long-term neurodevelopmental disability. The aim of our study was to: (i) present the 10-year experience of the neonatal intensive care unit (NICU) that pioneered hypothermia program in Portugal; (ii) evaluate the use of neurologic monitoring and (iii) describe outcomes and adverse events. Methods: Prospective observational study of neonates who underwent TH between November 2009 and October 2019 in a single tertiary level NICU. Results: 128 newborns were treated. 91% were outborn. The median gestational age was 39 weeks. 91% neonates needed advanced resuscitation, and 22% prolonged resuscitation (>10 minutes). On admission, 60% had severe, 26% had moderate and 14% had mild encephalopathy. Hypotension was the most common complication, affecting 66% of the newborns. 21 (16%) patients died during hospital stay. Expected outcome based on aEEG and MRI was favorable in 40%, intermediate in 32% and adverse in 28%. Discussion: Effectiveness and safety profile of TH was confirmed in our population. A national register would be important to achieve and maintain high homogenous and national wide standards of care. |
id |
RCAP_e5ee04b8a16b5964ff56801eace5c2aa |
---|---|
oai_identifier_str |
oai:ojs.revistas.rcaap.pt:article/20006 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year ExperienceHipotermia induzida na encefalopatia hipóxico-isquémicaOriginal articlesIntroduction: Therapeutic hypothermia (TH) is the standard of care treatment for brain injury following perinatal hypoxia-ischemia in term infants. Accumulated evidence from clinical trials, systematic reviews and continuous experience shows a reduction in both mortality and long-term neurodevelopmental disability. The aim of our study was to: (i) present the 10-year experience of the neonatal intensive care unit (NICU) that pioneered hypothermia program in Portugal; (ii) evaluate the use of neurologic monitoring and (iii) describe outcomes and adverse events. Methods: Prospective observational study of neonates who underwent TH between November 2009 and October 2019 in a single tertiary level NICU. Results: 128 newborns were treated. 91% were outborn. The median gestational age was 39 weeks. 91% neonates needed advanced resuscitation, and 22% prolonged resuscitation (>10 minutes). On admission, 60% had severe, 26% had moderate and 14% had mild encephalopathy. Hypotension was the most common complication, affecting 66% of the newborns. 21 (16%) patients died during hospital stay. Expected outcome based on aEEG and MRI was favorable in 40%, intermediate in 32% and adverse in 28%. Discussion: Effectiveness and safety profile of TH was confirmed in our population. A national register would be important to achieve and maintain high homogenous and national wide standards of care.Sociedade Portuguesa de Pediatria2021-02-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://ojs.pjp.spp.pt/article/view/20006eng2184-44532184-3333Sequeira, Ana TeresaGil, JoanaSampaio, IsabelMoniz, CarlosM. Graça, Andreinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T02:58:08Zoai:ojs.revistas.rcaap.pt:article/20006Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:25:34.691103Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience Hipotermia induzida na encefalopatia hipóxico-isquémica |
title |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience |
spellingShingle |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience Sequeira, Ana Teresa Original articles |
title_short |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience |
title_full |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience |
title_fullStr |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience |
title_full_unstemmed |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience |
title_sort |
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: 10-Year Experience |
author |
Sequeira, Ana Teresa |
author_facet |
Sequeira, Ana Teresa Gil, Joana Sampaio, Isabel Moniz, Carlos M. Graça, Andre |
author_role |
author |
author2 |
Gil, Joana Sampaio, Isabel Moniz, Carlos M. Graça, Andre |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sequeira, Ana Teresa Gil, Joana Sampaio, Isabel Moniz, Carlos M. Graça, Andre |
dc.subject.por.fl_str_mv |
Original articles |
topic |
Original articles |
description |
Introduction: Therapeutic hypothermia (TH) is the standard of care treatment for brain injury following perinatal hypoxia-ischemia in term infants. Accumulated evidence from clinical trials, systematic reviews and continuous experience shows a reduction in both mortality and long-term neurodevelopmental disability. The aim of our study was to: (i) present the 10-year experience of the neonatal intensive care unit (NICU) that pioneered hypothermia program in Portugal; (ii) evaluate the use of neurologic monitoring and (iii) describe outcomes and adverse events. Methods: Prospective observational study of neonates who underwent TH between November 2009 and October 2019 in a single tertiary level NICU. Results: 128 newborns were treated. 91% were outborn. The median gestational age was 39 weeks. 91% neonates needed advanced resuscitation, and 22% prolonged resuscitation (>10 minutes). On admission, 60% had severe, 26% had moderate and 14% had mild encephalopathy. Hypotension was the most common complication, affecting 66% of the newborns. 21 (16%) patients died during hospital stay. Expected outcome based on aEEG and MRI was favorable in 40%, intermediate in 32% and adverse in 28%. Discussion: Effectiveness and safety profile of TH was confirmed in our population. A national register would be important to achieve and maintain high homogenous and national wide standards of care. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.pjp.spp.pt/article/view/20006 |
url |
https://ojs.pjp.spp.pt/article/view/20006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2184-4453 2184-3333 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Pediatria |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Pediatria |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133524831240192 |