An antisense transcript mediates MALAT1 response in human breast cancer

Detalhes bibliográficos
Autor(a) principal: Gomes, Carla Pereira
Data de Publicação: 2019
Outros Autores: Nobrega-Pereira, Sandrina, Domingues Silva, Ana Beatriz, Rebelo, Kenny, Alves-Vale, Catarina, Marinho, Sérgio, Carvalho, Tânia, Dias, Sérgio, Jesus, Bruno Bernardes De
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/52592
Resumo: © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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spelling An antisense transcript mediates MALAT1 response in human breast cancerBreast cancerMALAT1MigrationTALAM1lncRNAs© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical applications during aging and disease. As example, targeting of MALAT1, a highly conserved lncRNA originally identified in metastatic non-small cell lung cancer, has shown promising results in cancer regression. Nevertheless, the regulation and specificity of MALAT1 have not been directly addressed. Interestingly, MALAT1 locus is spanned by an antisense transcript named TALAM1. Methods: Here using a collection of breast cancer cells and in vitro and in vivo migration assays we characterized the dynamics of expression and demonstrated that TALAM1 regulates and synergizes with MALAT1 during tumorigenesis. Results: Down-regulation of TALAM1 was shown to greatly impact on the capacity of breast cancer cells to migrate in vitro or to populate the lungs of immunocompromised mice. Additionally, we demonstrated that TALAM1 cooperates with MALAT1 in the regulation of the properties guiding breast cancer aggressiveness and malignancy. Conclusions: By characterizing this sense/anti-sense pair we uncovered the complexity of MALAT1 locus regulation, describing new potential candidates for cancer targeting.This work was supported by Fundação para a Ciência e Tecnologia (FCT) (PTDC/BIM-MED/0032/2014); UID/BIM/50005/2019, project funded by Fundação para a Ciência e a Tecnologia (FCT)/ Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado; LISBOA-01-0145-FEDER-016394, projeto cofinanciado pelo FEDER através POR Lisboa 2020 - Programa Operacional Regional de Lisboa, do PORTUGAL 2020 e pela Fundação para a Ciência e a Tecnologia; LISBOA-01-0145-FEDER-028534, projeto cofinanciado pelo FEDER através POR Lisboa 2020 - Programa Operacional Regional de Lisboa, do PORTUGAL 2020 e pela Fundação para a Ciência e a Tecnologia. B.B.J. was an FCT Investigator (IF/00166/2014). C.V. was a Gulbenkian Foundation Fellow. S.N.-P. was recipient of an individual FCT postdoctoral fellowship (SFRH/BPD/91159/2012).Springer NatureRepositório da Universidade de LisboaGomes, Carla PereiraNobrega-Pereira, SandrinaDomingues Silva, Ana BeatrizRebelo, KennyAlves-Vale, CatarinaMarinho, SérgioCarvalho, TâniaDias, SérgioJesus, Bruno Bernardes De2022-04-28T16:46:50Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52592engBMC Cancer. 2019 Aug 5;19(1):77110.1186/s12885-019-5962-01471-2407info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:57:53Zoai:repositorio.ul.pt:10451/52592Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:40.220248Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An antisense transcript mediates MALAT1 response in human breast cancer
title An antisense transcript mediates MALAT1 response in human breast cancer
spellingShingle An antisense transcript mediates MALAT1 response in human breast cancer
Gomes, Carla Pereira
Breast cancer
MALAT1
Migration
TALAM1
lncRNAs
title_short An antisense transcript mediates MALAT1 response in human breast cancer
title_full An antisense transcript mediates MALAT1 response in human breast cancer
title_fullStr An antisense transcript mediates MALAT1 response in human breast cancer
title_full_unstemmed An antisense transcript mediates MALAT1 response in human breast cancer
title_sort An antisense transcript mediates MALAT1 response in human breast cancer
author Gomes, Carla Pereira
author_facet Gomes, Carla Pereira
Nobrega-Pereira, Sandrina
Domingues Silva, Ana Beatriz
Rebelo, Kenny
Alves-Vale, Catarina
Marinho, Sérgio
Carvalho, Tânia
Dias, Sérgio
Jesus, Bruno Bernardes De
author_role author
author2 Nobrega-Pereira, Sandrina
Domingues Silva, Ana Beatriz
Rebelo, Kenny
Alves-Vale, Catarina
Marinho, Sérgio
Carvalho, Tânia
Dias, Sérgio
Jesus, Bruno Bernardes De
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gomes, Carla Pereira
Nobrega-Pereira, Sandrina
Domingues Silva, Ana Beatriz
Rebelo, Kenny
Alves-Vale, Catarina
Marinho, Sérgio
Carvalho, Tânia
Dias, Sérgio
Jesus, Bruno Bernardes De
dc.subject.por.fl_str_mv Breast cancer
MALAT1
Migration
TALAM1
lncRNAs
topic Breast cancer
MALAT1
Migration
TALAM1
lncRNAs
description © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2022-04-28T16:46:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/52592
url http://hdl.handle.net/10451/52592
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Cancer. 2019 Aug 5;19(1):771
10.1186/s12885-019-5962-0
1471-2407
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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