Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection

Detalhes bibliográficos
Autor(a) principal: Ayatollahi, SA
Data de Publicação: 2021
Outros Autores: Sharifi-Rad, J, Tsouh Fokou, PV, Mahady, GB, Ansar Rasul Suleria, H, Krishna Kapuganti, S, Gadhave, K, Giri, R, Garg, N, Sharma, R, Ribeiro, D, Rodrigues, CF, Reiner, Ž, Taheri, Y, Martins, N
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/153729
Resumo: The current coronavirus disease (COVID-19) outbreak is a significant threat to human health and the worldwide economy. Coronaviruses cause a variety of diseases, such as pneumonia-like upper respiratory tract illnesses, gastroenteritis, encephalitis, multiple organ failure involving lungs and kidneys which might cause death. Since the pandemic started there have been more than 107 million COVID-19 infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ~2.4 million deaths globally. SARS-CoV-2 is easily transmitted from person-to-person and has spread quickly across all continents. With the continued increase in morbidity and mortality caused by COVID-19, and the damage to the global economy, there is an urgent need for effective prevention and treatment strategies. The advent of safe and effective vaccines has been a significant step forward in the battle against COVID-19, however treatment of the symptoms associated with the disease still requires new anti-viral and anti-inflammatory drug therapies. To this end, scientists have been investigating available natural products that may be effective against SARS-CoV-2, with some products showing promise in fighting several viral infections. Since many natural products are dietary components or are prepared as dietary supplements people tend to consider them safer than synthetic drugs. For example, Traditional Chinese Medicines have been effectively utilized to treat SARS-CoV-2 infected patients with promising results. In this review, we summarize the current knowledge of COVID-19 therapies and the therapeutic potential of medicinal plant extracts and natural compounds for the treatment of several viral infections, with special emphasis on SARS-CoV-2 infection. Realistic strategies that can be employed for the effective use of bioactive compounds for anti-SARS-CoV-2 research are also provided.
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spelling Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus InfectionBioactive compoundsCoronavirusCOVID-19Natural compoundsSARS-CoV-2The current coronavirus disease (COVID-19) outbreak is a significant threat to human health and the worldwide economy. Coronaviruses cause a variety of diseases, such as pneumonia-like upper respiratory tract illnesses, gastroenteritis, encephalitis, multiple organ failure involving lungs and kidneys which might cause death. Since the pandemic started there have been more than 107 million COVID-19 infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ~2.4 million deaths globally. SARS-CoV-2 is easily transmitted from person-to-person and has spread quickly across all continents. With the continued increase in morbidity and mortality caused by COVID-19, and the damage to the global economy, there is an urgent need for effective prevention and treatment strategies. The advent of safe and effective vaccines has been a significant step forward in the battle against COVID-19, however treatment of the symptoms associated with the disease still requires new anti-viral and anti-inflammatory drug therapies. To this end, scientists have been investigating available natural products that may be effective against SARS-CoV-2, with some products showing promise in fighting several viral infections. Since many natural products are dietary components or are prepared as dietary supplements people tend to consider them safer than synthetic drugs. For example, Traditional Chinese Medicines have been effectively utilized to treat SARS-CoV-2 infected patients with promising results. In this review, we summarize the current knowledge of COVID-19 therapies and the therapeutic potential of medicinal plant extracts and natural compounds for the treatment of several viral infections, with special emphasis on SARS-CoV-2 infection. Realistic strategies that can be employed for the effective use of bioactive compounds for anti-SARS-CoV-2 research are also provided.Frontiers Media20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/153729eng1663-981210.3389/fphar.2021.575877Ayatollahi, SASharifi-Rad, JTsouh Fokou, PVMahady, GBAnsar Rasul Suleria, HKrishna Kapuganti, SGadhave, KGiri, RGarg, NSharma, RRibeiro, DRodrigues, CFReiner, ŽTaheri, YMartins, Ninfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:27:21Zoai:repositorio-aberto.up.pt:10216/153729Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:01:37.559381Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
title Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
spellingShingle Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
Ayatollahi, SA
Bioactive compounds
Coronavirus
COVID-19
Natural compounds
SARS-CoV-2
title_short Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
title_full Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
title_fullStr Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
title_full_unstemmed Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
title_sort Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
author Ayatollahi, SA
author_facet Ayatollahi, SA
Sharifi-Rad, J
Tsouh Fokou, PV
Mahady, GB
Ansar Rasul Suleria, H
Krishna Kapuganti, S
Gadhave, K
Giri, R
Garg, N
Sharma, R
Ribeiro, D
Rodrigues, CF
Reiner, Ž
Taheri, Y
Martins, N
author_role author
author2 Sharifi-Rad, J
Tsouh Fokou, PV
Mahady, GB
Ansar Rasul Suleria, H
Krishna Kapuganti, S
Gadhave, K
Giri, R
Garg, N
Sharma, R
Ribeiro, D
Rodrigues, CF
Reiner, Ž
Taheri, Y
Martins, N
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ayatollahi, SA
Sharifi-Rad, J
Tsouh Fokou, PV
Mahady, GB
Ansar Rasul Suleria, H
Krishna Kapuganti, S
Gadhave, K
Giri, R
Garg, N
Sharma, R
Ribeiro, D
Rodrigues, CF
Reiner, Ž
Taheri, Y
Martins, N
dc.subject.por.fl_str_mv Bioactive compounds
Coronavirus
COVID-19
Natural compounds
SARS-CoV-2
topic Bioactive compounds
Coronavirus
COVID-19
Natural compounds
SARS-CoV-2
description The current coronavirus disease (COVID-19) outbreak is a significant threat to human health and the worldwide economy. Coronaviruses cause a variety of diseases, such as pneumonia-like upper respiratory tract illnesses, gastroenteritis, encephalitis, multiple organ failure involving lungs and kidneys which might cause death. Since the pandemic started there have been more than 107 million COVID-19 infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ~2.4 million deaths globally. SARS-CoV-2 is easily transmitted from person-to-person and has spread quickly across all continents. With the continued increase in morbidity and mortality caused by COVID-19, and the damage to the global economy, there is an urgent need for effective prevention and treatment strategies. The advent of safe and effective vaccines has been a significant step forward in the battle against COVID-19, however treatment of the symptoms associated with the disease still requires new anti-viral and anti-inflammatory drug therapies. To this end, scientists have been investigating available natural products that may be effective against SARS-CoV-2, with some products showing promise in fighting several viral infections. Since many natural products are dietary components or are prepared as dietary supplements people tend to consider them safer than synthetic drugs. For example, Traditional Chinese Medicines have been effectively utilized to treat SARS-CoV-2 infected patients with promising results. In this review, we summarize the current knowledge of COVID-19 therapies and the therapeutic potential of medicinal plant extracts and natural compounds for the treatment of several viral infections, with special emphasis on SARS-CoV-2 infection. Realistic strategies that can be employed for the effective use of bioactive compounds for anti-SARS-CoV-2 research are also provided.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/153729
url https://hdl.handle.net/10216/153729
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1663-9812
10.3389/fphar.2021.575877
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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