Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents

Detalhes bibliográficos
Autor(a) principal: Marques Gomes, Pedro
Data de Publicação: 2023
Outros Autores: Cabral, Diogo Cunha, Carção, André, Barreto, Joana, Gonçalves, Ana Isabel, Azevedo, Paula, Penêda, José, Duarte, Delfim, Viana, Miguel
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.34631/sporl.2038
Resumo: Introduction: Chronic rhinosinusitis with nasal polyposis is a common pathology in Otorhinolaryngology, and the therapeutic options, in a simplified way, are medical and/or surgical. Medical therapeutic options, in addition to topical and oral corticosteroid therapy, include the use of biological agents. Three biological agents were recently approved for the treatment of chronic rhinosinusitis with nasal polyposis in Portugal, being indicated in critically ill patients not controlled with topical nasal corticosteroid therapy, for whom surgery (unless contraindicated) and/or systemic corticosteroid therapy did not provide adequate control of the disease. Objectives: To propose a clinical evaluation protocol in patients under biological treatment. Methods: Review of relevant medical literature, namely the two main international working groups on this topic: European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS) and European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA). Results: The protocol created can be divided into 3 phases: an initial phase with collection of demographic and clinical data, a second phase with evaluation of eligibility for biologicals based on well-defined admission criteria and a third phase with a proposal of follow-up and application of efficacy and discontinuation criteria. Conclusion: This clinical protocol presents a proposition for the collection of standardized data to be used in clinical practice, which allows a uniform collection for carrying out prospective and/or retrospective multicenter studies, in addition to a proposition for follow-up and evaluation of the efficacy/failure of the treatment with biological agents, in patients with chronic rhinosinusitis with polyposis.
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spelling Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agentsProtocolo de avaliação clínica na rinossinusite crónica com polipose sob tratamento com agentes biológicosRinossinusite crónica com poliposeAgentes BiológicosProtocolo ClínicoChronic rhinosinusitis with polyposisBiological AgentsClinical ProtocolIntroduction: Chronic rhinosinusitis with nasal polyposis is a common pathology in Otorhinolaryngology, and the therapeutic options, in a simplified way, are medical and/or surgical. Medical therapeutic options, in addition to topical and oral corticosteroid therapy, include the use of biological agents. Three biological agents were recently approved for the treatment of chronic rhinosinusitis with nasal polyposis in Portugal, being indicated in critically ill patients not controlled with topical nasal corticosteroid therapy, for whom surgery (unless contraindicated) and/or systemic corticosteroid therapy did not provide adequate control of the disease. Objectives: To propose a clinical evaluation protocol in patients under biological treatment. Methods: Review of relevant medical literature, namely the two main international working groups on this topic: European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS) and European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA). Results: The protocol created can be divided into 3 phases: an initial phase with collection of demographic and clinical data, a second phase with evaluation of eligibility for biologicals based on well-defined admission criteria and a third phase with a proposal of follow-up and application of efficacy and discontinuation criteria. Conclusion: This clinical protocol presents a proposition for the collection of standardized data to be used in clinical practice, which allows a uniform collection for carrying out prospective and/or retrospective multicenter studies, in addition to a proposition for follow-up and evaluation of the efficacy/failure of the treatment with biological agents, in patients with chronic rhinosinusitis with polyposis.Introdução: A rinossinusite crónica com polipose nasal é uma patologia comum em Otorrinolaringologia, sendo as opções terapêuticas, de uma forma simplificada, médicas e/ou cirúrgicas. As opções terapêuticas médicas, além da corticoterapia tópica e oral, englobam a utilização de agentes biológicos. Foi recentemente aprovada a Autorização de Introdução no Mercado Português de três agentes biológicos para o tratamento da rinossinusite crónica com polipose nasal, estando indicados em doentes graves e não controlados com corticoterapia tópica nasal, para quem a cirurgia (excepto se contraindicada) e/ou corticoterapia sistémica não forneceu controlo adequado da doença. Objetivos: Propor um protocolo avaliação clínica em doentes que se encontram sob tratamento com biológicos. Métodos: Revisão da literatura médica pertinente, nomeadamente dos dois principais grupos   de trabalho internacionais sobre este tema: European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS) e European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA).   Resultados: O protocolo criado pode ser divido em 3 fases: uma fase inicial com colheita de dados demográficos e clínicos, uma segunda fase com avaliação de elegibilidade para biológicos com base em critérios de admissão bem definidos e uma terceira fase com uma proposta de seguimento e aplicação de critérios de eficácia e de suspensão da terapêutica. Conclusão: Este protocolo clínico apresenta uma proposta de colheita de dados padronizados a utilizar na prática clínica, que permita uma colheita uniforme para a realização de estudos multicêntricos prospetivos e/ou retrospetivos, além de uma proposta de seguimento e avaliação da eficácia/insucesso do tratamento com agentes biológicos, em doentes com rinossinusite crónica com polipose.Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2023-08-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.34631/sporl.2038https://doi.org/10.34631/sporl.2038Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 61 No. 2 (2023): June; 157-170Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 61 Núm. 2 (2023): Junho; 157-170Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 61 N.º 2 (2023): Junho; 157-1702184-6499reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPengporhttps://journalsporl.com/index.php/sporl/article/view/2038https://journalsporl.com/index.php/sporl/article/view/2038/35https://journalsporl.com/index.php/sporl/article/view/2038/36Direitos de Autor (c) 2023 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoçoinfo:eu-repo/semantics/openAccessMarques Gomes, PedroCabral, Diogo CunhaCarção, AndréBarreto, JoanaGonçalves, Ana IsabelAzevedo, PaulaPenêda, JoséDuarte, DelfimViana, Miguel2023-11-09T12:00:33Zoai:journalsporl.com:article/2038Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:10:09.034825Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents
Protocolo de avaliação clínica na rinossinusite crónica com polipose sob tratamento com agentes biológicos
title Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents
spellingShingle Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents
Marques Gomes, Pedro
Rinossinusite crónica com polipose
Agentes Biológicos
Protocolo Clínico
Chronic rhinosinusitis with polyposis
Biological Agents
Clinical Protocol
title_short Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents
title_full Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents
title_fullStr Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents
title_full_unstemmed Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents
title_sort Clinical evaluation protocol for chronic rhinosinusitis with polyposis during treatment with biological agents
author Marques Gomes, Pedro
author_facet Marques Gomes, Pedro
Cabral, Diogo Cunha
Carção, André
Barreto, Joana
Gonçalves, Ana Isabel
Azevedo, Paula
Penêda, José
Duarte, Delfim
Viana, Miguel
author_role author
author2 Cabral, Diogo Cunha
Carção, André
Barreto, Joana
Gonçalves, Ana Isabel
Azevedo, Paula
Penêda, José
Duarte, Delfim
Viana, Miguel
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Marques Gomes, Pedro
Cabral, Diogo Cunha
Carção, André
Barreto, Joana
Gonçalves, Ana Isabel
Azevedo, Paula
Penêda, José
Duarte, Delfim
Viana, Miguel
dc.subject.por.fl_str_mv Rinossinusite crónica com polipose
Agentes Biológicos
Protocolo Clínico
Chronic rhinosinusitis with polyposis
Biological Agents
Clinical Protocol
topic Rinossinusite crónica com polipose
Agentes Biológicos
Protocolo Clínico
Chronic rhinosinusitis with polyposis
Biological Agents
Clinical Protocol
description Introduction: Chronic rhinosinusitis with nasal polyposis is a common pathology in Otorhinolaryngology, and the therapeutic options, in a simplified way, are medical and/or surgical. Medical therapeutic options, in addition to topical and oral corticosteroid therapy, include the use of biological agents. Three biological agents were recently approved for the treatment of chronic rhinosinusitis with nasal polyposis in Portugal, being indicated in critically ill patients not controlled with topical nasal corticosteroid therapy, for whom surgery (unless contraindicated) and/or systemic corticosteroid therapy did not provide adequate control of the disease. Objectives: To propose a clinical evaluation protocol in patients under biological treatment. Methods: Review of relevant medical literature, namely the two main international working groups on this topic: European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS) and European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA). Results: The protocol created can be divided into 3 phases: an initial phase with collection of demographic and clinical data, a second phase with evaluation of eligibility for biologicals based on well-defined admission criteria and a third phase with a proposal of follow-up and application of efficacy and discontinuation criteria. Conclusion: This clinical protocol presents a proposition for the collection of standardized data to be used in clinical practice, which allows a uniform collection for carrying out prospective and/or retrospective multicenter studies, in addition to a proposition for follow-up and evaluation of the efficacy/failure of the treatment with biological agents, in patients with chronic rhinosinusitis with polyposis.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-28
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.34631/sporl.2038
https://doi.org/10.34631/sporl.2038
url https://doi.org/10.34631/sporl.2038
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://journalsporl.com/index.php/sporl/article/view/2038
https://journalsporl.com/index.php/sporl/article/view/2038/35
https://journalsporl.com/index.php/sporl/article/view/2038/36
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2023 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2023 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.source.none.fl_str_mv Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 61 No. 2 (2023): June; 157-170
Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 61 Núm. 2 (2023): Junho; 157-170
Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 61 N.º 2 (2023): Junho; 157-170
2184-6499
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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