In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol

Detalhes bibliográficos
Autor(a) principal: Querido, Micaela
Data de Publicação: 2022
Outros Autores: Rosário, Fernanda, Bessa, Maria, Mendes, Francisca, Teixeira, José, Teixeira, João, Pereira, Cristiana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8593
Resumo: This article belongs to the Section Toxicology.
id RCAP_e7b5a03a970fae9e3cd3758f8dedd3e4
oai_identifier_str oai:repositorio.insa.pt:10400.18/8593
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and IsoborneolAntibacterialCytotoxicityGenotoxicityIsoborneolPaintTriclosanGenotoxicidade AmbientalThis article belongs to the Section Toxicology.Surfaces with antimicrobial properties are gaining notoriety as an efficient method to avoid surface contamination. Self-disinfecting paints are a promising strategy towards cleaner indoor environments by preventing the colonization of walls with microorganisms. However, its widespread use needs an appropriate toxicological safety evaluation due to the potential for biological disturbance associated to its biocidal activity. In this work, the cyto- and genotoxic assessment of two self-disinfecting paints containing the antimicrobial substances triclosan (TCS) and isoborneol (ISB) is performed. HaCaT and A549 cell lines models were selected for the in vitro assessment. To evaluate the cytotoxicity, tests by direct contact and on extracts obtained from leaching were performed following ISO 10993, whereas the genotoxicity was assessed by comet assay and cytokinesis-block micronucleus (CBMN) assay. The results showed low levels of cyto- and genotoxicity under the models and conditions tested, indicating that these substances have commercial potential.This research was funded by Programa Operacional Competitividade e Internacionalização— COMPETE2020/FEDER, towards the project B-Safecoat (POCI-01-0247-FEDER-017875), and by FCT (Fundação para a Ciência e Tecnologia) through the PhD grants awarded to M.M.Q. (SFRH/BD/130203/2017) and M.J.B (SFRH/BD/120646/2016).MDPIRepositório Científico do Instituto Nacional de SaúdeQuerido, MicaelaRosário, FernandaBessa, MariaMendes, FranciscaTeixeira, JoséTeixeira, JoãoPereira, Cristiana2023-03-21T15:42:59Z2022-01-272022-01-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8593engToxics. 2022 Jan 27;10(2):58. doi: 10.3390/toxics10020058.2305-630410.3390/toxics10020058info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:39Zoai:repositorio.insa.pt:10400.18/8593Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:14.468316Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
title In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
spellingShingle In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
Querido, Micaela
Antibacterial
Cytotoxicity
Genotoxicity
Isoborneol
Paint
Triclosan
Genotoxicidade Ambiental
title_short In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
title_full In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
title_fullStr In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
title_full_unstemmed In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
title_sort In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
author Querido, Micaela
author_facet Querido, Micaela
Rosário, Fernanda
Bessa, Maria
Mendes, Francisca
Teixeira, José
Teixeira, João
Pereira, Cristiana
author_role author
author2 Rosário, Fernanda
Bessa, Maria
Mendes, Francisca
Teixeira, José
Teixeira, João
Pereira, Cristiana
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Querido, Micaela
Rosário, Fernanda
Bessa, Maria
Mendes, Francisca
Teixeira, José
Teixeira, João
Pereira, Cristiana
dc.subject.por.fl_str_mv Antibacterial
Cytotoxicity
Genotoxicity
Isoborneol
Paint
Triclosan
Genotoxicidade Ambiental
topic Antibacterial
Cytotoxicity
Genotoxicity
Isoborneol
Paint
Triclosan
Genotoxicidade Ambiental
description This article belongs to the Section Toxicology.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-27
2022-01-27T00:00:00Z
2023-03-21T15:42:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8593
url http://hdl.handle.net/10400.18/8593
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxics. 2022 Jan 27;10(2):58. doi: 10.3390/toxics10020058.
2305-6304
10.3390/toxics10020058
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132177671127040

Registros relacionados