Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8950 |
Resumo: | Author affiliations: Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal (I. Kislaya, V. Borges, C. Matias Dias, S. Duarte, L. Coelho, R. Ferreira, J. Isidro, M. Pinto, D. Sobral, A. Nunes, D. Santos, L. Vieira, J.P. Gomes, B. Nunes, A. Machado). |
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Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, PortugalBA.2BA.5COVID-19OmicronSARS-CoV-2Coronavirus DiseaseDeathHospitalizationPostinfection Vaccine EffectivenessRespiratory InfectionsSevere Acute Respiratory Syndrome Coronavirus 2Vaccine-preventable DiseasesVirusesPortugalInfecções RespiratóriasDoenças Evitáveis pela VacinaçãoDeterminantes da Saúde e da DoençaAuthor affiliations: Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal (I. Kislaya, V. Borges, C. Matias Dias, S. Duarte, L. Coelho, R. Ferreira, J. Isidro, M. Pinto, D. Sobral, A. Nunes, D. Santos, L. Vieira, J.P. Gomes, B. Nunes, A. Machado).We estimated comparative primary and booster vaccine effectiveness (VE) of SARS-CoV-2 Omicron BA.5 and BA.2 lineages against infection and disease progression. During April-June 2022, we implemented a case-case and cohort study and classified lineages using whole-genome sequencing or spike gene target failure. For the case-case study, we estimated the adjusted odds ratios (aORs) of vaccination using a logistic regression. For the cohort study, we estimated VE against disease progression using a penalized logistic regression. We observed no reduced VE for primary (aOR 1.07 [95% CI 0.93-1.23]) or booster (aOR 0.96 [95% CI 0.84-1.09]) vaccination against BA.5 infection. Among BA.5 case-patients, booster VE against progression to hospitalization was lower than that among BA.2 case-patients (VE 77% [95% CI 49%-90%] vs. VE 93% [95% CI 86%-97%]). Although booster vaccination is less effective against BA.5 than against BA.2, it offers substantial protection against progression from BA.5 infection to severe disease.The acquisition of sequencing equipment and reagents used in this study by the Instituto Nacional de Saúde Doutor Ricardo Jorge was partially funded by the HERA project (grant no. 2021/PHF/23776) supported by the European Commission through the European Centre for Disease Control, and also partially funded by the GenomePT project (grant no. POCI-01-0145-FEDER-022184), supported by COMPETE 2020–Operational Programme for Competitiveness and Internationalisation, Lisboa Portugal Regional Operational Programme, Algarve Portugal Regional Operational, under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund, and by the Portuguese Science and Technology Foundation. Algarve Biomedical Center Laboratory received public funding through the Project ALG-D2-2021-06 Variants Screen in Southern Portugal– Monitoring Variants of Concern in Southern Portugal and the Portuguese Science and Technology Foundation national support through the Comprehensive Health Research Center (grant no. UIDP/04923/2020)Centers for Disease Control and PreventionRepositório Científico do Instituto Nacional de SaúdeKislaya, IrinaCasaca, PedroBorges, VítorSousa, CarlosFerreira, Bibiana I.Fonte, AnaFernandes, EugéniaDias, Carlos MatiasDuarte, SílviaAlmeida, José PedroGrenho, InêsCoelho, LuísFerreira, RitaFerreira, Patrícia PitaBorges, Cláudia MedeirosIsidro, JoanaPinto, MiguelMenezes, LuísSobral, DanielNunes, AlexandraSantos, DanielaGonçalves, António MaiaVieira, LuísGomes, João PauloLeite, Pedro PintoNunes, BaltazarMachado, AusendaPeralta-Santos, André2024-01-22T16:15:30Z2023-032023-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8950engEmerg Infect Dis. 2023 Mar;29(3):569-575. doi: 10.3201/eid2903.221367. Epub 2023 Feb 31080-604010.3201/eid2903.221367info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-02T01:30:24Zoai:repositorio.insa.pt:10400.18/8950Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:57:59.823111Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal |
| title |
Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal |
| spellingShingle |
Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal Kislaya, Irina BA.2 BA.5 COVID-19 Omicron SARS-CoV-2 Coronavirus Disease Death Hospitalization Postinfection Vaccine Effectiveness Respiratory Infections Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine-preventable Diseases Viruses Portugal Infecções Respiratórias Doenças Evitáveis pela Vacinação Determinantes da Saúde e da Doença |
| title_short |
Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal |
| title_full |
Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal |
| title_fullStr |
Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal |
| title_full_unstemmed |
Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal |
| title_sort |
Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Disease Progression from SARS-CoV-2 Omicron BA.5 and BA.2, Portugal |
| author |
Kislaya, Irina |
| author_facet |
Kislaya, Irina Casaca, Pedro Borges, Vítor Sousa, Carlos Ferreira, Bibiana I. Fonte, Ana Fernandes, Eugénia Dias, Carlos Matias Duarte, Sílvia Almeida, José Pedro Grenho, Inês Coelho, Luís Ferreira, Rita Ferreira, Patrícia Pita Borges, Cláudia Medeiros Isidro, Joana Pinto, Miguel Menezes, Luís Sobral, Daniel Nunes, Alexandra Santos, Daniela Gonçalves, António Maia Vieira, Luís Gomes, João Paulo Leite, Pedro Pinto Nunes, Baltazar Machado, Ausenda Peralta-Santos, André |
| author_role |
author |
| author2 |
Casaca, Pedro Borges, Vítor Sousa, Carlos Ferreira, Bibiana I. Fonte, Ana Fernandes, Eugénia Dias, Carlos Matias Duarte, Sílvia Almeida, José Pedro Grenho, Inês Coelho, Luís Ferreira, Rita Ferreira, Patrícia Pita Borges, Cláudia Medeiros Isidro, Joana Pinto, Miguel Menezes, Luís Sobral, Daniel Nunes, Alexandra Santos, Daniela Gonçalves, António Maia Vieira, Luís Gomes, João Paulo Leite, Pedro Pinto Nunes, Baltazar Machado, Ausenda Peralta-Santos, André |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Kislaya, Irina Casaca, Pedro Borges, Vítor Sousa, Carlos Ferreira, Bibiana I. Fonte, Ana Fernandes, Eugénia Dias, Carlos Matias Duarte, Sílvia Almeida, José Pedro Grenho, Inês Coelho, Luís Ferreira, Rita Ferreira, Patrícia Pita Borges, Cláudia Medeiros Isidro, Joana Pinto, Miguel Menezes, Luís Sobral, Daniel Nunes, Alexandra Santos, Daniela Gonçalves, António Maia Vieira, Luís Gomes, João Paulo Leite, Pedro Pinto Nunes, Baltazar Machado, Ausenda Peralta-Santos, André |
| dc.subject.por.fl_str_mv |
BA.2 BA.5 COVID-19 Omicron SARS-CoV-2 Coronavirus Disease Death Hospitalization Postinfection Vaccine Effectiveness Respiratory Infections Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine-preventable Diseases Viruses Portugal Infecções Respiratórias Doenças Evitáveis pela Vacinação Determinantes da Saúde e da Doença |
| topic |
BA.2 BA.5 COVID-19 Omicron SARS-CoV-2 Coronavirus Disease Death Hospitalization Postinfection Vaccine Effectiveness Respiratory Infections Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine-preventable Diseases Viruses Portugal Infecções Respiratórias Doenças Evitáveis pela Vacinação Determinantes da Saúde e da Doença |
| description |
Author affiliations: Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal (I. Kislaya, V. Borges, C. Matias Dias, S. Duarte, L. Coelho, R. Ferreira, J. Isidro, M. Pinto, D. Sobral, A. Nunes, D. Santos, L. Vieira, J.P. Gomes, B. Nunes, A. Machado). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-03 2023-03-01T00:00:00Z 2024-01-22T16:15:30Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8950 |
| url |
http://hdl.handle.net/10400.18/8950 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Emerg Infect Dis. 2023 Mar;29(3):569-575. doi: 10.3201/eid2903.221367. Epub 2023 Feb 3 1080-6040 10.3201/eid2903.221367 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Centers for Disease Control and Prevention |
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Centers for Disease Control and Prevention |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137065686794240 |