Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015

Detalhes bibliográficos
Autor(a) principal: Ferreira, Muriel
Data de Publicação: 2017
Outros Autores: Oliveira, Henrique, Silva, Nuno Costa e, Januário, Luís, Rodrigues, Fernanda
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493
Resumo: Introduction: Pneumococcal conjugate vaccine was introduced in the private market in Portugal in 2001, reaching over the years a moderately high coverage. In July 2015, it was included in the National Immunisation Program. The aim of this study was to characterize invasive pneumococcal disease in a pediatric hospital before universal use of the vaccine.Material and Methods: Retrospective analysis of medical records of all children with Streptococcus pneumoniae identified by culture and/or molecular biology (available since 2008), in products obtained from sterile sites, from January 1995 to June 2015. We evaluated demographic, clinical and microbiological data. Serotype results are available since 2004.Results: Over those 20 years, 112 invasive pneumococcal disease cases were identified, with a median age of 15 months (1 month - 15 years). The median number of cases /year was 4, the highest between 2001 - 2002 (8/year) and 2007 - 2012 (7 - 11/year). The identification occurred mostly in blood culture (72), cerebrospinal fluid (24), pleural fluid (11) an others (5). The most frequent diagnoses were pneumonia (38%), occult bacteraemia (34%) and meningitis (21%). Over the period under review, there was an increase of pneumonia and slight increase of OB, with meningitis cases remaining relatively unchanged.Discussion: In the last two decades, there was no reduction in the number of cases of invasive pneumococcal disease. There was an increase in isolates from pneumonia and occult bacteraemia that might be due to the introduction of molecular biological methods for Streptococcus pneumoniae detection. Vaccine serotypes were predominant.Conclusion: This retrospective analysis before universal vaccination will contribute to evaluate the impact of vaccination in the Portuguese pediatric population.
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spelling Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015Doença Invasiva Pneumocócica Pediátrica Antes da Vacinação Universal: 1995 - 2015ChildPneumococcal InfectionsPneumococcal VaccinesPortugalVaccinesConjugateCriançaInfecções PneumocócicasPortugalVacinas ConjugadasVacinas PneumocócicasIntroduction: Pneumococcal conjugate vaccine was introduced in the private market in Portugal in 2001, reaching over the years a moderately high coverage. In July 2015, it was included in the National Immunisation Program. The aim of this study was to characterize invasive pneumococcal disease in a pediatric hospital before universal use of the vaccine.Material and Methods: Retrospective analysis of medical records of all children with Streptococcus pneumoniae identified by culture and/or molecular biology (available since 2008), in products obtained from sterile sites, from January 1995 to June 2015. We evaluated demographic, clinical and microbiological data. Serotype results are available since 2004.Results: Over those 20 years, 112 invasive pneumococcal disease cases were identified, with a median age of 15 months (1 month - 15 years). The median number of cases /year was 4, the highest between 2001 - 2002 (8/year) and 2007 - 2012 (7 - 11/year). The identification occurred mostly in blood culture (72), cerebrospinal fluid (24), pleural fluid (11) an others (5). The most frequent diagnoses were pneumonia (38%), occult bacteraemia (34%) and meningitis (21%). Over the period under review, there was an increase of pneumonia and slight increase of OB, with meningitis cases remaining relatively unchanged.Discussion: In the last two decades, there was no reduction in the number of cases of invasive pneumococcal disease. There was an increase in isolates from pneumonia and occult bacteraemia that might be due to the introduction of molecular biological methods for Streptococcus pneumoniae detection. Vaccine serotypes were predominant.Conclusion: This retrospective analysis before universal vaccination will contribute to evaluate the impact of vaccination in the Portuguese pediatric population.Introdução: A vacina conjugada pneumocócica foi introduzida no mercado privado português em 2001, atingindo ao longo dos anos coberturas moderadamente elevadas. Em julho de 2015 foi integrada no Programa Nacional de Vacinação. O objetivo deste estudo foi caracterizar a doença invasiva pneumocócica num hospital pediátrico antes da vacinação universal.Material e Métodos: Análise retrospetiva dos processos clínicos de todas as crianças com identificação de Streptococcus pneumoniae por cultura e/ou por biologia molecular (disponível desde 2008), em produtos obtidos de locais estéreis, de janeiro 1995 a junho 2015, avaliando dados demográficos, clínicos e microbiológicos. Os serotipos estão disponíveis desde 2004.Resultados: Ao longo destes 20 anos identificámos 112 casos de doença invasiva pneumocócica, com idade mediana de 15 meses (1 mês - 15 anos). A mediana de casos/ano foi 4, com valores máximos entre 2001 - 2002 (8/ano) e 2007 - 2012 (7 - 11/ano). A identificação ocorreu maioritariamente em hemocultura (72), líquido cefalorraquidiano (24), líquido pleural (11) e outros (5). Os diagnósticos mais frequentes foram pneumonia (38%), bacteriemia oculta (34%) e meningite (21%). Ao longo do período em análise, observou-se um aumento do diagnóstico de pneumonia e aumento ligeiro de bacteriemia oculta, tendo-se mantido relativamente constante o de meningite.Discussão: Nas últimas duas décadas não se observou redução do número de casos de doença invasiva pneumocócica, tendo ocorrido um aumento da identificação de pneumococo em pneumonia e bacteriemia oculta, para o qual poderão ter contribuído a introdução dos métodos de biologia molecular e a realização de mais hemoculturas. Os serotipos vacinais foram predominantes.Conclusão: Esta analise retrospetiva pré vacinação universal, contribuirá para avaliar o impacto da vacinação na população pediátrica portuguesa.Ordem dos Médicos2017-06-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfimage/jpegimage/jpegapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentimage/jpeghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493oai:ojs.www.actamedicaportuguesa.com:article/8493Acta Médica Portuguesa; Vol. 30 No. 6 (2017): June; 457-462Acta Médica Portuguesa; Vol. 30 N.º 6 (2017): Junho; 457-4621646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/5074https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/5365https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8911https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8912https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8941https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/9224https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/9315Direitos de Autor (c) 2017 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessFerreira, MurielOliveira, HenriqueSilva, Nuno Costa eJanuário, LuísRodrigues, Fernanda2022-12-20T11:05:32Zoai:ojs.www.actamedicaportuguesa.com:article/8493Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:36.236354Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
Doença Invasiva Pneumocócica Pediátrica Antes da Vacinação Universal: 1995 - 2015
title Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
spellingShingle Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
Ferreira, Muriel
Child
Pneumococcal Infections
Pneumococcal Vaccines
Portugal
Vaccines
Conjugate
Criança
Infecções Pneumocócicas
Portugal
Vacinas Conjugadas
Vacinas Pneumocócicas
title_short Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
title_full Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
title_fullStr Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
title_full_unstemmed Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
title_sort Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
author Ferreira, Muriel
author_facet Ferreira, Muriel
Oliveira, Henrique
Silva, Nuno Costa e
Januário, Luís
Rodrigues, Fernanda
author_role author
author2 Oliveira, Henrique
Silva, Nuno Costa e
Januário, Luís
Rodrigues, Fernanda
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Muriel
Oliveira, Henrique
Silva, Nuno Costa e
Januário, Luís
Rodrigues, Fernanda
dc.subject.por.fl_str_mv Child
Pneumococcal Infections
Pneumococcal Vaccines
Portugal
Vaccines
Conjugate
Criança
Infecções Pneumocócicas
Portugal
Vacinas Conjugadas
Vacinas Pneumocócicas
topic Child
Pneumococcal Infections
Pneumococcal Vaccines
Portugal
Vaccines
Conjugate
Criança
Infecções Pneumocócicas
Portugal
Vacinas Conjugadas
Vacinas Pneumocócicas
description Introduction: Pneumococcal conjugate vaccine was introduced in the private market in Portugal in 2001, reaching over the years a moderately high coverage. In July 2015, it was included in the National Immunisation Program. The aim of this study was to characterize invasive pneumococcal disease in a pediatric hospital before universal use of the vaccine.Material and Methods: Retrospective analysis of medical records of all children with Streptococcus pneumoniae identified by culture and/or molecular biology (available since 2008), in products obtained from sterile sites, from January 1995 to June 2015. We evaluated demographic, clinical and microbiological data. Serotype results are available since 2004.Results: Over those 20 years, 112 invasive pneumococcal disease cases were identified, with a median age of 15 months (1 month - 15 years). The median number of cases /year was 4, the highest between 2001 - 2002 (8/year) and 2007 - 2012 (7 - 11/year). The identification occurred mostly in blood culture (72), cerebrospinal fluid (24), pleural fluid (11) an others (5). The most frequent diagnoses were pneumonia (38%), occult bacteraemia (34%) and meningitis (21%). Over the period under review, there was an increase of pneumonia and slight increase of OB, with meningitis cases remaining relatively unchanged.Discussion: In the last two decades, there was no reduction in the number of cases of invasive pneumococcal disease. There was an increase in isolates from pneumonia and occult bacteraemia that might be due to the introduction of molecular biological methods for Streptococcus pneumoniae detection. Vaccine serotypes were predominant.Conclusion: This retrospective analysis before universal vaccination will contribute to evaluate the impact of vaccination in the Portuguese pediatric population.
publishDate 2017
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/5074
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/5365
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8911
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8912
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/9224
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/9315
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2017 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 30 No. 6 (2017): June; 457-462
Acta Médica Portuguesa; Vol. 30 N.º 6 (2017): Junho; 457-462
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