Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493 |
Resumo: | Introduction: Pneumococcal conjugate vaccine was introduced in the private market in Portugal in 2001, reaching over the years a moderately high coverage. In July 2015, it was included in the National Immunisation Program. The aim of this study was to characterize invasive pneumococcal disease in a pediatric hospital before universal use of the vaccine.Material and Methods: Retrospective analysis of medical records of all children with Streptococcus pneumoniae identified by culture and/or molecular biology (available since 2008), in products obtained from sterile sites, from January 1995 to June 2015. We evaluated demographic, clinical and microbiological data. Serotype results are available since 2004.Results: Over those 20 years, 112 invasive pneumococcal disease cases were identified, with a median age of 15 months (1 month - 15 years). The median number of cases /year was 4, the highest between 2001 - 2002 (8/year) and 2007 - 2012 (7 - 11/year). The identification occurred mostly in blood culture (72), cerebrospinal fluid (24), pleural fluid (11) an others (5). The most frequent diagnoses were pneumonia (38%), occult bacteraemia (34%) and meningitis (21%). Over the period under review, there was an increase of pneumonia and slight increase of OB, with meningitis cases remaining relatively unchanged.Discussion: In the last two decades, there was no reduction in the number of cases of invasive pneumococcal disease. There was an increase in isolates from pneumonia and occult bacteraemia that might be due to the introduction of molecular biological methods for Streptococcus pneumoniae detection. Vaccine serotypes were predominant.Conclusion: This retrospective analysis before universal vaccination will contribute to evaluate the impact of vaccination in the Portuguese pediatric population. |
id |
RCAP_e8e5f6fbd4a431df17c32a2d1aee210b |
---|---|
oai_identifier_str |
oai:ojs.www.actamedicaportuguesa.com:article/8493 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015Doença Invasiva Pneumocócica Pediátrica Antes da Vacinação Universal: 1995 - 2015ChildPneumococcal InfectionsPneumococcal VaccinesPortugalVaccinesConjugateCriançaInfecções PneumocócicasPortugalVacinas ConjugadasVacinas PneumocócicasIntroduction: Pneumococcal conjugate vaccine was introduced in the private market in Portugal in 2001, reaching over the years a moderately high coverage. In July 2015, it was included in the National Immunisation Program. The aim of this study was to characterize invasive pneumococcal disease in a pediatric hospital before universal use of the vaccine.Material and Methods: Retrospective analysis of medical records of all children with Streptococcus pneumoniae identified by culture and/or molecular biology (available since 2008), in products obtained from sterile sites, from January 1995 to June 2015. We evaluated demographic, clinical and microbiological data. Serotype results are available since 2004.Results: Over those 20 years, 112 invasive pneumococcal disease cases were identified, with a median age of 15 months (1 month - 15 years). The median number of cases /year was 4, the highest between 2001 - 2002 (8/year) and 2007 - 2012 (7 - 11/year). The identification occurred mostly in blood culture (72), cerebrospinal fluid (24), pleural fluid (11) an others (5). The most frequent diagnoses were pneumonia (38%), occult bacteraemia (34%) and meningitis (21%). Over the period under review, there was an increase of pneumonia and slight increase of OB, with meningitis cases remaining relatively unchanged.Discussion: In the last two decades, there was no reduction in the number of cases of invasive pneumococcal disease. There was an increase in isolates from pneumonia and occult bacteraemia that might be due to the introduction of molecular biological methods for Streptococcus pneumoniae detection. Vaccine serotypes were predominant.Conclusion: This retrospective analysis before universal vaccination will contribute to evaluate the impact of vaccination in the Portuguese pediatric population.Introdução: A vacina conjugada pneumocócica foi introduzida no mercado privado português em 2001, atingindo ao longo dos anos coberturas moderadamente elevadas. Em julho de 2015 foi integrada no Programa Nacional de Vacinação. O objetivo deste estudo foi caracterizar a doença invasiva pneumocócica num hospital pediátrico antes da vacinação universal.Material e Métodos: Análise retrospetiva dos processos clínicos de todas as crianças com identificação de Streptococcus pneumoniae por cultura e/ou por biologia molecular (disponível desde 2008), em produtos obtidos de locais estéreis, de janeiro 1995 a junho 2015, avaliando dados demográficos, clínicos e microbiológicos. Os serotipos estão disponíveis desde 2004.Resultados: Ao longo destes 20 anos identificámos 112 casos de doença invasiva pneumocócica, com idade mediana de 15 meses (1 mês - 15 anos). A mediana de casos/ano foi 4, com valores máximos entre 2001 - 2002 (8/ano) e 2007 - 2012 (7 - 11/ano). A identificação ocorreu maioritariamente em hemocultura (72), líquido cefalorraquidiano (24), líquido pleural (11) e outros (5). Os diagnósticos mais frequentes foram pneumonia (38%), bacteriemia oculta (34%) e meningite (21%). Ao longo do período em análise, observou-se um aumento do diagnóstico de pneumonia e aumento ligeiro de bacteriemia oculta, tendo-se mantido relativamente constante o de meningite.Discussão: Nas últimas duas décadas não se observou redução do número de casos de doença invasiva pneumocócica, tendo ocorrido um aumento da identificação de pneumococo em pneumonia e bacteriemia oculta, para o qual poderão ter contribuído a introdução dos métodos de biologia molecular e a realização de mais hemoculturas. Os serotipos vacinais foram predominantes.Conclusão: Esta analise retrospetiva pré vacinação universal, contribuirá para avaliar o impacto da vacinação na população pediátrica portuguesa.Ordem dos Médicos2017-06-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfimage/jpegimage/jpegapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentimage/jpeghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493oai:ojs.www.actamedicaportuguesa.com:article/8493Acta Médica Portuguesa; Vol. 30 No. 6 (2017): June; 457-462Acta Médica Portuguesa; Vol. 30 N.º 6 (2017): Junho; 457-4621646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/5074https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/5365https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8911https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8912https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8941https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/9224https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/9315Direitos de Autor (c) 2017 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessFerreira, MurielOliveira, HenriqueSilva, Nuno Costa eJanuário, LuísRodrigues, Fernanda2022-12-20T11:05:32Zoai:ojs.www.actamedicaportuguesa.com:article/8493Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:36.236354Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015 Doença Invasiva Pneumocócica Pediátrica Antes da Vacinação Universal: 1995 - 2015 |
title |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015 |
spellingShingle |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015 Ferreira, Muriel Child Pneumococcal Infections Pneumococcal Vaccines Portugal Vaccines Conjugate Criança Infecções Pneumocócicas Portugal Vacinas Conjugadas Vacinas Pneumocócicas |
title_short |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015 |
title_full |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015 |
title_fullStr |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015 |
title_full_unstemmed |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015 |
title_sort |
Paediatric Invasive Pneumococcal Disease Before Universal Vaccination: 1995 - 2015 |
author |
Ferreira, Muriel |
author_facet |
Ferreira, Muriel Oliveira, Henrique Silva, Nuno Costa e Januário, Luís Rodrigues, Fernanda |
author_role |
author |
author2 |
Oliveira, Henrique Silva, Nuno Costa e Januário, Luís Rodrigues, Fernanda |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Muriel Oliveira, Henrique Silva, Nuno Costa e Januário, Luís Rodrigues, Fernanda |
dc.subject.por.fl_str_mv |
Child Pneumococcal Infections Pneumococcal Vaccines Portugal Vaccines Conjugate Criança Infecções Pneumocócicas Portugal Vacinas Conjugadas Vacinas Pneumocócicas |
topic |
Child Pneumococcal Infections Pneumococcal Vaccines Portugal Vaccines Conjugate Criança Infecções Pneumocócicas Portugal Vacinas Conjugadas Vacinas Pneumocócicas |
description |
Introduction: Pneumococcal conjugate vaccine was introduced in the private market in Portugal in 2001, reaching over the years a moderately high coverage. In July 2015, it was included in the National Immunisation Program. The aim of this study was to characterize invasive pneumococcal disease in a pediatric hospital before universal use of the vaccine.Material and Methods: Retrospective analysis of medical records of all children with Streptococcus pneumoniae identified by culture and/or molecular biology (available since 2008), in products obtained from sterile sites, from January 1995 to June 2015. We evaluated demographic, clinical and microbiological data. Serotype results are available since 2004.Results: Over those 20 years, 112 invasive pneumococcal disease cases were identified, with a median age of 15 months (1 month - 15 years). The median number of cases /year was 4, the highest between 2001 - 2002 (8/year) and 2007 - 2012 (7 - 11/year). The identification occurred mostly in blood culture (72), cerebrospinal fluid (24), pleural fluid (11) an others (5). The most frequent diagnoses were pneumonia (38%), occult bacteraemia (34%) and meningitis (21%). Over the period under review, there was an increase of pneumonia and slight increase of OB, with meningitis cases remaining relatively unchanged.Discussion: In the last two decades, there was no reduction in the number of cases of invasive pneumococcal disease. There was an increase in isolates from pneumonia and occult bacteraemia that might be due to the introduction of molecular biological methods for Streptococcus pneumoniae detection. Vaccine serotypes were predominant.Conclusion: This retrospective analysis before universal vaccination will contribute to evaluate the impact of vaccination in the Portuguese pediatric population. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493 oai:ojs.www.actamedicaportuguesa.com:article/8493 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/8493 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/5074 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/5365 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8911 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8912 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/8941 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/9224 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8493/9315 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2017 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2017 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf image/jpeg image/jpeg application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document image/jpeg |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 30 No. 6 (2017): June; 457-462 Acta Médica Portuguesa; Vol. 30 N.º 6 (2017): Junho; 457-462 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799130646667329536 |