Effect of aluminum on the non-enzymatic oxidation of dopamine.

Detalhes bibliográficos
Autor(a) principal: Marinho, C R
Data de Publicação: 1994
Outros Autores: Manso, C F
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984
Resumo: The effect of different concentrations of aluminum sulphate on the nonenzymatic oxidation of dopamine was studied in order to evaluate the action of this metal on neuromelanin synthesis. Data shows that under the studied conditions, aluminum partially inhibits dopamine self-oxidation, decreasing the formation of some intermediate compounds, namely dopaminequinone and dopaminochrome. If neuromelanins have a cytoprotective function in the central nervous system, possibly acting as intracellular scavengers of free radicals and redox metal ions, their decrease due to aluminum could be responsible for serious damage to neuronal tissues.
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spelling Effect of aluminum on the non-enzymatic oxidation of dopamine.Efeito do alumínio na oxidação não enzimática da dopamina.The effect of different concentrations of aluminum sulphate on the nonenzymatic oxidation of dopamine was studied in order to evaluate the action of this metal on neuromelanin synthesis. Data shows that under the studied conditions, aluminum partially inhibits dopamine self-oxidation, decreasing the formation of some intermediate compounds, namely dopaminequinone and dopaminochrome. If neuromelanins have a cytoprotective function in the central nervous system, possibly acting as intracellular scavengers of free radicals and redox metal ions, their decrease due to aluminum could be responsible for serious damage to neuronal tissues.The effect of different concentrations of aluminum sulphate on the nonenzymatic oxidation of dopamine was studied in order to evaluate the action of this metal on neuromelanin synthesis. Data shows that under the studied conditions, aluminum partially inhibits dopamine self-oxidation, decreasing the formation of some intermediate compounds, namely dopaminequinone and dopaminochrome. If neuromelanins have a cytoprotective function in the central nervous system, possibly acting as intracellular scavengers of free radicals and redox metal ions, their decrease due to aluminum could be responsible for serious damage to neuronal tissues.Ordem dos Médicos1994-11-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984oai:ojs.www.actamedicaportuguesa.com:article/2984Acta Médica Portuguesa; Vol. 7 No. 11 (1994): Novembro; 611-5Acta Médica Portuguesa; Vol. 7 N.º 11 (1994): Novembro; 611-51646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984/2329Marinho, C RManso, C Finfo:eu-repo/semantics/openAccess2022-12-20T11:01:28Zoai:ojs.www.actamedicaportuguesa.com:article/2984Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:05.449857Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of aluminum on the non-enzymatic oxidation of dopamine.
Efeito do alumínio na oxidação não enzimática da dopamina.
title Effect of aluminum on the non-enzymatic oxidation of dopamine.
spellingShingle Effect of aluminum on the non-enzymatic oxidation of dopamine.
Marinho, C R
title_short Effect of aluminum on the non-enzymatic oxidation of dopamine.
title_full Effect of aluminum on the non-enzymatic oxidation of dopamine.
title_fullStr Effect of aluminum on the non-enzymatic oxidation of dopamine.
title_full_unstemmed Effect of aluminum on the non-enzymatic oxidation of dopamine.
title_sort Effect of aluminum on the non-enzymatic oxidation of dopamine.
author Marinho, C R
author_facet Marinho, C R
Manso, C F
author_role author
author2 Manso, C F
author2_role author
dc.contributor.author.fl_str_mv Marinho, C R
Manso, C F
description The effect of different concentrations of aluminum sulphate on the nonenzymatic oxidation of dopamine was studied in order to evaluate the action of this metal on neuromelanin synthesis. Data shows that under the studied conditions, aluminum partially inhibits dopamine self-oxidation, decreasing the formation of some intermediate compounds, namely dopaminequinone and dopaminochrome. If neuromelanins have a cytoprotective function in the central nervous system, possibly acting as intracellular scavengers of free radicals and redox metal ions, their decrease due to aluminum could be responsible for serious damage to neuronal tissues.
publishDate 1994
dc.date.none.fl_str_mv 1994-11-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/2984
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2984/2329
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 7 No. 11 (1994): Novembro; 611-5
Acta Médica Portuguesa; Vol. 7 N.º 11 (1994): Novembro; 611-5
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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