Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2770 |
Resumo: | PURPOSE: To compare the thickness of all retinal layers between a nondiabetic group and diabetic patients without diabetic retinopathy (DR). METHODS: Cross-sectional study, in which all subjects underwent an ophthalmic examination including optical coherence tomography. After automatic retinal segmentation, each retinal layer thickness (eight separate layers and overall thickness) was calculated in all nine Early Treatment Diabetic Retinopathy Study (ETDRS) areas. The choroidal thickness (CT) also was measured at five locations. Generalized additive regression models were used to analyze the data. RESULTS: A total of 175 patients were recruited, 50 nondiabetic subjects and 125 diabetic patients without DR, stratified into three groups according to diabetes duration: group I (<5 years, n = 55), group II (5-10 years, n = 39), and group III (>10 years, n = 31). Overall, groups I and III of diabetic patients had a decrease in the photoreceptor layer (PR) thickness, when compared with the nondiabetic subjects in six ETDRS areas (P < 0.0007). Patients with more recent diagnosis (group I) had thinner PR than those with moderate duration (group II). Interestingly, patients with longer known disease (group III) had the thinnest PR values. There were no overall differences in the remaining retinal parameters. CONCLUSIONS: Retinal thickness profile is not linear throughout disease duration. Even in the absence of funduscopic disease, PR layer in diabetic patients seems to differ from nondiabetic subjects, thus suggesting that some form of neurodegeneration may take place before clinical signs of vascular problems arise. |
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Retinal Neurodegeneration in Diabetic Patients Without Diabetic RetinopathyAgedChoroidCross-Sectional StudiesDiabetes Mellitus, Type 2Diabetic RetinopathyFemaleFollow-Up StudiesHumansMaleOphthalmoscopyRetinaRetinal DegenerationRetrospective StudiesTomography, Optical CoherenceCHLC OFTPURPOSE: To compare the thickness of all retinal layers between a nondiabetic group and diabetic patients without diabetic retinopathy (DR). METHODS: Cross-sectional study, in which all subjects underwent an ophthalmic examination including optical coherence tomography. After automatic retinal segmentation, each retinal layer thickness (eight separate layers and overall thickness) was calculated in all nine Early Treatment Diabetic Retinopathy Study (ETDRS) areas. The choroidal thickness (CT) also was measured at five locations. Generalized additive regression models were used to analyze the data. RESULTS: A total of 175 patients were recruited, 50 nondiabetic subjects and 125 diabetic patients without DR, stratified into three groups according to diabetes duration: group I (<5 years, n = 55), group II (5-10 years, n = 39), and group III (>10 years, n = 31). Overall, groups I and III of diabetic patients had a decrease in the photoreceptor layer (PR) thickness, when compared with the nondiabetic subjects in six ETDRS areas (P < 0.0007). Patients with more recent diagnosis (group I) had thinner PR than those with moderate duration (group II). Interestingly, patients with longer known disease (group III) had the thinnest PR values. There were no overall differences in the remaining retinal parameters. CONCLUSIONS: Retinal thickness profile is not linear throughout disease duration. Even in the absence of funduscopic disease, PR layer in diabetic patients seems to differ from nondiabetic subjects, thus suggesting that some form of neurodegeneration may take place before clinical signs of vascular problems arise.Repositório do Centro Hospitalar Universitário de Lisboa Central, EPETavares Ferreira, JAlves, MDias-Santos, ACosta, LSantos, BCunha, JPPapoila, ALAbegão Pinto, L2017-10-24T14:48:31Z2016-11-012016-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2770engInvest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6455-646010.1167/iovs.16-20215info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:39:32Zoai:repositorio.chlc.min-saude.pt:10400.17/2770Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:06.207786Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy |
title |
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy |
spellingShingle |
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy Tavares Ferreira, J Aged Choroid Cross-Sectional Studies Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Follow-Up Studies Humans Male Ophthalmoscopy Retina Retinal Degeneration Retrospective Studies Tomography, Optical Coherence CHLC OFT |
title_short |
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy |
title_full |
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy |
title_fullStr |
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy |
title_full_unstemmed |
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy |
title_sort |
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy |
author |
Tavares Ferreira, J |
author_facet |
Tavares Ferreira, J Alves, M Dias-Santos, A Costa, L Santos, B Cunha, JP Papoila, AL Abegão Pinto, L |
author_role |
author |
author2 |
Alves, M Dias-Santos, A Costa, L Santos, B Cunha, JP Papoila, AL Abegão Pinto, L |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Tavares Ferreira, J Alves, M Dias-Santos, A Costa, L Santos, B Cunha, JP Papoila, AL Abegão Pinto, L |
dc.subject.por.fl_str_mv |
Aged Choroid Cross-Sectional Studies Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Follow-Up Studies Humans Male Ophthalmoscopy Retina Retinal Degeneration Retrospective Studies Tomography, Optical Coherence CHLC OFT |
topic |
Aged Choroid Cross-Sectional Studies Diabetes Mellitus, Type 2 Diabetic Retinopathy Female Follow-Up Studies Humans Male Ophthalmoscopy Retina Retinal Degeneration Retrospective Studies Tomography, Optical Coherence CHLC OFT |
description |
PURPOSE: To compare the thickness of all retinal layers between a nondiabetic group and diabetic patients without diabetic retinopathy (DR). METHODS: Cross-sectional study, in which all subjects underwent an ophthalmic examination including optical coherence tomography. After automatic retinal segmentation, each retinal layer thickness (eight separate layers and overall thickness) was calculated in all nine Early Treatment Diabetic Retinopathy Study (ETDRS) areas. The choroidal thickness (CT) also was measured at five locations. Generalized additive regression models were used to analyze the data. RESULTS: A total of 175 patients were recruited, 50 nondiabetic subjects and 125 diabetic patients without DR, stratified into three groups according to diabetes duration: group I (<5 years, n = 55), group II (5-10 years, n = 39), and group III (>10 years, n = 31). Overall, groups I and III of diabetic patients had a decrease in the photoreceptor layer (PR) thickness, when compared with the nondiabetic subjects in six ETDRS areas (P < 0.0007). Patients with more recent diagnosis (group I) had thinner PR than those with moderate duration (group II). Interestingly, patients with longer known disease (group III) had the thinnest PR values. There were no overall differences in the remaining retinal parameters. CONCLUSIONS: Retinal thickness profile is not linear throughout disease duration. Even in the absence of funduscopic disease, PR layer in diabetic patients seems to differ from nondiabetic subjects, thus suggesting that some form of neurodegeneration may take place before clinical signs of vascular problems arise. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01 2016-11-01T00:00:00Z 2017-10-24T14:48:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2770 |
url |
http://hdl.handle.net/10400.17/2770 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6455-6460 10.1167/iovs.16-20215 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131297083293696 |