Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination

Detalhes bibliográficos
Autor(a) principal: M'Bana, Viriato
Data de Publicação: 2022
Outros Autores: Lahree, Aparajita, Marques, Sofia, Slavic, Ksenija, Mota, Maria M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53162
Resumo: © 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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spelling Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite eliminationCell biologyMicrobial interactionsParasitology© 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Parasite-derived PVM-resident proteins are critical for complete parasite development inside hepatocytes, although the function of most of these proteins remains unknown. Here, we show that the upregulated in infectious sporozoites 4 (UIS4) protein, resident at the PVM, interacts with the host cell actin. By suppressing filamentous actin formation, UIS4 avoids parasite elimination. Host cell actin dynamics increases around UIS4-deficient parasites, which is associated with subsequent parasite elimination. Notably, parasite elimination is impaired significantly by the inhibition of host myosin-II, possibly through relieving the compression generated by actomyosin complexes at the host-parasite interface. Together, these data reveal that UIS4 has a critical role in the evasion of host defensive mechanisms, enabling hence EEF survival and development.This work was supported by grants from the Fundação para a Ciência e a Tecnologia (DRIVER-LISBOA-01-0145-FEDER-030751) and “la Caixa” Foundation (under the agreement HR17/52150010) to M.M.M. and Calouste Gulbenkian Foundation short project to V.M’B. and M.M.M.. V.M’B., A.L., and S.M. were sponsored by Fundação para a Ciência e a Tecnologia (SFRH/BD/113750/2015, PD/BD/114036/2015 and DL57/2016/CP1451/CT0010 respectively).ElsevierRepositório da Universidade de LisboaM'Bana, ViriatoLahree, AparajitaMarques, SofiaSlavic, KsenijaMota, Maria M.2022-05-24T14:46:22Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53162engiScience. 2022 Apr 22;25(5):10428110.1016/j.isci.2022.1042812589-0042info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:49Zoai:repositorio.ul.pt:10451/53162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:07.959818Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination
title Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination
spellingShingle Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination
M'Bana, Viriato
Cell biology
Microbial interactions
Parasitology
title_short Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination
title_full Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination
title_fullStr Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination
title_full_unstemmed Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination
title_sort Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination
author M'Bana, Viriato
author_facet M'Bana, Viriato
Lahree, Aparajita
Marques, Sofia
Slavic, Ksenija
Mota, Maria M.
author_role author
author2 Lahree, Aparajita
Marques, Sofia
Slavic, Ksenija
Mota, Maria M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv M'Bana, Viriato
Lahree, Aparajita
Marques, Sofia
Slavic, Ksenija
Mota, Maria M.
dc.subject.por.fl_str_mv Cell biology
Microbial interactions
Parasitology
topic Cell biology
Microbial interactions
Parasitology
description © 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2022
dc.date.none.fl_str_mv 2022-05-24T14:46:22Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53162
url http://hdl.handle.net/10451/53162
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv iScience. 2022 Apr 22;25(5):104281
10.1016/j.isci.2022.104281
2589-0042
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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