Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/27768 |
Resumo: | Cancer research is considered an increasingly logical science with great potential for the development of new treatment options. Advances in nanomedicine have resulted in rapid progress of nanomaterials development with considerable potential in cancer treatment. One alternative treatment option is the use of magnetic nanoparticles (mNPs) for the induction of intracellular hyperthermia. The theory behind hyperthermia is to kill cancer cells without the use of drugs (chemotherapy) or radiation (radiotherapy) just by increasing temperature in tumor site. This idea is based on higher sensitivity of cancer cells to temperature oscillations when compared to normal cells, therefore decreasing the side effects. In this dissertation project, the main objective is the internalization of magnetic nanoparticles in two types of breast cancer cell lines, where one of them express the cell-surface carbohydrate antigen sialyl-Tn (STn) which is not observed in normal healthy tissues. For these reasons, another purpose of this thesis project is the development of a complex monoclonal antibody-conjugated mNPs against sialyl Tn that will confer specificity to the whole system due its action in the specific target cells. In this context, we will have surface iron oxide nanoparticles and antibody-conjugated mNPs that will be used as heat producers under the application of an external magnetic field, leading to breast cancer cells death. |
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Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell LinesCancerMagnetic hyperthermiaIron oxide nanoparticlesCellular internalizationSialyl-Tn antigenDomínio/Área Científica::Engenharia e Tecnologia::Engenharia QuímicaCancer research is considered an increasingly logical science with great potential for the development of new treatment options. Advances in nanomedicine have resulted in rapid progress of nanomaterials development with considerable potential in cancer treatment. One alternative treatment option is the use of magnetic nanoparticles (mNPs) for the induction of intracellular hyperthermia. The theory behind hyperthermia is to kill cancer cells without the use of drugs (chemotherapy) or radiation (radiotherapy) just by increasing temperature in tumor site. This idea is based on higher sensitivity of cancer cells to temperature oscillations when compared to normal cells, therefore decreasing the side effects. In this dissertation project, the main objective is the internalization of magnetic nanoparticles in two types of breast cancer cell lines, where one of them express the cell-surface carbohydrate antigen sialyl-Tn (STn) which is not observed in normal healthy tissues. For these reasons, another purpose of this thesis project is the development of a complex monoclonal antibody-conjugated mNPs against sialyl Tn that will confer specificity to the whole system due its action in the specific target cells. In this context, we will have surface iron oxide nanoparticles and antibody-conjugated mNPs that will be used as heat producers under the application of an external magnetic field, leading to breast cancer cells death.Soares, PaulaRUNChaparro, Catarina Isabel Parente2020-10-01T00:30:29Z2017-122017-122017-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/27768enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:14:42Zoai:run.unl.pt:10362/27768Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:44.829972Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines |
title |
Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines |
spellingShingle |
Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines Chaparro, Catarina Isabel Parente Cancer Magnetic hyperthermia Iron oxide nanoparticles Cellular internalization Sialyl-Tn antigen Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química |
title_short |
Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines |
title_full |
Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines |
title_fullStr |
Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines |
title_full_unstemmed |
Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines |
title_sort |
Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines |
author |
Chaparro, Catarina Isabel Parente |
author_facet |
Chaparro, Catarina Isabel Parente |
author_role |
author |
dc.contributor.none.fl_str_mv |
Soares, Paula RUN |
dc.contributor.author.fl_str_mv |
Chaparro, Catarina Isabel Parente |
dc.subject.por.fl_str_mv |
Cancer Magnetic hyperthermia Iron oxide nanoparticles Cellular internalization Sialyl-Tn antigen Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química |
topic |
Cancer Magnetic hyperthermia Iron oxide nanoparticles Cellular internalization Sialyl-Tn antigen Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química |
description |
Cancer research is considered an increasingly logical science with great potential for the development of new treatment options. Advances in nanomedicine have resulted in rapid progress of nanomaterials development with considerable potential in cancer treatment. One alternative treatment option is the use of magnetic nanoparticles (mNPs) for the induction of intracellular hyperthermia. The theory behind hyperthermia is to kill cancer cells without the use of drugs (chemotherapy) or radiation (radiotherapy) just by increasing temperature in tumor site. This idea is based on higher sensitivity of cancer cells to temperature oscillations when compared to normal cells, therefore decreasing the side effects. In this dissertation project, the main objective is the internalization of magnetic nanoparticles in two types of breast cancer cell lines, where one of them express the cell-surface carbohydrate antigen sialyl-Tn (STn) which is not observed in normal healthy tissues. For these reasons, another purpose of this thesis project is the development of a complex monoclonal antibody-conjugated mNPs against sialyl Tn that will confer specificity to the whole system due its action in the specific target cells. In this context, we will have surface iron oxide nanoparticles and antibody-conjugated mNPs that will be used as heat producers under the application of an external magnetic field, leading to breast cancer cells death. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12 2017-12 2017-12-01T00:00:00Z 2020-10-01T00:30:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/27768 |
url |
http://hdl.handle.net/10362/27768 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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