Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines

Detalhes bibliográficos
Autor(a) principal: Chaparro, Catarina Isabel Parente
Data de Publicação: 2017
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/27768
Resumo: Cancer research is considered an increasingly logical science with great potential for the development of new treatment options. Advances in nanomedicine have resulted in rapid progress of nanomaterials development with considerable potential in cancer treatment. One alternative treatment option is the use of magnetic nanoparticles (mNPs) for the induction of intracellular hyperthermia. The theory behind hyperthermia is to kill cancer cells without the use of drugs (chemotherapy) or radiation (radiotherapy) just by increasing temperature in tumor site. This idea is based on higher sensitivity of cancer cells to temperature oscillations when compared to normal cells, therefore decreasing the side effects. In this dissertation project, the main objective is the internalization of magnetic nanoparticles in two types of breast cancer cell lines, where one of them express the cell-surface carbohydrate antigen sialyl-Tn (STn) which is not observed in normal healthy tissues. For these reasons, another purpose of this thesis project is the development of a complex monoclonal antibody-conjugated mNPs against sialyl Tn that will confer specificity to the whole system due its action in the specific target cells. In this context, we will have surface iron oxide nanoparticles and antibody-conjugated mNPs that will be used as heat producers under the application of an external magnetic field, leading to breast cancer cells death.
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spelling Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell LinesCancerMagnetic hyperthermiaIron oxide nanoparticlesCellular internalizationSialyl-Tn antigenDomínio/Área Científica::Engenharia e Tecnologia::Engenharia QuímicaCancer research is considered an increasingly logical science with great potential for the development of new treatment options. Advances in nanomedicine have resulted in rapid progress of nanomaterials development with considerable potential in cancer treatment. One alternative treatment option is the use of magnetic nanoparticles (mNPs) for the induction of intracellular hyperthermia. The theory behind hyperthermia is to kill cancer cells without the use of drugs (chemotherapy) or radiation (radiotherapy) just by increasing temperature in tumor site. This idea is based on higher sensitivity of cancer cells to temperature oscillations when compared to normal cells, therefore decreasing the side effects. In this dissertation project, the main objective is the internalization of magnetic nanoparticles in two types of breast cancer cell lines, where one of them express the cell-surface carbohydrate antigen sialyl-Tn (STn) which is not observed in normal healthy tissues. For these reasons, another purpose of this thesis project is the development of a complex monoclonal antibody-conjugated mNPs against sialyl Tn that will confer specificity to the whole system due its action in the specific target cells. In this context, we will have surface iron oxide nanoparticles and antibody-conjugated mNPs that will be used as heat producers under the application of an external magnetic field, leading to breast cancer cells death.Soares, PaulaRUNChaparro, Catarina Isabel Parente2020-10-01T00:30:29Z2017-122017-122017-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/27768enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:14:42Zoai:run.unl.pt:10362/27768Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:44.829972Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
title Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
spellingShingle Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
Chaparro, Catarina Isabel Parente
Cancer
Magnetic hyperthermia
Iron oxide nanoparticles
Cellular internalization
Sialyl-Tn antigen
Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química
title_short Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
title_full Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
title_fullStr Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
title_full_unstemmed Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
title_sort Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines
author Chaparro, Catarina Isabel Parente
author_facet Chaparro, Catarina Isabel Parente
author_role author
dc.contributor.none.fl_str_mv Soares, Paula
RUN
dc.contributor.author.fl_str_mv Chaparro, Catarina Isabel Parente
dc.subject.por.fl_str_mv Cancer
Magnetic hyperthermia
Iron oxide nanoparticles
Cellular internalization
Sialyl-Tn antigen
Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química
topic Cancer
Magnetic hyperthermia
Iron oxide nanoparticles
Cellular internalization
Sialyl-Tn antigen
Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química
description Cancer research is considered an increasingly logical science with great potential for the development of new treatment options. Advances in nanomedicine have resulted in rapid progress of nanomaterials development with considerable potential in cancer treatment. One alternative treatment option is the use of magnetic nanoparticles (mNPs) for the induction of intracellular hyperthermia. The theory behind hyperthermia is to kill cancer cells without the use of drugs (chemotherapy) or radiation (radiotherapy) just by increasing temperature in tumor site. This idea is based on higher sensitivity of cancer cells to temperature oscillations when compared to normal cells, therefore decreasing the side effects. In this dissertation project, the main objective is the internalization of magnetic nanoparticles in two types of breast cancer cell lines, where one of them express the cell-surface carbohydrate antigen sialyl-Tn (STn) which is not observed in normal healthy tissues. For these reasons, another purpose of this thesis project is the development of a complex monoclonal antibody-conjugated mNPs against sialyl Tn that will confer specificity to the whole system due its action in the specific target cells. In this context, we will have surface iron oxide nanoparticles and antibody-conjugated mNPs that will be used as heat producers under the application of an external magnetic field, leading to breast cancer cells death.
publishDate 2017
dc.date.none.fl_str_mv 2017-12
2017-12
2017-12-01T00:00:00Z
2020-10-01T00:30:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/27768
url http://hdl.handle.net/10362/27768
dc.language.iso.fl_str_mv eng
language eng
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dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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