Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study

Detalhes bibliográficos
Autor(a) principal: Dias, Juliana R.
Data de Publicação: 2022
Outros Autores: Sousa, Aureliana, Augusto, Ana, Bártolo, Paulo J., Granja, Pedro L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/8724
Resumo: This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) through the following projects: CDRSP: UIDB/04044/2020, UIDP/04044/2020 and MARE: UIDB/04292/2020 and UIDP/04292/2020. This study was also supported by PAMI-ROTEIRO/0328/2013 (No. 022158), MATIS (CENTRO-01-0145-FEDER-000014-3362), SpinningTNT (POCI-01-02B7-FEDER-069285), and the project LA/P/0069/2020 granted to the Associate Laboratory ARNET.
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spelling Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo studyPolycaprolactoneEletrospinning nanofibersDegradationEnzymaticThis work was supported by the Fundação para a Ciência e a Tecnologia (FCT) through the following projects: CDRSP: UIDB/04044/2020, UIDP/04044/2020 and MARE: UIDB/04292/2020 and UIDP/04292/2020. This study was also supported by PAMI-ROTEIRO/0328/2013 (No. 022158), MATIS (CENTRO-01-0145-FEDER-000014-3362), SpinningTNT (POCI-01-02B7-FEDER-069285), and the project LA/P/0069/2020 granted to the Associate Laboratory ARNET.Polycaprolactone (PCL) is widely used in tissue engineering due to its interesting properties, namely biocompatibility, biodegradability, elastic nature, availability, cost efficacy, and the approval of health authorities such as the American Food and Drug Administration (FDA). The PCL degradation rate is not the most adequate for specific applications such as skin regeneration due to the hydrophobic nature of bulk PCL. However, PCL electrospun fiber meshes, due to their low diameters resulting in high surface area, are expected to exhibit a fast degradation rate. In this work, in vitro and in vivo degradation studies were performed over 90 days to evaluate the potential of electrospun PCL as a wound dressing. Enzymatic and hydrolytic degradation studies in vitro, performed in a static medium, demonstrated the influence of lipase, which promoted a rate of degradation of 97% for PCL meshes. In an in vivo scenario, the degradation was slower, although the samples were not rejected, and were well-integrated in the surrounding tissues inside the subcutaneous pockets specifically created.MDPIIC-OnlineDias, Juliana R.Sousa, AurelianaAugusto, AnaBártolo, Paulo J.Granja, Pedro L.2023-08-23T10:32:11Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8724engDias, J.R.; Sousa, A.; Augusto, A.; Bártolo, P.J.; Granja, P.L. Electrospun Polycaprolactone (PCL) Degradation: An In Vitro and In Vivo Study. Polymers 2022, 14, 3397. https://doi.org/10.3390/ polym141633972073-436010.3390/polym14163397info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-26T18:26:16Zoai:iconline.ipleiria.pt:10400.8/8724Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-26T18:26:16Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study
title Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study
spellingShingle Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study
Dias, Juliana R.
Polycaprolactone
Eletrospinning nanofibers
Degradation
Enzymatic
title_short Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study
title_full Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study
title_fullStr Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study
title_full_unstemmed Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study
title_sort Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study
author Dias, Juliana R.
author_facet Dias, Juliana R.
Sousa, Aureliana
Augusto, Ana
Bártolo, Paulo J.
Granja, Pedro L.
author_role author
author2 Sousa, Aureliana
Augusto, Ana
Bártolo, Paulo J.
Granja, Pedro L.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Dias, Juliana R.
Sousa, Aureliana
Augusto, Ana
Bártolo, Paulo J.
Granja, Pedro L.
dc.subject.por.fl_str_mv Polycaprolactone
Eletrospinning nanofibers
Degradation
Enzymatic
topic Polycaprolactone
Eletrospinning nanofibers
Degradation
Enzymatic
description This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) through the following projects: CDRSP: UIDB/04044/2020, UIDP/04044/2020 and MARE: UIDB/04292/2020 and UIDP/04292/2020. This study was also supported by PAMI-ROTEIRO/0328/2013 (No. 022158), MATIS (CENTRO-01-0145-FEDER-000014-3362), SpinningTNT (POCI-01-02B7-FEDER-069285), and the project LA/P/0069/2020 granted to the Associate Laboratory ARNET.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-08-23T10:32:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/8724
url http://hdl.handle.net/10400.8/8724
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dias, J.R.; Sousa, A.; Augusto, A.; Bártolo, P.J.; Granja, P.L. Electrospun Polycaprolactone (PCL) Degradation: An In Vitro and In Vivo Study. Polymers 2022, 14, 3397. https://doi.org/10.3390/ polym14163397
2073-4360
10.3390/polym14163397
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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