Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109301 https://doi.org/10.1016/j.redox.2015.08.016 |
Resumo: | Within the last twenty years the view on reactive oxygen species (ROS) has changed; they are no longer only considered to be harmful but also necessary for cellular communication and homeostasis in different organisms ranging from bacteria to mammals. In the latter, ROS were shown to modulate diverse physiological processes including the regulation of growth factor signaling, the hypoxic response, inflammation and the immune response. During the last 60-100 years the life style, at least in the Western world, has changed enormously. This became obvious with an increase in caloric intake, decreased energy expenditure as well as the appearance of alcoholism and smoking; These changes were shown to contribute to generation of ROS which are, at least in part, associated with the occurrence of several chronic diseases like adiposity, atherosclerosis, type II diabetes, and cancer. In this review we discuss aspects and problems on the role of intracellular ROS formation and nutrition with the link to diseases and their problematic therapeutical issues. |
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Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?FreeradicalsDietsOxygenMetabolismDiseasesMitochondriaHypoxiaDiabetesObesityAnimalsAtherosclerosisDiabetes Mellitus, Type 2Energy MetabolismGene Expression RegulationHumansHypoxiaMitogen-Activated Protein KinasesNF-kappa BNeoplasmsNucleocytoplasmic Transport ProteinsNutritional RequirementsObesityOxidative StressPregnancy ProteinsReactive Oxygen SpeciesSignal TransductionWithin the last twenty years the view on reactive oxygen species (ROS) has changed; they are no longer only considered to be harmful but also necessary for cellular communication and homeostasis in different organisms ranging from bacteria to mammals. In the latter, ROS were shown to modulate diverse physiological processes including the regulation of growth factor signaling, the hypoxic response, inflammation and the immune response. During the last 60-100 years the life style, at least in the Western world, has changed enormously. This became obvious with an increase in caloric intake, decreased energy expenditure as well as the appearance of alcoholism and smoking; These changes were shown to contribute to generation of ROS which are, at least in part, associated with the occurrence of several chronic diseases like adiposity, atherosclerosis, type II diabetes, and cancer. In this review we discuss aspects and problems on the role of intracellular ROS formation and nutrition with the link to diseases and their problematic therapeutical issues.Elsevier2015-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109301http://hdl.handle.net/10316/109301https://doi.org/10.1016/j.redox.2015.08.016eng22132317Görlach, AgnesDimova, Elitsa Y.Petry, AndreasMartínez-Ruiz, AntonioHernansanz-Agustín, PabloRolo, Anabela P.Palmeira, Carlos M.Kietzmann, Thomasinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-09T11:12:23Zoai:estudogeral.uc.pt:10316/109301Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:30.555047Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? |
title |
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? |
spellingShingle |
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? Görlach, Agnes Freeradicals Diets Oxygen Metabolism Diseases Mitochondria Hypoxia Diabetes Obesity Animals Atherosclerosis Diabetes Mellitus, Type 2 Energy Metabolism Gene Expression Regulation Humans Hypoxia Mitogen-Activated Protein Kinases NF-kappa B Neoplasms Nucleocytoplasmic Transport Proteins Nutritional Requirements Obesity Oxidative Stress Pregnancy Proteins Reactive Oxygen Species Signal Transduction |
title_short |
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? |
title_full |
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? |
title_fullStr |
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? |
title_full_unstemmed |
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? |
title_sort |
Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? |
author |
Görlach, Agnes |
author_facet |
Görlach, Agnes Dimova, Elitsa Y. Petry, Andreas Martínez-Ruiz, Antonio Hernansanz-Agustín, Pablo Rolo, Anabela P. Palmeira, Carlos M. Kietzmann, Thomas |
author_role |
author |
author2 |
Dimova, Elitsa Y. Petry, Andreas Martínez-Ruiz, Antonio Hernansanz-Agustín, Pablo Rolo, Anabela P. Palmeira, Carlos M. Kietzmann, Thomas |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Görlach, Agnes Dimova, Elitsa Y. Petry, Andreas Martínez-Ruiz, Antonio Hernansanz-Agustín, Pablo Rolo, Anabela P. Palmeira, Carlos M. Kietzmann, Thomas |
dc.subject.por.fl_str_mv |
Freeradicals Diets Oxygen Metabolism Diseases Mitochondria Hypoxia Diabetes Obesity Animals Atherosclerosis Diabetes Mellitus, Type 2 Energy Metabolism Gene Expression Regulation Humans Hypoxia Mitogen-Activated Protein Kinases NF-kappa B Neoplasms Nucleocytoplasmic Transport Proteins Nutritional Requirements Obesity Oxidative Stress Pregnancy Proteins Reactive Oxygen Species Signal Transduction |
topic |
Freeradicals Diets Oxygen Metabolism Diseases Mitochondria Hypoxia Diabetes Obesity Animals Atherosclerosis Diabetes Mellitus, Type 2 Energy Metabolism Gene Expression Regulation Humans Hypoxia Mitogen-Activated Protein Kinases NF-kappa B Neoplasms Nucleocytoplasmic Transport Proteins Nutritional Requirements Obesity Oxidative Stress Pregnancy Proteins Reactive Oxygen Species Signal Transduction |
description |
Within the last twenty years the view on reactive oxygen species (ROS) has changed; they are no longer only considered to be harmful but also necessary for cellular communication and homeostasis in different organisms ranging from bacteria to mammals. In the latter, ROS were shown to modulate diverse physiological processes including the regulation of growth factor signaling, the hypoxic response, inflammation and the immune response. During the last 60-100 years the life style, at least in the Western world, has changed enormously. This became obvious with an increase in caloric intake, decreased energy expenditure as well as the appearance of alcoholism and smoking; These changes were shown to contribute to generation of ROS which are, at least in part, associated with the occurrence of several chronic diseases like adiposity, atherosclerosis, type II diabetes, and cancer. In this review we discuss aspects and problems on the role of intracellular ROS formation and nutrition with the link to diseases and their problematic therapeutical issues. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109301 http://hdl.handle.net/10316/109301 https://doi.org/10.1016/j.redox.2015.08.016 |
url |
http://hdl.handle.net/10316/109301 https://doi.org/10.1016/j.redox.2015.08.016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
22132317 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799134137506856960 |