Time to harmonize dengue nomenclature and classification
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/116696 |
Resumo: | Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus's ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV's current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies. |
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Time to harmonize dengue nomenclature and classificationClassificationDengue virusDiversityNomenclatureSDG 3 - Good Health and Well-beingDengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus's ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV's current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)TB, HIV and opportunistic diseases and pathogens (THOP)RUNCuypers, LizePieter J.K., Libin,Peter, Simmonds,Nowé, AnnJorge Luis, Muñoz-Jordán,Luiz Carlos, Júnior Alcântara,Vandamme, AMGilberto A., Santiago,Theys, Kristof2021-05-02T22:40:25Z2018-10-182018-10-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://hdl.handle.net/10362/116696eng1999-4915PURE: 11377097https://doi.org/10.3390/v10100569info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:22Zoai:run.unl.pt:10362/116696Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:12.683089Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Time to harmonize dengue nomenclature and classification |
title |
Time to harmonize dengue nomenclature and classification |
spellingShingle |
Time to harmonize dengue nomenclature and classification Cuypers, Lize Classification Dengue virus Diversity Nomenclature SDG 3 - Good Health and Well-being |
title_short |
Time to harmonize dengue nomenclature and classification |
title_full |
Time to harmonize dengue nomenclature and classification |
title_fullStr |
Time to harmonize dengue nomenclature and classification |
title_full_unstemmed |
Time to harmonize dengue nomenclature and classification |
title_sort |
Time to harmonize dengue nomenclature and classification |
author |
Cuypers, Lize |
author_facet |
Cuypers, Lize Pieter J.K., Libin, Peter, Simmonds, Nowé, Ann Jorge Luis, Muñoz-Jordán, Luiz Carlos, Júnior Alcântara, Vandamme, AM Gilberto A., Santiago, Theys, Kristof |
author_role |
author |
author2 |
Pieter J.K., Libin, Peter, Simmonds, Nowé, Ann Jorge Luis, Muñoz-Jordán, Luiz Carlos, Júnior Alcântara, Vandamme, AM Gilberto A., Santiago, Theys, Kristof |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) TB, HIV and opportunistic diseases and pathogens (THOP) RUN |
dc.contributor.author.fl_str_mv |
Cuypers, Lize Pieter J.K., Libin, Peter, Simmonds, Nowé, Ann Jorge Luis, Muñoz-Jordán, Luiz Carlos, Júnior Alcântara, Vandamme, AM Gilberto A., Santiago, Theys, Kristof |
dc.subject.por.fl_str_mv |
Classification Dengue virus Diversity Nomenclature SDG 3 - Good Health and Well-being |
topic |
Classification Dengue virus Diversity Nomenclature SDG 3 - Good Health and Well-being |
description |
Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus's ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV's current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-18 2018-10-18T00:00:00Z 2021-05-02T22:40:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/116696 |
url |
http://hdl.handle.net/10362/116696 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1999-4915 PURE: 11377097 https://doi.org/10.3390/v10100569 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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7 application/pdf |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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