Optimal design of thedes based on perillyl alcohol and ibuprofen

Detalhes bibliográficos
Autor(a) principal: Silva, Eduardo
Data de Publicação: 2020
Outros Autores: Oliveira, Filipe, Silva, Joana M., Matias, Ana, Reis, Rui L., Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/121384
Resumo: PTDC/BBB-490 EBB/1676/2014 PTDC/CTM-CTM/29813/2017 SFHR/BD/143902/2019 SFRH/BPD/116779/2016
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spelling Optimal design of thedes based on perillyl alcohol and ibuprofenActive pharmaceutical ingredientsAnticancer propertiesAntimicrobial propertiesGreen chemistryNatural moleculesTherapeutic deep eutectic systemsPharmaceutical ScienceSDG 3 - Good Health and Well-beingPTDC/BBB-490 EBB/1676/2014 PTDC/CTM-CTM/29813/2017 SFHR/BD/143902/2019 SFRH/BPD/116779/2016Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratios. Our comprehensive strategy includes the characterization of their thermal and structural behavior to identify the molar ratios that successfully form deep eutectic systems. The in vitro solubility of the different systems prepared has demonstrated that, unlike other reported examples, the presence of the terpene did not affect the solubility of the anti-inflammatory agent in a physiological simulated media. The biological performance of the systems was studied in terms of their antimicrobial activity against a wide panel of microorganisms. The examined THEDES showed relevant antimicrobial activity against all tested microbial strains, with the exception of P. aeruginosa. A synergistic effect from the combination of POH and IBU as a eutectic system was verified. Furthermore, the cytotoxic profile of these eutectic systems towards colorectal cancer (CRC) in vitro cell models was also evaluated. The results provide the indication that the cell viability varies in a dose-dependent manner, with a selective THEDES action towards CRC cells. With tunable bioactivities in a ratio-dependent manner, THEDES enhanced the antimicrobial and anticancer properties, representing a possible alternative to conventional therapies. Therefore, this study provides foreseeable indications about the utility of THEDES based on POH and IBU as strong candidates for novel active pharmaceutical systems.DQ - Departamento de QuímicaLAQV@REQUIMTERUNSilva, EduardoOliveira, FilipeSilva, Joana M.Matias, AnaReis, Rui L.Duarte, Ana Rita C.2021-07-20T22:20:13Z2020-11-202020-11-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/121384eng1999-4923PURE: 32670749https://doi.org/10.3390/pharmaceutics12111121info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:03:42Zoai:run.unl.pt:10362/121384Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:35.792124Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Optimal design of thedes based on perillyl alcohol and ibuprofen
title Optimal design of thedes based on perillyl alcohol and ibuprofen
spellingShingle Optimal design of thedes based on perillyl alcohol and ibuprofen
Silva, Eduardo
Active pharmaceutical ingredients
Anticancer properties
Antimicrobial properties
Green chemistry
Natural molecules
Therapeutic deep eutectic systems
Pharmaceutical Science
SDG 3 - Good Health and Well-being
title_short Optimal design of thedes based on perillyl alcohol and ibuprofen
title_full Optimal design of thedes based on perillyl alcohol and ibuprofen
title_fullStr Optimal design of thedes based on perillyl alcohol and ibuprofen
title_full_unstemmed Optimal design of thedes based on perillyl alcohol and ibuprofen
title_sort Optimal design of thedes based on perillyl alcohol and ibuprofen
author Silva, Eduardo
author_facet Silva, Eduardo
Oliveira, Filipe
Silva, Joana M.
Matias, Ana
Reis, Rui L.
Duarte, Ana Rita C.
author_role author
author2 Oliveira, Filipe
Silva, Joana M.
Matias, Ana
Reis, Rui L.
Duarte, Ana Rita C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Silva, Eduardo
Oliveira, Filipe
Silva, Joana M.
Matias, Ana
Reis, Rui L.
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Active pharmaceutical ingredients
Anticancer properties
Antimicrobial properties
Green chemistry
Natural molecules
Therapeutic deep eutectic systems
Pharmaceutical Science
SDG 3 - Good Health and Well-being
topic Active pharmaceutical ingredients
Anticancer properties
Antimicrobial properties
Green chemistry
Natural molecules
Therapeutic deep eutectic systems
Pharmaceutical Science
SDG 3 - Good Health and Well-being
description PTDC/BBB-490 EBB/1676/2014 PTDC/CTM-CTM/29813/2017 SFHR/BD/143902/2019 SFRH/BPD/116779/2016
publishDate 2020
dc.date.none.fl_str_mv 2020-11-20
2020-11-20T00:00:00Z
2021-07-20T22:20:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/121384
url http://hdl.handle.net/10362/121384
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
PURE: 32670749
https://doi.org/10.3390/pharmaceutics12111121
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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