Petechiae in the newborn: A sign to consider
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.25753/BirthGrowthMJ.v32.i2.25163 |
Resumo: | Neonatal alloimmune thrombocytopenia (NAIT) occurs when the mother develops antiplatelet antibodies against fetal platelets and is confirmed by the presence of maternal antihuman platelet antibodies. A full-term newborn from a first pregnancy without complications was routinely examined on the first day of life. The newborn appeared well and had multiple petechiae on the axillary, inguinal, and popliteal folds and on the lower abdomen, with no other findings. Blood work revealed thrombocytopenia of 28,000/ul with a normal remaining hemogram and negative C-reactive protein. Because of the suspicion of NAIT, an intravenous dose of immunoglobulin was administered with a subsequent increase in platelet count. The diagnosis was confirmed on day 5 with the detection of maternal antiplatelet anti-HPA-1a alloantibodies. A thorough physical examination of the newborn is essential, as some serious conditions may present with subtle changes. NAIT should be considered in the differential diagnosis of isolated petechiae of the newborn. |
id |
RCAP_ef3d6d94ba8c3e7895169ee60556042a |
---|---|
oai_identifier_str |
oai:ojs.revistas.rcaap.pt:article/25163 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Petechiae in the newborn: A sign to considerPetéquias no recém-nascido: Um sinal a considerarImaging CasesNeonatal alloimmune thrombocytopenia (NAIT) occurs when the mother develops antiplatelet antibodies against fetal platelets and is confirmed by the presence of maternal antihuman platelet antibodies. A full-term newborn from a first pregnancy without complications was routinely examined on the first day of life. The newborn appeared well and had multiple petechiae on the axillary, inguinal, and popliteal folds and on the lower abdomen, with no other findings. Blood work revealed thrombocytopenia of 28,000/ul with a normal remaining hemogram and negative C-reactive protein. Because of the suspicion of NAIT, an intravenous dose of immunoglobulin was administered with a subsequent increase in platelet count. The diagnosis was confirmed on day 5 with the detection of maternal antiplatelet anti-HPA-1a alloantibodies. A thorough physical examination of the newborn is essential, as some serious conditions may present with subtle changes. NAIT should be considered in the differential diagnosis of isolated petechiae of the newborn.A trombocitopenia neonatal aloimune (TNA) ocorre quando a mãe produz anticorpos anti-plaquetários contra plaquetas fetais e é confirmada pela presença de anticorpos anti-plaquetários maternos. Um recém-nascido de termo fruto de uma primeira gravidez sem complicações foi observado num exame de rotina no 1º dia de vida. A criança apresentava bom estado geral e múltiplas petéquias nas pregas inguinais, axilares e poplíteas e na região abdominal inferior, sem outras alterações. O hemograma revelou trombocitopenia de 28,000/uL sem outras alterações e proteína C-reativa negativa. Devido à suspeita de TNA, foi administrada imunoglobulina endovenosa, com aumento subsequente da contagem plaquetária. O diagnóstico foi confirmado ao quinto dia com a presença de aloanticorpos anti-plaquetários anti-HPA-1a maternos. Dado que certas doenças graves podem apresentar-se com alterações subtis, é fundamental a realização de um exame objetivo exaustivo do recém-nascido . A TNA deve ser considerada no diagnóstico diferencial de petéquias isoladas no recém-nascido.Centro Hospitalar Universitário de Santo António2023-09-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.25753/BirthGrowthMJ.v32.i2.25163eng2183-9417Gaia, Maria JoãoBrandão Silva, JoanaCapela, MarianaPinto, Ruiinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-21T17:00:22Zoai:ojs.revistas.rcaap.pt:article/25163Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:29:16.235813Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Petechiae in the newborn: A sign to consider Petéquias no recém-nascido: Um sinal a considerar |
title |
Petechiae in the newborn: A sign to consider |
spellingShingle |
Petechiae in the newborn: A sign to consider Gaia, Maria João Imaging Cases |
title_short |
Petechiae in the newborn: A sign to consider |
title_full |
Petechiae in the newborn: A sign to consider |
title_fullStr |
Petechiae in the newborn: A sign to consider |
title_full_unstemmed |
Petechiae in the newborn: A sign to consider |
title_sort |
Petechiae in the newborn: A sign to consider |
author |
Gaia, Maria João |
author_facet |
Gaia, Maria João Brandão Silva, Joana Capela, Mariana Pinto, Rui |
author_role |
author |
author2 |
Brandão Silva, Joana Capela, Mariana Pinto, Rui |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gaia, Maria João Brandão Silva, Joana Capela, Mariana Pinto, Rui |
dc.subject.por.fl_str_mv |
Imaging Cases |
topic |
Imaging Cases |
description |
Neonatal alloimmune thrombocytopenia (NAIT) occurs when the mother develops antiplatelet antibodies against fetal platelets and is confirmed by the presence of maternal antihuman platelet antibodies. A full-term newborn from a first pregnancy without complications was routinely examined on the first day of life. The newborn appeared well and had multiple petechiae on the axillary, inguinal, and popliteal folds and on the lower abdomen, with no other findings. Blood work revealed thrombocytopenia of 28,000/ul with a normal remaining hemogram and negative C-reactive protein. Because of the suspicion of NAIT, an intravenous dose of immunoglobulin was administered with a subsequent increase in platelet count. The diagnosis was confirmed on day 5 with the detection of maternal antiplatelet anti-HPA-1a alloantibodies. A thorough physical examination of the newborn is essential, as some serious conditions may present with subtle changes. NAIT should be considered in the differential diagnosis of isolated petechiae of the newborn. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.25753/BirthGrowthMJ.v32.i2.25163 |
url |
https://doi.org/10.25753/BirthGrowthMJ.v32.i2.25163 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2183-9417 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Centro Hospitalar Universitário de Santo António |
publisher.none.fl_str_mv |
Centro Hospitalar Universitário de Santo António |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133559957487616 |