Petechiae in the newborn: A sign to consider
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200147 |
Resumo: | Abstract Neonatal alloimmune thrombocytopenia (NAIT) occurs when the mother develops antiplatelet antibodies against fetal platelets and is confirmed by the presence of maternal antihuman platelet antibodies. A full-term newborn from a first pregnancy without complications was routinely examined on the first day of life. The newborn appeared well and had multiple petechiae on the axillary, inguinal, and popliteal folds and on the lower abdomen, with no other findings. Blood work revealed thrombocytopenia of 28,000/ul with a normal remaining hemogram and negative C-reactive protein. Because of the suspicion of NAIT, an intravenous dose of immunoglobulin was administered with a subsequent increase in platelet count. The diagnosis was confirmed on day 5 with the detection of maternal antiplatelet anti-HPA-1a alloantibodies. A thorough physical examination of the newborn is essential, as some serious conditions may present with subtle changes. NAIT should be considered in the differential diagnosis of isolated petechiae of the newborn. |
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Petechiae in the newborn: A sign to consideralloimuneneonatalthrombocytopeniaAbstract Neonatal alloimmune thrombocytopenia (NAIT) occurs when the mother develops antiplatelet antibodies against fetal platelets and is confirmed by the presence of maternal antihuman platelet antibodies. A full-term newborn from a first pregnancy without complications was routinely examined on the first day of life. The newborn appeared well and had multiple petechiae on the axillary, inguinal, and popliteal folds and on the lower abdomen, with no other findings. Blood work revealed thrombocytopenia of 28,000/ul with a normal remaining hemogram and negative C-reactive protein. Because of the suspicion of NAIT, an intravenous dose of immunoglobulin was administered with a subsequent increase in platelet count. The diagnosis was confirmed on day 5 with the detection of maternal antiplatelet anti-HPA-1a alloantibodies. A thorough physical examination of the newborn is essential, as some serious conditions may present with subtle changes. NAIT should be considered in the differential diagnosis of isolated petechiae of the newborn.Centro Hospitalar do Porto2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200147Nascer e Crescer v.32 n.2 2023reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200147Gaia,MariaSilva,Joana BrandãoCapela,MarianaPinto,Ruiinfo:eu-repo/semantics/openAccess2024-02-06T17:06:38Zoai:scielo:S0872-07542023000200147Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:54.761225Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Petechiae in the newborn: A sign to consider |
title |
Petechiae in the newborn: A sign to consider |
spellingShingle |
Petechiae in the newborn: A sign to consider Gaia,Maria alloimune neonatal thrombocytopenia |
title_short |
Petechiae in the newborn: A sign to consider |
title_full |
Petechiae in the newborn: A sign to consider |
title_fullStr |
Petechiae in the newborn: A sign to consider |
title_full_unstemmed |
Petechiae in the newborn: A sign to consider |
title_sort |
Petechiae in the newborn: A sign to consider |
author |
Gaia,Maria |
author_facet |
Gaia,Maria Silva,Joana Brandão Capela,Mariana Pinto,Rui |
author_role |
author |
author2 |
Silva,Joana Brandão Capela,Mariana Pinto,Rui |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gaia,Maria Silva,Joana Brandão Capela,Mariana Pinto,Rui |
dc.subject.por.fl_str_mv |
alloimune neonatal thrombocytopenia |
topic |
alloimune neonatal thrombocytopenia |
description |
Abstract Neonatal alloimmune thrombocytopenia (NAIT) occurs when the mother develops antiplatelet antibodies against fetal platelets and is confirmed by the presence of maternal antihuman platelet antibodies. A full-term newborn from a first pregnancy without complications was routinely examined on the first day of life. The newborn appeared well and had multiple petechiae on the axillary, inguinal, and popliteal folds and on the lower abdomen, with no other findings. Blood work revealed thrombocytopenia of 28,000/ul with a normal remaining hemogram and negative C-reactive protein. Because of the suspicion of NAIT, an intravenous dose of immunoglobulin was administered with a subsequent increase in platelet count. The diagnosis was confirmed on day 5 with the detection of maternal antiplatelet anti-HPA-1a alloantibodies. A thorough physical examination of the newborn is essential, as some serious conditions may present with subtle changes. NAIT should be considered in the differential diagnosis of isolated petechiae of the newborn. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200147 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200147 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200147 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro Hospitalar do Porto |
publisher.none.fl_str_mv |
Centro Hospitalar do Porto |
dc.source.none.fl_str_mv |
Nascer e Crescer v.32 n.2 2023 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137288861515776 |