Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase

Detalhes bibliográficos
Autor(a) principal: Oliveira, Paulo
Data de Publicação: 2001
Outros Autores: Rolo, Anabela, Palmeira, Carlos, Moreno, António
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/7829
https://doi.org/10.1385/CT:1:3:205
Resumo: Abstract The cardioprotective properties of new pharmaceuticals such as carvedilol might be explained by enhanced mitochondrial protection. The aim of this work was to determine the role of carvedilol in the protection of heart mitochondria from oxidative damage induced by hypoxanthine/xanthine oxidase, a known source of oxidative stress in the vascular system. Carvedilol reduced oxidative-stress-induced mitochondrial injury, as seen by the delay in the loss of the mitochondrial transmembranar potential (??), the decrease in mitochondrial swelling, and the increase in mitochondrial calcium uptake. Carvedilol improved the mitochondrial respiratory activity in state III and offered an overall protection in the respiratory control and in the P/O ratios in mitochondria under oxidative stress. The data indicated that carvedilol was able to partly protect heart mitochondria from oxidative stress-induced damage. Our results suggest that mitochondria can be important targets for some cardioprotective pharmaceuticals.
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spelling Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidaseAbstract The cardioprotective properties of new pharmaceuticals such as carvedilol might be explained by enhanced mitochondrial protection. The aim of this work was to determine the role of carvedilol in the protection of heart mitochondria from oxidative damage induced by hypoxanthine/xanthine oxidase, a known source of oxidative stress in the vascular system. Carvedilol reduced oxidative-stress-induced mitochondrial injury, as seen by the delay in the loss of the mitochondrial transmembranar potential (??), the decrease in mitochondrial swelling, and the increase in mitochondrial calcium uptake. Carvedilol improved the mitochondrial respiratory activity in state III and offered an overall protection in the respiratory control and in the P/O ratios in mitochondria under oxidative stress. The data indicated that carvedilol was able to partly protect heart mitochondria from oxidative stress-induced damage. Our results suggest that mitochondria can be important targets for some cardioprotective pharmaceuticals.2001info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/7829http://hdl.handle.net/10316/7829https://doi.org/10.1385/CT:1:3:205engCardiovascular Toxicology. 1:3 (2001) 205-213Oliveira, PauloRolo, AnabelaPalmeira, CarlosMoreno, Antónioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-20T14:00:38Zoai:estudogeral.uc.pt:10316/7829Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:33.794653Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
title Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
spellingShingle Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
Oliveira, Paulo
title_short Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
title_full Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
title_fullStr Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
title_full_unstemmed Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
title_sort Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
author Oliveira, Paulo
author_facet Oliveira, Paulo
Rolo, Anabela
Palmeira, Carlos
Moreno, António
author_role author
author2 Rolo, Anabela
Palmeira, Carlos
Moreno, António
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira, Paulo
Rolo, Anabela
Palmeira, Carlos
Moreno, António
description Abstract The cardioprotective properties of new pharmaceuticals such as carvedilol might be explained by enhanced mitochondrial protection. The aim of this work was to determine the role of carvedilol in the protection of heart mitochondria from oxidative damage induced by hypoxanthine/xanthine oxidase, a known source of oxidative stress in the vascular system. Carvedilol reduced oxidative-stress-induced mitochondrial injury, as seen by the delay in the loss of the mitochondrial transmembranar potential (??), the decrease in mitochondrial swelling, and the increase in mitochondrial calcium uptake. Carvedilol improved the mitochondrial respiratory activity in state III and offered an overall protection in the respiratory control and in the P/O ratios in mitochondria under oxidative stress. The data indicated that carvedilol was able to partly protect heart mitochondria from oxidative stress-induced damage. Our results suggest that mitochondria can be important targets for some cardioprotective pharmaceuticals.
publishDate 2001
dc.date.none.fl_str_mv 2001
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/7829
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https://doi.org/10.1385/CT:1:3:205
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dc.relation.none.fl_str_mv Cardiovascular Toxicology. 1:3 (2001) 205-213
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