Functional and molecular characterization of cancer stem-like cells in bladder cancer

Detalhes bibliográficos
Autor(a) principal: Ferreira-Teixeira, Margarida
Data de Publicação: 2015
Outros Autores: Parada, Belmiro, Rodrigues-Santos, Paulo, Alves, Vera, Ramalho, José S., Caramelo, Francisco, Sousa, Vitor, Reis, Flávio, Gomes, Célia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/149786
Resumo: Funding: This work was supported by the Astellas European Foundation Uro-Oncology Grant 2014; JABA RECORDATI Urology 2011 - Portuguese Society of Urology; Portuguese Foundation for Science and Technology (Strategic Project: PEst-C/SAU/UI3282/2013 and UID/NEU/04539/2013); GAI/FMUC and Santander Totta (Ref. FreitasGomes04.01.13) and Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Portugal (Ref. 14/12). Margarida FerreiraTeixeira benefits from a PhD scholarship from the Portuguese Foundation for Science and Technology (Reference SFRH/BD/77314/2011).
id RCAP_ef67ff4b2c620c29d053fa7a144c4fad
oai_identifier_str oai:run.unl.pt:10362/149786
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Functional and molecular characterization of cancer stem-like cells in bladder cancerA potential signature for muscle-invasive tumorsALDHBladder cancerCancer stem cellsChemoresistanceStemness markersOncologySDG 3 - Good Health and Well-beingFunding: This work was supported by the Astellas European Foundation Uro-Oncology Grant 2014; JABA RECORDATI Urology 2011 - Portuguese Society of Urology; Portuguese Foundation for Science and Technology (Strategic Project: PEst-C/SAU/UI3282/2013 and UID/NEU/04539/2013); GAI/FMUC and Santander Totta (Ref. FreitasGomes04.01.13) and Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Portugal (Ref. 14/12). Margarida FerreiraTeixeira benefits from a PhD scholarship from the Portuguese Foundation for Science and Technology (Reference SFRH/BD/77314/2011).Striking evidence associates cancer stem cells (CSCs) to the high recurrence rates and poor survival of patients with muscle-invasive bladder cancer (BC). However, the prognostic implication of those cells in risk stratification is not firmly established, mainly due to the functional and phenotypic heterogeneity of CSCs populations, as well as, to the conflicting data regarding their identification based on a single specific marker. This emphasizes the need to exploit putative CSC-related molecular markers with potential prognostic significance in BC patients. This study aimed to isolate and characterize bladder CSCs making use of different functional and molecular approaches. The data obtained provide strong evidence that muscle-invasive BC is enriched with a heterogeneous stem-like population characterized by enhanced chemoresistance and tumor initiating properties, able to recapitulate the heterogeneity of the original tumor. Additionally, a logistic regression analysis identified a 2-gene stem-like signature (SOX2 and ALDH2) that allows a 93% accurate discrimination between non-muscle-invasive and invasive tumors. Our findings suggest that a stemness-related gene signature, combined with a cluster of markers to more narrowly refine the CSC phenotype, could better identify BC patients that would benefit from a more aggressive therapeutic intervention targeting CSCs population.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFerreira-Teixeira, MargaridaParada, BelmiroRodrigues-Santos, PauloAlves, VeraRamalho, José S.Caramelo, FranciscoSousa, VitorReis, FlávioGomes, Célia M.2023-02-27T22:21:36Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/149786eng1949-2553PURE: 47547878https://doi.org/10.18632/oncotarget.5517info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:09:32Zoai:run.unl.pt:10362/149786Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:09:32Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functional and molecular characterization of cancer stem-like cells in bladder cancer
A potential signature for muscle-invasive tumors
title Functional and molecular characterization of cancer stem-like cells in bladder cancer
spellingShingle Functional and molecular characterization of cancer stem-like cells in bladder cancer
Ferreira-Teixeira, Margarida
ALDH
Bladder cancer
Cancer stem cells
Chemoresistance
Stemness markers
Oncology
SDG 3 - Good Health and Well-being
title_short Functional and molecular characterization of cancer stem-like cells in bladder cancer
title_full Functional and molecular characterization of cancer stem-like cells in bladder cancer
title_fullStr Functional and molecular characterization of cancer stem-like cells in bladder cancer
title_full_unstemmed Functional and molecular characterization of cancer stem-like cells in bladder cancer
title_sort Functional and molecular characterization of cancer stem-like cells in bladder cancer
author Ferreira-Teixeira, Margarida
author_facet Ferreira-Teixeira, Margarida
Parada, Belmiro
Rodrigues-Santos, Paulo
Alves, Vera
Ramalho, José S.
Caramelo, Francisco
Sousa, Vitor
Reis, Flávio
Gomes, Célia M.
author_role author
author2 Parada, Belmiro
Rodrigues-Santos, Paulo
Alves, Vera
Ramalho, José S.
Caramelo, Francisco
Sousa, Vitor
Reis, Flávio
Gomes, Célia M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Ferreira-Teixeira, Margarida
Parada, Belmiro
Rodrigues-Santos, Paulo
Alves, Vera
Ramalho, José S.
Caramelo, Francisco
Sousa, Vitor
Reis, Flávio
Gomes, Célia M.
dc.subject.por.fl_str_mv ALDH
Bladder cancer
Cancer stem cells
Chemoresistance
Stemness markers
Oncology
SDG 3 - Good Health and Well-being
topic ALDH
Bladder cancer
Cancer stem cells
Chemoresistance
Stemness markers
Oncology
SDG 3 - Good Health and Well-being
description Funding: This work was supported by the Astellas European Foundation Uro-Oncology Grant 2014; JABA RECORDATI Urology 2011 - Portuguese Society of Urology; Portuguese Foundation for Science and Technology (Strategic Project: PEst-C/SAU/UI3282/2013 and UID/NEU/04539/2013); GAI/FMUC and Santander Totta (Ref. FreitasGomes04.01.13) and Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Portugal (Ref. 14/12). Margarida FerreiraTeixeira benefits from a PhD scholarship from the Portuguese Foundation for Science and Technology (Reference SFRH/BD/77314/2011).
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2023-02-27T22:21:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/149786
url http://hdl.handle.net/10362/149786
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1949-2553
PURE: 47547878
https://doi.org/10.18632/oncotarget.5517
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817545919326846976

Registros relacionados