HLA-B27 polymorphism and spondyloarthropathies.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1031 |
Resumo: | The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS. |
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HLA-B27 polymorphism and spondyloarthropathies.Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias.The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS.The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS.Ordem dos Médicos2005-08-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1031oai:ojs.www.actamedicaportuguesa.com:article/1031Acta Médica Portuguesa; Vol. 18 No. 4 (2005): July-August; 283-93Acta Médica Portuguesa; Vol. 18 N.º 4 (2005): Julho-Agosto; 283-931646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1031https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1031/699Peixoto, M JGonzales, TSpinola, HCouto, A RMora, M GantesBrehm, ASantos, M RGarrett, FArmas, J Brugesinfo:eu-repo/semantics/openAccess2022-12-20T10:57:21Zoai:ojs.www.actamedicaportuguesa.com:article/1031Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:55.416974Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
HLA-B27 polymorphism and spondyloarthropathies. Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias. |
| title |
HLA-B27 polymorphism and spondyloarthropathies. |
| spellingShingle |
HLA-B27 polymorphism and spondyloarthropathies. Peixoto, M J |
| title_short |
HLA-B27 polymorphism and spondyloarthropathies. |
| title_full |
HLA-B27 polymorphism and spondyloarthropathies. |
| title_fullStr |
HLA-B27 polymorphism and spondyloarthropathies. |
| title_full_unstemmed |
HLA-B27 polymorphism and spondyloarthropathies. |
| title_sort |
HLA-B27 polymorphism and spondyloarthropathies. |
| author |
Peixoto, M J |
| author_facet |
Peixoto, M J Gonzales, T Spinola, H Couto, A R Mora, M Gantes Brehm, A Santos, M R Garrett, F Armas, J Bruges |
| author_role |
author |
| author2 |
Gonzales, T Spinola, H Couto, A R Mora, M Gantes Brehm, A Santos, M R Garrett, F Armas, J Bruges |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Peixoto, M J Gonzales, T Spinola, H Couto, A R Mora, M Gantes Brehm, A Santos, M R Garrett, F Armas, J Bruges |
| description |
The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS. |
| publishDate |
2005 |
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2005-08-31 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1031 oai:ojs.www.actamedicaportuguesa.com:article/1031 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1031 |
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oai:ojs.www.actamedicaportuguesa.com:article/1031 |
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por |
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por |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1031 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1031/699 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 18 No. 4 (2005): July-August; 283-93 Acta Médica Portuguesa; Vol. 18 N.º 4 (2005): Julho-Agosto; 283-93 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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