Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/80329 |
Resumo: | Osteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month-old rats were randomly allocated to: (1) placebo-control, (2) ALE group (7.5 μg/kg of body weight/day/5 times per week), (3) VD/Ca group (VD: 35 μg/kg of body weight/day/5 times per week; Ca: 13 mg/kg of body weight/day/3 times per week), and (4) BC supplementation (OVX: 1.5 g/day/5 times per week; ORX: 2 g/day/5 times per week). Following four months of supplementation, bone microarchitecture, strength and bone markers were evaluated. ALE group demonstrated significantly higher Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC and significantly lower Ct.Pr, Tb.Pr, Tb.Sp, Ct.BMD and Tb.BMD, compared to placebo (<i>p</i> < 0.05). BC presented significantly higher Ct.Pr, Ct.BMD, Tb.Pr, Tb.Sp, and Tb.BMD and significantly lower Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC compared to ALE in OVX rats (<i>p</i> < 0.05). OVX rats receiving BC experienced a significant increase in serum ALP and OC levels post-supplementation (<i>p</i> < 0.05). BC supplementation may induce positive effects on bone metabolism by stimulating bone formation, but appear not to be as effective as ALE. |
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Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat modelosteoporosisalessndronatevitamin Dcalciumbovine colostrumCiências Médicas::Medicina BásicaScience & TechnologyOsteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month-old rats were randomly allocated to: (1) placebo-control, (2) ALE group (7.5 μg/kg of body weight/day/5 times per week), (3) VD/Ca group (VD: 35 μg/kg of body weight/day/5 times per week; Ca: 13 mg/kg of body weight/day/3 times per week), and (4) BC supplementation (OVX: 1.5 g/day/5 times per week; ORX: 2 g/day/5 times per week). Following four months of supplementation, bone microarchitecture, strength and bone markers were evaluated. ALE group demonstrated significantly higher Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC and significantly lower Ct.Pr, Tb.Pr, Tb.Sp, Ct.BMD and Tb.BMD, compared to placebo (<i>p</i> < 0.05). BC presented significantly higher Ct.Pr, Ct.BMD, Tb.Pr, Tb.Sp, and Tb.BMD and significantly lower Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC compared to ALE in OVX rats (<i>p</i> < 0.05). OVX rats receiving BC experienced a significant increase in serum ALP and OC levels post-supplementation (<i>p</i> < 0.05). BC supplementation may induce positive effects on bone metabolism by stimulating bone formation, but appear not to be as effective as ALE.MSCA-RISE—Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) grant funded by the European Union (Grant agreement number: 778277).Multidisciplinary Digital Publishing InstituteUniversidade do MinhoKydonaki, Eirini K.Freitas, LauraReguengo, HenriqueSimón, Carlos RaposoBastos, Ana Raquel FernandesFernandes, Emanuel MoutaCanadas, Raphaël F.Oliveira, Joaquim M.Correlo, V. M.Reis, R. L.Vliora, MariaGkiata, ParaskeviKoutedakis, YiannisNtina, GeorgiaPinto, RuiCarrillo, Andres E.Marques, FranklimAmorim, Tânia2022-07-112022-07-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/80329engKydonaki, E.K.; Freitas, L.; Reguengo, H.; Simón, C.R.; Bastos, A.R.; Fernandes, E.M.; Canadas, R.F.; Oliveira, J.M.; Correlo, V.M.; Reis, R.L.; Vliora, M.; Gkiata, P.; Koutedakis, Y.; Ntina, G.; Pinto, R.; Carrillo, A.E.; Marques, F.; Amorim, T. Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model. Nutrients 2022, 14, 2837. https://doi.org/10.3390/nu141428372072-664310.3390/nu1414283735889794https://www.mdpi.com/2072-6643/14/14/2837info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:02Zoai:repositorium.sdum.uminho.pt:1822/80329Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:03.684399Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model |
title |
Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model |
spellingShingle |
Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model Kydonaki, Eirini K. osteoporosis alessndronate vitamin D calcium bovine colostrum Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model |
title_full |
Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model |
title_fullStr |
Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model |
title_full_unstemmed |
Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model |
title_sort |
Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model |
author |
Kydonaki, Eirini K. |
author_facet |
Kydonaki, Eirini K. Freitas, Laura Reguengo, Henrique Simón, Carlos Raposo Bastos, Ana Raquel Fernandes Fernandes, Emanuel Mouta Canadas, Raphaël F. Oliveira, Joaquim M. Correlo, V. M. Reis, R. L. Vliora, Maria Gkiata, Paraskevi Koutedakis, Yiannis Ntina, Georgia Pinto, Rui Carrillo, Andres E. Marques, Franklim Amorim, Tânia |
author_role |
author |
author2 |
Freitas, Laura Reguengo, Henrique Simón, Carlos Raposo Bastos, Ana Raquel Fernandes Fernandes, Emanuel Mouta Canadas, Raphaël F. Oliveira, Joaquim M. Correlo, V. M. Reis, R. L. Vliora, Maria Gkiata, Paraskevi Koutedakis, Yiannis Ntina, Georgia Pinto, Rui Carrillo, Andres E. Marques, Franklim Amorim, Tânia |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Kydonaki, Eirini K. Freitas, Laura Reguengo, Henrique Simón, Carlos Raposo Bastos, Ana Raquel Fernandes Fernandes, Emanuel Mouta Canadas, Raphaël F. Oliveira, Joaquim M. Correlo, V. M. Reis, R. L. Vliora, Maria Gkiata, Paraskevi Koutedakis, Yiannis Ntina, Georgia Pinto, Rui Carrillo, Andres E. Marques, Franklim Amorim, Tânia |
dc.subject.por.fl_str_mv |
osteoporosis alessndronate vitamin D calcium bovine colostrum Ciências Médicas::Medicina Básica Science & Technology |
topic |
osteoporosis alessndronate vitamin D calcium bovine colostrum Ciências Médicas::Medicina Básica Science & Technology |
description |
Osteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month-old rats were randomly allocated to: (1) placebo-control, (2) ALE group (7.5 μg/kg of body weight/day/5 times per week), (3) VD/Ca group (VD: 35 μg/kg of body weight/day/5 times per week; Ca: 13 mg/kg of body weight/day/3 times per week), and (4) BC supplementation (OVX: 1.5 g/day/5 times per week; ORX: 2 g/day/5 times per week). Following four months of supplementation, bone microarchitecture, strength and bone markers were evaluated. ALE group demonstrated significantly higher Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC and significantly lower Ct.Pr, Tb.Pr, Tb.Sp, Ct.BMD and Tb.BMD, compared to placebo (<i>p</i> < 0.05). BC presented significantly higher Ct.Pr, Ct.BMD, Tb.Pr, Tb.Sp, and Tb.BMD and significantly lower Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC compared to ALE in OVX rats (<i>p</i> < 0.05). OVX rats receiving BC experienced a significant increase in serum ALP and OC levels post-supplementation (<i>p</i> < 0.05). BC supplementation may induce positive effects on bone metabolism by stimulating bone formation, but appear not to be as effective as ALE. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-11 2022-07-11T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/80329 |
url |
https://hdl.handle.net/1822/80329 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Kydonaki, E.K.; Freitas, L.; Reguengo, H.; Simón, C.R.; Bastos, A.R.; Fernandes, E.M.; Canadas, R.F.; Oliveira, J.M.; Correlo, V.M.; Reis, R.L.; Vliora, M.; Gkiata, P.; Koutedakis, Y.; Ntina, G.; Pinto, R.; Carrillo, A.E.; Marques, F.; Amorim, T. Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model. Nutrients 2022, 14, 2837. https://doi.org/10.3390/nu14142837 2072-6643 10.3390/nu14142837 35889794 https://www.mdpi.com/2072-6643/14/14/2837 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132461785939968 |