Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort

Detalhes bibliográficos
Autor(a) principal: Carvalho, Pedro D.
Data de Publicação: 2020
Outros Autores: Ruyssen-Witrand, Adeline, Fonseca, João Eurico, Marreiros, Ana, Machado, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46630
Resumo: Copyright information: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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spelling Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohortAnkylosingMRIPatient reported outcome measuresSpondylitisCopyright information: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Objective: To investigate the determinants of impaired spinal and hip mobility in patients with early axial spondyloarthritis (axSpA). Methods: Five-year longitudinal data from the DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR) cohort were analysed. Associations were investigated using generalised estimating equations, using Bath Ankylosing Spondylitis Metrology Index (BASMI) linear or each of the five components of BASMI as dependent variables, and clinical and demographic variables as independent variables in univariable models. Multivariable analyses were performed, adjusting for potential confounders. Results: Data from 644 patients and 5152 visits were analysed. Higher BASMI values were independently and positively associated with Ankylosing Spondylitis Disease Activity Score C reactive protein (ASDAS-CRP) (adjusted B (adjB)=0.21; 95% CI=0.15 to 0.28), MRI spinal inflammation score (adjB=0.11; 95% CI=0.04 to 0.19), enthesitis score (adjB=0.02; 95% CI=0.01 to 0.04) and age (adjB=0.02; 95% CI=0.01 to 0.03). All BASMI components were independently associated with ASDAS-CRP and MRI spinal inflammation, except for maximal intermalleolar distance (reflecting hip mobility), which was not associated with MRI spinal inflammation. Conclusion: In early axSpA, spinal mobility impairment is independently determined by clinical disease activity, MRI spinal inflammation, enthesitis and age. The influence of spinal inflammation prevails in early axSpA, as opposed to spinal structural damage, which may become more relevant in later disease stages.BMJ Publishing Group Ltd.Repositório da Universidade de LisboaCarvalho, Pedro D.Ruyssen-Witrand, AdelineFonseca, João EuricoMarreiros, AnaMachado, Pedro2021-03-03T17:33:17Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46630engRMD Open. 2020 Oct;6(3):e00135610.1136/rmdopen-2020-0013562056-5933info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:02Zoai:repositorio.ul.pt:10451/46630Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:46.372027Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort
title Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort
spellingShingle Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort
Carvalho, Pedro D.
Ankylosing
MRI
Patient reported outcome measures
Spondylitis
title_short Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort
title_full Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort
title_fullStr Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort
title_full_unstemmed Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort
title_sort Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis : longitudinal results from the DESIR cohort
author Carvalho, Pedro D.
author_facet Carvalho, Pedro D.
Ruyssen-Witrand, Adeline
Fonseca, João Eurico
Marreiros, Ana
Machado, Pedro
author_role author
author2 Ruyssen-Witrand, Adeline
Fonseca, João Eurico
Marreiros, Ana
Machado, Pedro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Carvalho, Pedro D.
Ruyssen-Witrand, Adeline
Fonseca, João Eurico
Marreiros, Ana
Machado, Pedro
dc.subject.por.fl_str_mv Ankylosing
MRI
Patient reported outcome measures
Spondylitis
topic Ankylosing
MRI
Patient reported outcome measures
Spondylitis
description Copyright information: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-03-03T17:33:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46630
url http://hdl.handle.net/10451/46630
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv RMD Open. 2020 Oct;6(3):e001356
10.1136/rmdopen-2020-001356
2056-5933
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group Ltd.
publisher.none.fl_str_mv BMJ Publishing Group Ltd.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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