Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions

Detalhes bibliográficos
Autor(a) principal: Gómez-González, Borja
Data de Publicação: 2022
Outros Autores: García-Río, Luis, Basílio, Nuno, Mejuto, Juan C., Simal-Gandara, Jesus
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/134249
Resumo: CTQ2017-84354-P (GR 2007/085ED431C2018/42-GRC)
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spelling Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic InteractionsHost:guestHydrophobicITCNMRPillarareneSupramolecularPharmaceutical ScienceCTQ2017-84354-P (GR 2007/085ED431C2018/42-GRC)The formation of inclusion complexes between alkylsulfonate guests and a cationic pil-lar[5]arene receptor in water was investigated by NMR and ITC techniques. The results show the formation of host-guest complexes stabilized by electrostatic interactions and hydrophobic effects with binding constants of up to 107 M−1 for the guest with higher hydrophobic character. Structurally, the alkyl chain of the guest is included in the hydrophobic aromatic cavity of the macrocycle while the sulfonate groups are held in the multicationic portal by ionic interactions.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNGómez-González, BorjaGarcía-Río, LuisBasílio, NunoMejuto, Juan C.Simal-Gandara, Jesus2022-03-10T23:23:22Z2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/134249eng1999-4923PURE: 36201186https://doi.org/10.3390/pharmaceutics14010060info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:00:03Zoai:run.unl.pt:10362/134249Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:00:03Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
title Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
spellingShingle Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
Gómez-González, Borja
Host:guest
Hydrophobic
ITC
NMR
Pillararene
Supramolecular
Pharmaceutical Science
title_short Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
title_full Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
title_fullStr Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
title_full_unstemmed Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
title_sort Molecular Recognition by Pillar[5]arenes Evidence for Simultaneous Electrostatic and Hydrophobic Interactions
author Gómez-González, Borja
author_facet Gómez-González, Borja
García-Río, Luis
Basílio, Nuno
Mejuto, Juan C.
Simal-Gandara, Jesus
author_role author
author2 García-Río, Luis
Basílio, Nuno
Mejuto, Juan C.
Simal-Gandara, Jesus
author2_role author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Gómez-González, Borja
García-Río, Luis
Basílio, Nuno
Mejuto, Juan C.
Simal-Gandara, Jesus
dc.subject.por.fl_str_mv Host:guest
Hydrophobic
ITC
NMR
Pillararene
Supramolecular
Pharmaceutical Science
topic Host:guest
Hydrophobic
ITC
NMR
Pillararene
Supramolecular
Pharmaceutical Science
description CTQ2017-84354-P (GR 2007/085ED431C2018/42-GRC)
publishDate 2022
dc.date.none.fl_str_mv 2022-03-10T23:23:22Z
2022-01
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/134249
url http://hdl.handle.net/10362/134249
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
PURE: 36201186
https://doi.org/10.3390/pharmaceutics14010060
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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