Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/91201 https://doi.org/10.1016/j.jri.2020.103215 |
Resumo: | Background: During pregnancy, the maternal immune system must create and sustain tolerance to the allogeneic fetus while maintaining the ability to protect against microbial assaults. Objectives: Ascertain the immunological differences in immune cells of pregnant women that may influence SARS-CoV-2 infection. Study design: Systematic review conducted in accordance with PRISMA guidelines and registered within PROSPERO CRD42020189735. A systematic search was undertaken across ISI, PubMed, Scopus, Embase, Cochrane Library and clinical trials.gov from January 2019 up until June 2020. Eligibility criteria included COVID-19 infection, pregnancy, and availability of immune characteristics for the pregnant women. Two authors independently screened for the suitability of inclusion. Main outcome measures: Information was manually extracted from full-text articles and efforts were made to identify overlapping data. Variables extracted and analysed included the quantification of white blood cells (WBC), lymphocytes, and C-reactive protein (CRP). Results: The literature search yielded 162 studies, of which 11 were considered appropriate for selection. Only four were used in this systematic review. Our research showed that pregnant women with COVID-19 only differ from other pregnant women in their lower WBC count. The proportion of reduced lymphocyte cases is similar in both groups, as is the case of Creactive protein levels. Conclusions: In line with previous coronavirus infections, severe maternal morbidity and perinatal death with COVID-19 infection were more likely to be expected in pregnancy. Our research showed that pregnant women with COVID-19 in terms of immunity only differ from other pregnant women in their lower WBC count. |
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Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic reviewGravidez/PregnancyCOVID-19SARS-CoV-2Imunidade/ImmunityBackground: During pregnancy, the maternal immune system must create and sustain tolerance to the allogeneic fetus while maintaining the ability to protect against microbial assaults. Objectives: Ascertain the immunological differences in immune cells of pregnant women that may influence SARS-CoV-2 infection. Study design: Systematic review conducted in accordance with PRISMA guidelines and registered within PROSPERO CRD42020189735. A systematic search was undertaken across ISI, PubMed, Scopus, Embase, Cochrane Library and clinical trials.gov from January 2019 up until June 2020. Eligibility criteria included COVID-19 infection, pregnancy, and availability of immune characteristics for the pregnant women. Two authors independently screened for the suitability of inclusion. Main outcome measures: Information was manually extracted from full-text articles and efforts were made to identify overlapping data. Variables extracted and analysed included the quantification of white blood cells (WBC), lymphocytes, and C-reactive protein (CRP). Results: The literature search yielded 162 studies, of which 11 were considered appropriate for selection. Only four were used in this systematic review. Our research showed that pregnant women with COVID-19 only differ from other pregnant women in their lower WBC count. The proportion of reduced lymphocyte cases is similar in both groups, as is the case of Creactive protein levels. Conclusions: In line with previous coronavirus infections, severe maternal morbidity and perinatal death with COVID-19 infection were more likely to be expected in pregnancy. Our research showed that pregnant women with COVID-19 in terms of immunity only differ from other pregnant women in their lower WBC count.Elsevier2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/91201http://hdl.handle.net/10316/91201https://doi.org/10.1016/j.jri.2020.103215por01650378https://www.sciencedirect.com/science/article/pii/S0165037820301364?dgcid=coauthorAreia, Ana Luísa Fialho Amaral dePinto, Anabela Motainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T06:14:49Zoai:estudogeral.uc.pt:10316/91201Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:11:07.936920Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review |
title |
Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review |
spellingShingle |
Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review Areia, Ana Luísa Fialho Amaral de Gravidez/Pregnancy COVID-19 SARS-CoV-2 Imunidade/Immunity |
title_short |
Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review |
title_full |
Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review |
title_fullStr |
Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review |
title_full_unstemmed |
Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review |
title_sort |
Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review |
author |
Areia, Ana Luísa Fialho Amaral de |
author_facet |
Areia, Ana Luísa Fialho Amaral de Pinto, Anabela Mota |
author_role |
author |
author2 |
Pinto, Anabela Mota |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Areia, Ana Luísa Fialho Amaral de Pinto, Anabela Mota |
dc.subject.por.fl_str_mv |
Gravidez/Pregnancy COVID-19 SARS-CoV-2 Imunidade/Immunity |
topic |
Gravidez/Pregnancy COVID-19 SARS-CoV-2 Imunidade/Immunity |
description |
Background: During pregnancy, the maternal immune system must create and sustain tolerance to the allogeneic fetus while maintaining the ability to protect against microbial assaults. Objectives: Ascertain the immunological differences in immune cells of pregnant women that may influence SARS-CoV-2 infection. Study design: Systematic review conducted in accordance with PRISMA guidelines and registered within PROSPERO CRD42020189735. A systematic search was undertaken across ISI, PubMed, Scopus, Embase, Cochrane Library and clinical trials.gov from January 2019 up until June 2020. Eligibility criteria included COVID-19 infection, pregnancy, and availability of immune characteristics for the pregnant women. Two authors independently screened for the suitability of inclusion. Main outcome measures: Information was manually extracted from full-text articles and efforts were made to identify overlapping data. Variables extracted and analysed included the quantification of white blood cells (WBC), lymphocytes, and C-reactive protein (CRP). Results: The literature search yielded 162 studies, of which 11 were considered appropriate for selection. Only four were used in this systematic review. Our research showed that pregnant women with COVID-19 only differ from other pregnant women in their lower WBC count. The proportion of reduced lymphocyte cases is similar in both groups, as is the case of Creactive protein levels. Conclusions: In line with previous coronavirus infections, severe maternal morbidity and perinatal death with COVID-19 infection were more likely to be expected in pregnancy. Our research showed that pregnant women with COVID-19 in terms of immunity only differ from other pregnant women in their lower WBC count. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/91201 http://hdl.handle.net/10316/91201 https://doi.org/10.1016/j.jri.2020.103215 |
url |
http://hdl.handle.net/10316/91201 https://doi.org/10.1016/j.jri.2020.103215 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
01650378 https://www.sciencedirect.com/science/article/pii/S0165037820301364?dgcid=coauthor |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134008246796288 |