Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/19891 |
Resumo: | Montelukast sodium is a leukotriene antagonist of growing interest as an alternative therapy for asthma across different age groups due to its bronchoprotective, anti-inflammatory and anti-allergic properties. Currently, montelukast is commercialized only in oral solid dosage forms, which are the favorite of adult patients but may pose challenges in administration to children of young age or patients suffering from dysphagia. This review presents a comprehensive revision of scientific reports and patents on emerging strategies for the delivery of montelukast. A common ground to these reports is the pursue of an enhanced montelukast performance, by increasing its bioavailability and physico-chemical stability. A wide variety of strategies can be found, from the formation of supramolecular adducts with cyclodextrins to encapsulation in nanoparticles and liposomes. The new dosage forms for montelukast are designed for non-enteric absorption, some for absorption in the oral cavity and another two being for local action in the nasal mucosa or in the pulmonary epithelium. The review describes the emerging delivery strategies to circumvent the current limitations to the use of montelukast that are expected to ultimately lead to the development of more patient-compliant dosage forms. |
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Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulationsLIPID NANOPARTICLES SLNEXERCISE-INDUCED BRONCHOCONSTRICTIONLEUKOTRIENE-RECEPTOR ANTAGONISTDRUG-DELIVERYCHITOSAN NANOPARTICLESCARRIERS NLCDOUBLE-BLINDIN-VITROASTHMASODIUMMontelukast sodium is a leukotriene antagonist of growing interest as an alternative therapy for asthma across different age groups due to its bronchoprotective, anti-inflammatory and anti-allergic properties. Currently, montelukast is commercialized only in oral solid dosage forms, which are the favorite of adult patients but may pose challenges in administration to children of young age or patients suffering from dysphagia. This review presents a comprehensive revision of scientific reports and patents on emerging strategies for the delivery of montelukast. A common ground to these reports is the pursue of an enhanced montelukast performance, by increasing its bioavailability and physico-chemical stability. A wide variety of strategies can be found, from the formation of supramolecular adducts with cyclodextrins to encapsulation in nanoparticles and liposomes. The new dosage forms for montelukast are designed for non-enteric absorption, some for absorption in the oral cavity and another two being for local action in the nasal mucosa or in the pulmonary epithelium. The review describes the emerging delivery strategies to circumvent the current limitations to the use of montelukast that are expected to ultimately lead to the development of more patient-compliant dosage forms.TAYLOR & FRANCIS LTD2017-12-07T19:28:22Z2016-01-01T00:00:00Z2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/19891eng1071-754410.3109/10717544.2016.1170247Barbosa, Jessica SilvaAlmeida Paz, Filipe A.Braga, Susana Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:38:48Zoai:ria.ua.pt:10773/19891Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:54:37.126310Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations |
title |
Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations |
spellingShingle |
Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations Barbosa, Jessica Silva LIPID NANOPARTICLES SLN EXERCISE-INDUCED BRONCHOCONSTRICTION LEUKOTRIENE-RECEPTOR ANTAGONIST DRUG-DELIVERY CHITOSAN NANOPARTICLES CARRIERS NLC DOUBLE-BLIND IN-VITRO ASTHMA SODIUM |
title_short |
Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations |
title_full |
Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations |
title_fullStr |
Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations |
title_full_unstemmed |
Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations |
title_sort |
Montelukast medicines of today and tomorrow: from molecular pharmaceutics to technological formulations |
author |
Barbosa, Jessica Silva |
author_facet |
Barbosa, Jessica Silva Almeida Paz, Filipe A. Braga, Susana Santos |
author_role |
author |
author2 |
Almeida Paz, Filipe A. Braga, Susana Santos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Barbosa, Jessica Silva Almeida Paz, Filipe A. Braga, Susana Santos |
dc.subject.por.fl_str_mv |
LIPID NANOPARTICLES SLN EXERCISE-INDUCED BRONCHOCONSTRICTION LEUKOTRIENE-RECEPTOR ANTAGONIST DRUG-DELIVERY CHITOSAN NANOPARTICLES CARRIERS NLC DOUBLE-BLIND IN-VITRO ASTHMA SODIUM |
topic |
LIPID NANOPARTICLES SLN EXERCISE-INDUCED BRONCHOCONSTRICTION LEUKOTRIENE-RECEPTOR ANTAGONIST DRUG-DELIVERY CHITOSAN NANOPARTICLES CARRIERS NLC DOUBLE-BLIND IN-VITRO ASTHMA SODIUM |
description |
Montelukast sodium is a leukotriene antagonist of growing interest as an alternative therapy for asthma across different age groups due to its bronchoprotective, anti-inflammatory and anti-allergic properties. Currently, montelukast is commercialized only in oral solid dosage forms, which are the favorite of adult patients but may pose challenges in administration to children of young age or patients suffering from dysphagia. This review presents a comprehensive revision of scientific reports and patents on emerging strategies for the delivery of montelukast. A common ground to these reports is the pursue of an enhanced montelukast performance, by increasing its bioavailability and physico-chemical stability. A wide variety of strategies can be found, from the formation of supramolecular adducts with cyclodextrins to encapsulation in nanoparticles and liposomes. The new dosage forms for montelukast are designed for non-enteric absorption, some for absorption in the oral cavity and another two being for local action in the nasal mucosa or in the pulmonary epithelium. The review describes the emerging delivery strategies to circumvent the current limitations to the use of montelukast that are expected to ultimately lead to the development of more patient-compliant dosage forms. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01T00:00:00Z 2016 2017-12-07T19:28:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/19891 |
url |
http://hdl.handle.net/10773/19891 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1071-7544 10.3109/10717544.2016.1170247 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
TAYLOR & FRANCIS LTD |
publisher.none.fl_str_mv |
TAYLOR & FRANCIS LTD |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137598658052096 |