Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children

Detalhes bibliográficos
Autor(a) principal: Gouveia, C
Data de Publicação: 2022
Outros Autores: Subtil, A, Norte, S, Arcangelo, J, Santos, MA, Corte-Real, R, Simões, MJ, Canhão, H, Tavares, D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/4214
Resumo: Background: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolution, were obtained. (3) Results: We found a total of 75 children, 44 with K. kingae and 31 with pyogenic infections (mostly MSSA, S. pneumoniae and S. pyogenes). K. kingae affected younger children with low or absent fever, low inflammatory markers and a favourable prognosis. In the univariate analyses, fever, septic look, CRP and ESR at admission and CRP at 48 h were significantly lower in K. kingae SA. In the multivariate analyses, age > 6 months ≤ 2 years, apyrexy and CRP ≤ 100 mg/L were significative, with an overall predictive positive value of 86.5%, and 88.4% for K. kingae. For this model, ROC curves were capable of differentiating (AUC 0.861, 95% CI 0.767-0.955) K. kingae SA from typical pathogens. (4) Conclusions: Age > 6 months ≤ 2 years, apyrexy and PCR ≤ 100 mg/L were the main predictive factors to distinguish K. kingae from pyogenic SA < 5 years. These data need to be validated in a larger study.
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spelling Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese ChildrenKingella kingaeSeptic arthritis/acutePyogenic infectionsHDE INF PEDHDE ORT PEDBackground: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolution, were obtained. (3) Results: We found a total of 75 children, 44 with K. kingae and 31 with pyogenic infections (mostly MSSA, S. pneumoniae and S. pyogenes). K. kingae affected younger children with low or absent fever, low inflammatory markers and a favourable prognosis. In the univariate analyses, fever, septic look, CRP and ESR at admission and CRP at 48 h were significantly lower in K. kingae SA. In the multivariate analyses, age > 6 months ≤ 2 years, apyrexy and CRP ≤ 100 mg/L were significative, with an overall predictive positive value of 86.5%, and 88.4% for K. kingae. For this model, ROC curves were capable of differentiating (AUC 0.861, 95% CI 0.767-0.955) K. kingae SA from typical pathogens. (4) Conclusions: Age > 6 months ≤ 2 years, apyrexy and PCR ≤ 100 mg/L were the main predictive factors to distinguish K. kingae from pyogenic SA < 5 years. These data need to be validated in a larger study.Multidisciplinary Digital Publishing Institute (MDPI)Repositório do Centro Hospitalar Universitário de Lisboa Central, EPEGouveia, CSubtil, ANorte, SArcangelo, JSantos, MACorte-Real, RSimões, MJCanhão, HTavares, D2022-08-17T14:55:26Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4214engMicroorganisms . 2022 Jun 16;10(6):123310.3390/microorganisms10061233info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:45:52Zoai:repositorio.chlc.min-saude.pt:10400.17/4214Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:32.533448Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
spellingShingle Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
Gouveia, C
Kingella kingae
Septic arthritis/acute
Pyogenic infections
HDE INF PED
HDE ORT PED
title_short Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title_full Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title_fullStr Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title_full_unstemmed Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title_sort Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
author Gouveia, C
author_facet Gouveia, C
Subtil, A
Norte, S
Arcangelo, J
Santos, MA
Corte-Real, R
Simões, MJ
Canhão, H
Tavares, D
author_role author
author2 Subtil, A
Norte, S
Arcangelo, J
Santos, MA
Corte-Real, R
Simões, MJ
Canhão, H
Tavares, D
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Gouveia, C
Subtil, A
Norte, S
Arcangelo, J
Santos, MA
Corte-Real, R
Simões, MJ
Canhão, H
Tavares, D
dc.subject.por.fl_str_mv Kingella kingae
Septic arthritis/acute
Pyogenic infections
HDE INF PED
HDE ORT PED
topic Kingella kingae
Septic arthritis/acute
Pyogenic infections
HDE INF PED
HDE ORT PED
description Background: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolution, were obtained. (3) Results: We found a total of 75 children, 44 with K. kingae and 31 with pyogenic infections (mostly MSSA, S. pneumoniae and S. pyogenes). K. kingae affected younger children with low or absent fever, low inflammatory markers and a favourable prognosis. In the univariate analyses, fever, septic look, CRP and ESR at admission and CRP at 48 h were significantly lower in K. kingae SA. In the multivariate analyses, age > 6 months ≤ 2 years, apyrexy and CRP ≤ 100 mg/L were significative, with an overall predictive positive value of 86.5%, and 88.4% for K. kingae. For this model, ROC curves were capable of differentiating (AUC 0.861, 95% CI 0.767-0.955) K. kingae SA from typical pathogens. (4) Conclusions: Age > 6 months ≤ 2 years, apyrexy and PCR ≤ 100 mg/L were the main predictive factors to distinguish K. kingae from pyogenic SA < 5 years. These data need to be validated in a larger study.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-17T14:55:26Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/4214
url http://hdl.handle.net/10400.17/4214
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microorganisms . 2022 Jun 16;10(6):1233
10.3390/microorganisms10061233
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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