Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children

Detalhes bibliográficos
Autor(a) principal: Gouveia, Catarina
Data de Publicação: 2022
Outros Autores: Subtil, Ana, Norte, Susana, Arcangelo, Joana, Santos, Madalena Almeida, Corte-Real, Rita, Simões, Maria João, Canhão, Helena, Tavares, Delfin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8538
Resumo: This article belongs to the Special Issue Kingella kingae: Virulence Factors, Clinical Disease, and Diagnostics.
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spelling Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese ChildrenKingella kingaeAcute Septic ArthritisPyogenic InfectionsDiagnosticsAcute Septic ArthritisChildrenPortugalInfecções RespiratóriasThis article belongs to the Special Issue Kingella kingae: Virulence Factors, Clinical Disease, and Diagnostics.(1) Background: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolution, were obtained. (3) Results: We found a total of 75 children, 44 with K. kingae and 31 with pyogenic infections (mostly MSSA, S. pneumoniae and S. pyogenes). K. kingae affected younger children with low or absent fever, low inflammatory markers and a favourable prognosis. In the univariate analyses, fever, septic look, CRP and ESR at admission and CRP at 48 h were significantly lower in K. kingae SA. In the multivariate analyses, age > 6 months ≤ 2 years, apyrexy and CRP ≤ 100 mg/L were significative, with an overall predictive positive value of 86.5%, and 88.4% for K. kingae. For this model, ROC curves were capable of differentiating (AUC 0.861, 95% CI 0.767-0.955) K. kingae SA from typical pathogens. (4) Conclusions: Age > 6 months ≤ 2 years, apyrexy and PCR ≤ 100 mg/L were the main predictive factors to distinguish K. kingae from pyogenic SA < 5 years. These data need to be validated in a larger study.MDPIRepositório Científico do Instituto Nacional de SaúdeGouveia, CatarinaSubtil, AnaNorte, SusanaArcangelo, JoanaSantos, Madalena AlmeidaCorte-Real, RitaSimões, Maria JoãoCanhão, HelenaTavares, Delfin2023-02-28T14:05:03Z2022-06-162022-06-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8538engMicroorganisms. 2022 Jun 16;10(6):1233. doi: 10.3390/microorganisms10061233.2076-260710.3390/microorganisms10061233info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:37Zoai:repositorio.insa.pt:10400.18/8538Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:10.755003Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
spellingShingle Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
Gouveia, Catarina
Kingella kingae
Acute Septic Arthritis
Pyogenic Infections
Diagnostics
Acute Septic Arthritis
Children
Portugal
Infecções Respiratórias
title_short Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title_full Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title_fullStr Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title_full_unstemmed Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
title_sort Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children
author Gouveia, Catarina
author_facet Gouveia, Catarina
Subtil, Ana
Norte, Susana
Arcangelo, Joana
Santos, Madalena Almeida
Corte-Real, Rita
Simões, Maria João
Canhão, Helena
Tavares, Delfin
author_role author
author2 Subtil, Ana
Norte, Susana
Arcangelo, Joana
Santos, Madalena Almeida
Corte-Real, Rita
Simões, Maria João
Canhão, Helena
Tavares, Delfin
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Gouveia, Catarina
Subtil, Ana
Norte, Susana
Arcangelo, Joana
Santos, Madalena Almeida
Corte-Real, Rita
Simões, Maria João
Canhão, Helena
Tavares, Delfin
dc.subject.por.fl_str_mv Kingella kingae
Acute Septic Arthritis
Pyogenic Infections
Diagnostics
Acute Septic Arthritis
Children
Portugal
Infecções Respiratórias
topic Kingella kingae
Acute Septic Arthritis
Pyogenic Infections
Diagnostics
Acute Septic Arthritis
Children
Portugal
Infecções Respiratórias
description This article belongs to the Special Issue Kingella kingae: Virulence Factors, Clinical Disease, and Diagnostics.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-16
2022-06-16T00:00:00Z
2023-02-28T14:05:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8538
url http://hdl.handle.net/10400.18/8538
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microorganisms. 2022 Jun 16;10(6):1233. doi: 10.3390/microorganisms10061233.
2076-2607
10.3390/microorganisms10061233
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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