The immune mechanisms of severe equine asthma : current understanding and what Is missing

Detalhes bibliográficos
Autor(a) principal: Simões, Joana
Data de Publicação: 2022
Outros Autores: Batista, M., Tilley, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24234
Resumo: Research Areas: Agriculture ; Veterinary Sciences ; Zoology
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spelling The immune mechanisms of severe equine asthma : current understanding and what Is missingSevere equine asthmaImmunologyGeneticNeutrophilsHorseResearch Areas: Agriculture ; Veterinary Sciences ; ZoologySevere equine asthma is a chronic respiratory disease of adult horses, occurring when genetically susceptible individuals are exposed to environmental aeroallergens. This results in airway inflammation, mucus accumulation and bronchial constriction. Although several studies aimed at evaluating the genetic and immune pathways associated with the disease, the results reported are inconsistent. Furthermore, the complexity and heterogeneity of this disease bears great similarity to what is described for human asthma. Currently available studies identified two chromosome regions (ECA13 and ECA15) and several genes associated with the disease. The inflammatory response appears to be mediated by T helper cells (Th1, Th2, Th17) and neutrophilic inflammation significantly contributes to the persistence of airway inflammatory status. This review evaluates the reported findings pertaining to the genetical and immunological background of severe equine asthma and reflects on their implications in the pathophysiology of the disease whilst discussing further areas of research interest aiming at advancing treatment and prognosis of affected individualsMDPIRepositório da Universidade de LisboaSimões, JoanaBatista, M.Tilley, Paula2022-05-04T22:30:53Z2022-03-162022-03-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24234engSimões J, Batista M, Tilley P. 2022. The immune mechanisms of severe equine asthma : current understanding and what Is missing. Animals 12(6):744. Doi 10.3390/ani120607442076-261510.3390/ani12060744info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:53Zoai:www.repository.utl.pt:10400.5/24234Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:19.862278Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The immune mechanisms of severe equine asthma : current understanding and what Is missing
title The immune mechanisms of severe equine asthma : current understanding and what Is missing
spellingShingle The immune mechanisms of severe equine asthma : current understanding and what Is missing
Simões, Joana
Severe equine asthma
Immunology
Genetic
Neutrophils
Horse
title_short The immune mechanisms of severe equine asthma : current understanding and what Is missing
title_full The immune mechanisms of severe equine asthma : current understanding and what Is missing
title_fullStr The immune mechanisms of severe equine asthma : current understanding and what Is missing
title_full_unstemmed The immune mechanisms of severe equine asthma : current understanding and what Is missing
title_sort The immune mechanisms of severe equine asthma : current understanding and what Is missing
author Simões, Joana
author_facet Simões, Joana
Batista, M.
Tilley, Paula
author_role author
author2 Batista, M.
Tilley, Paula
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Simões, Joana
Batista, M.
Tilley, Paula
dc.subject.por.fl_str_mv Severe equine asthma
Immunology
Genetic
Neutrophils
Horse
topic Severe equine asthma
Immunology
Genetic
Neutrophils
Horse
description Research Areas: Agriculture ; Veterinary Sciences ; Zoology
publishDate 2022
dc.date.none.fl_str_mv 2022-05-04T22:30:53Z
2022-03-16
2022-03-16T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24234
url http://hdl.handle.net/10400.5/24234
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Simões J, Batista M, Tilley P. 2022. The immune mechanisms of severe equine asthma : current understanding and what Is missing. Animals 12(6):744. Doi 10.3390/ani12060744
2076-2615
10.3390/ani12060744
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