Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients

Detalhes bibliográficos
Autor(a) principal: Bernardo, Vasco
Data de Publicação: 2012
Outros Autores: Luz, Gisela, Alves, N. M., Mano, J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/22728
Resumo: We report a new facile method for the development of crystallinity gradients in poly(l-lactic acid) films, based on the gradual dipping of amorphous PLLA samples in a hot bath. Isothermal cold crystallization studies were performed using DSC and optical microscopy in order to find adequate conditions to generate crystallinity gradients in the PLLA films. Cellular response along PLLA samples with graded spherulitic developments was tested: cell adhesion is higher in more crystalline zones due to highly flattened appearance of the cells in regions densely populated with spherulites, but cell density was found to be higher in the more amorphous side.
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spelling Cell behaviour in new poly(l-lactic acid) films with crystallinity gradientsPLLACrystallinity kineticsMorphologyBiomaterialsBiodegradableCell adhesionScience & TechnologyWe report a new facile method for the development of crystallinity gradients in poly(l-lactic acid) films, based on the gradual dipping of amorphous PLLA samples in a hot bath. Isothermal cold crystallization studies were performed using DSC and optical microscopy in order to find adequate conditions to generate crystallinity gradients in the PLLA films. Cellular response along PLLA samples with graded spherulitic developments was tested: cell adhesion is higher in more crystalline zones due to highly flattened appearance of the cells in regions densely populated with spherulites, but cell density was found to be higher in the more amorphous side.This work was financially supported by the Portuguese Foundation for Science and Technology (FCT)-Project PTDC/FIS/115048/2009.ElsevierElsevier BVUniversidade do MinhoBernardo, VascoLuz, GiselaAlves, N. M.Mano, J. F.2012-11-152012-11-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/22728eng0167-577X10.1016/j.matlet.2012.07.088http://dx.doi.org/10.1016/j.matlet.2012.07.088info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:49:09Zoai:repositorium.sdum.uminho.pt:1822/22728Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:47:34.683346Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients
title Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients
spellingShingle Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients
Bernardo, Vasco
PLLA
Crystallinity kinetics
Morphology
Biomaterials
Biodegradable
Cell adhesion
Science & Technology
title_short Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients
title_full Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients
title_fullStr Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients
title_full_unstemmed Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients
title_sort Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients
author Bernardo, Vasco
author_facet Bernardo, Vasco
Luz, Gisela
Alves, N. M.
Mano, J. F.
author_role author
author2 Luz, Gisela
Alves, N. M.
Mano, J. F.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Bernardo, Vasco
Luz, Gisela
Alves, N. M.
Mano, J. F.
dc.subject.por.fl_str_mv PLLA
Crystallinity kinetics
Morphology
Biomaterials
Biodegradable
Cell adhesion
Science & Technology
topic PLLA
Crystallinity kinetics
Morphology
Biomaterials
Biodegradable
Cell adhesion
Science & Technology
description We report a new facile method for the development of crystallinity gradients in poly(l-lactic acid) films, based on the gradual dipping of amorphous PLLA samples in a hot bath. Isothermal cold crystallization studies were performed using DSC and optical microscopy in order to find adequate conditions to generate crystallinity gradients in the PLLA films. Cellular response along PLLA samples with graded spherulitic developments was tested: cell adhesion is higher in more crystalline zones due to highly flattened appearance of the cells in regions densely populated with spherulites, but cell density was found to be higher in the more amorphous side.
publishDate 2012
dc.date.none.fl_str_mv 2012-11-15
2012-11-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/22728
url http://hdl.handle.net/1822/22728
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0167-577X
10.1016/j.matlet.2012.07.088
http://dx.doi.org/10.1016/j.matlet.2012.07.088
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
Elsevier BV
publisher.none.fl_str_mv Elsevier
Elsevier BV
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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