Statins and microalbuminuria
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://revista.spmi.pt/index.php/rpmi/article/view/1804 |
Resumo: | Microalbuminuria is at present considered an indicator of cardiovascular risk, often occurring associated with other cardiovascular risk factors and might be the renal marker for anincreased endothelial permeability that accompanies the atherogenic process. According tosome studies, the prevalence of microalbuminuria in the general population ranges from 3.8to 14.6%, being higher in diabetic and/or hypertensive individuals.Histopathological and experimental evidence suggest that dyslipidaemia can initiate andcontribute to the progression of nephropathy, with mechanisms similar to those involved inatherosclerosis; on the other hand, urinary albumin loss may lead to a rise in lipoprotein plasmatic levels.Lipid lowering therapy with statins has beenshown to reduce cardiovascular risk and also to improve endothelial function. Animal and invitro experiments have demonstrated beneficial effects of these drugs in several models ofnephropathy, including reductions in urinaryprotein excretion. Some studies conducted in patients with abnormal excretion of urinaryprotein support the hypothesis that reno-protective effects also occur in humans; however,the field is still open for investigation in thisarea, particularly the effect of statins in the reduction of microalbuminuria. |
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Statins and microalbuminuriaEstatinas e microalbuminúriamicroalbuminúriaestatinasdislipidemianefropatiamicroalbuminuriastatinsdyslipidaemianephropathyMicroalbuminuria is at present considered an indicator of cardiovascular risk, often occurring associated with other cardiovascular risk factors and might be the renal marker for anincreased endothelial permeability that accompanies the atherogenic process. According tosome studies, the prevalence of microalbuminuria in the general population ranges from 3.8to 14.6%, being higher in diabetic and/or hypertensive individuals.Histopathological and experimental evidence suggest that dyslipidaemia can initiate andcontribute to the progression of nephropathy, with mechanisms similar to those involved inatherosclerosis; on the other hand, urinary albumin loss may lead to a rise in lipoprotein plasmatic levels.Lipid lowering therapy with statins has beenshown to reduce cardiovascular risk and also to improve endothelial function. Animal and invitro experiments have demonstrated beneficial effects of these drugs in several models ofnephropathy, including reductions in urinaryprotein excretion. Some studies conducted in patients with abnormal excretion of urinaryprotein support the hypothesis that reno-protective effects also occur in humans; however,the field is still open for investigation in thisarea, particularly the effect of statins in the reduction of microalbuminuria.A microalbuminúria é, actualmente, considerada um indicador de risco cardiovascular,ocorrendo frequentemente associada a outrosfactores de risco aterosclerótico e podendo representar o marcador renal do aumento generalizado da permeabilidade endotelial que acompanha o processo aterogénico. Segundoalguns estudos, a prevalência da microalbuminúria na população geral varia entre 3,8 e14,6%, verificando-se prevalências mais elevadas nos diabéticos e ou hipertensos.Evidências histopatológicas e experimentaissugerem que a dislipidemia pode iniciar e contribuir para a progressão da nefropatia, sendo os mecanismos implicados semelhantes aos envolvidos na aterosclerose; por outro lado, aperda urinária de albumina pode levar a elevação dos níveis plasmáticos das lipoproteínasA terapêutica hipolipemiante com estatinas demonstrou reduzir o risco cardiovascular e,também, melhorar a função endotelial. Estudosem animais e in vitro demonstraram efeitosbenéficos destes fármacos em vários modelos de nefropatia, incluindo reduções da excreçãourinária de proteínas. Alguns estudos realizados em doentes com excreção anormal de proteínas na urina apoiam a hipótese de que os efeitos renoprotectores também ocorram em humanos, continuando, ainda em aberto, noentanto, o campo para investigação nesta área, particularmente sobre o efeito das estatinas na redução da microalbuminúria.Sociedade Portuguesa de Medicina Interna2003-06-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://revista.spmi.pt/index.php/rpmi/article/view/1804Internal Medicine; Vol. 10 No. 2 (2003): Abril/ Junho; 101-109Medicina Interna; Vol. 10 N.º 2 (2003): Abril/ Junho; 101-1092183-99800872-671Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spmi.pt/index.php/rpmi/article/view/1804https://revista.spmi.pt/index.php/rpmi/article/view/1804/1255Dias, PatríciaSilva, José ManuelSilva, NunoAlexandrino, M. B.Alves de Moura, J. J.info:eu-repo/semantics/openAccess2023-05-27T06:10:40Zoai:oai.revista.spmi.pt:article/1804Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:56:21.524282Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Statins and microalbuminuria Estatinas e microalbuminúria |
title |
Statins and microalbuminuria |
spellingShingle |
Statins and microalbuminuria Dias, Patrícia microalbuminúria estatinas dislipidemia nefropatia microalbuminuria statins dyslipidaemia nephropathy |
title_short |
Statins and microalbuminuria |
title_full |
Statins and microalbuminuria |
title_fullStr |
Statins and microalbuminuria |
title_full_unstemmed |
Statins and microalbuminuria |
title_sort |
Statins and microalbuminuria |
author |
Dias, Patrícia |
author_facet |
Dias, Patrícia Silva, José Manuel Silva, Nuno Alexandrino, M. B. Alves de Moura, J. J. |
author_role |
author |
author2 |
Silva, José Manuel Silva, Nuno Alexandrino, M. B. Alves de Moura, J. J. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Dias, Patrícia Silva, José Manuel Silva, Nuno Alexandrino, M. B. Alves de Moura, J. J. |
dc.subject.por.fl_str_mv |
microalbuminúria estatinas dislipidemia nefropatia microalbuminuria statins dyslipidaemia nephropathy |
topic |
microalbuminúria estatinas dislipidemia nefropatia microalbuminuria statins dyslipidaemia nephropathy |
description |
Microalbuminuria is at present considered an indicator of cardiovascular risk, often occurring associated with other cardiovascular risk factors and might be the renal marker for anincreased endothelial permeability that accompanies the atherogenic process. According tosome studies, the prevalence of microalbuminuria in the general population ranges from 3.8to 14.6%, being higher in diabetic and/or hypertensive individuals.Histopathological and experimental evidence suggest that dyslipidaemia can initiate andcontribute to the progression of nephropathy, with mechanisms similar to those involved inatherosclerosis; on the other hand, urinary albumin loss may lead to a rise in lipoprotein plasmatic levels.Lipid lowering therapy with statins has beenshown to reduce cardiovascular risk and also to improve endothelial function. Animal and invitro experiments have demonstrated beneficial effects of these drugs in several models ofnephropathy, including reductions in urinaryprotein excretion. Some studies conducted in patients with abnormal excretion of urinaryprotein support the hypothesis that reno-protective effects also occur in humans; however,the field is still open for investigation in thisarea, particularly the effect of statins in the reduction of microalbuminuria. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-06-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.spmi.pt/index.php/rpmi/article/view/1804 |
url |
https://revista.spmi.pt/index.php/rpmi/article/view/1804 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.spmi.pt/index.php/rpmi/article/view/1804 https://revista.spmi.pt/index.php/rpmi/article/view/1804/1255 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Medicina Interna |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Medicina Interna |
dc.source.none.fl_str_mv |
Internal Medicine; Vol. 10 No. 2 (2003): Abril/ Junho; 101-109 Medicina Interna; Vol. 10 N.º 2 (2003): Abril/ Junho; 101-109 2183-9980 0872-671X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131638863495168 |