Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis

Detalhes bibliográficos
Autor(a) principal: Lima, Fabianne Soares
Data de Publicação: 2022
Outros Autores: Matos, Luis Felipe, Pacheco, Isnayra Kerolaynne, Reis, Fernando, Câmara, João Victor Frazão, Pierote, Josué Junior Araujo, Matos, José Milton, Ribeiro, Alessandra, Moura, Walter, Fialho, Ana Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/36877
Resumo: To analyze the biocompatibility of the scaffold produced from a natural polymer derived from castor oil through hemolytic activity and antimicrobial activity, to enable the clinical application. Three in vitro tests were performed: Hemolytic activity test - Polymer partially dissolved in contact with blood agar; Hemolytic activity test in sheep's blood - Polymer extract with red blood cells solution; Antimicrobial activity test - Solid polymer in direct contact with E. Coli and S. Aureus. For hemolytic tests, none of the samples showed hemolysis. Negative hemolytic activity is a good indicator, as the maintenance of the blood clot in the area of the lesion is essential for the formation of new tissue. For the antimicrobial activity test, no significant activity was observed against the bacteria used. The polymer is not toxic to red blood cells, being viable for clinical application as a matrix for tissue regeneration.
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spelling Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysisBone matrixMaterials testingTissue scaffoldsTo analyze the biocompatibility of the scaffold produced from a natural polymer derived from castor oil through hemolytic activity and antimicrobial activity, to enable the clinical application. Three in vitro tests were performed: Hemolytic activity test - Polymer partially dissolved in contact with blood agar; Hemolytic activity test in sheep's blood - Polymer extract with red blood cells solution; Antimicrobial activity test - Solid polymer in direct contact with E. Coli and S. Aureus. For hemolytic tests, none of the samples showed hemolysis. Negative hemolytic activity is a good indicator, as the maintenance of the blood clot in the area of the lesion is essential for the formation of new tissue. For the antimicrobial activity test, no significant activity was observed against the bacteria used. The polymer is not toxic to red blood cells, being viable for clinical application as a matrix for tissue regeneration.Veritati - Repositório Institucional da Universidade Católica PortuguesaLima, Fabianne SoaresMatos, Luis FelipePacheco, Isnayra KerolaynneReis, FernandoCâmara, João Victor FrazãoPierote, Josué Junior AraujoMatos, José MiltonRibeiro, AlessandraMoura, WalterFialho, Ana Cristina2022-03-04T10:47:15Z2022-01-312022-01-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/36877eng0104-142810.1590/0104-1428.21001885124316267info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-23T01:41:47Zoai:repositorio.ucp.pt:10400.14/36877Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:29:59.024304Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis
title Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis
spellingShingle Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis
Lima, Fabianne Soares
Bone matrix
Materials testing
Tissue scaffolds
title_short Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis
title_full Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis
title_fullStr Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis
title_full_unstemmed Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis
title_sort Scaffold based on castor oil as an osteoconductive matrix in bone repair: biocompatibility analysis
author Lima, Fabianne Soares
author_facet Lima, Fabianne Soares
Matos, Luis Felipe
Pacheco, Isnayra Kerolaynne
Reis, Fernando
Câmara, João Victor Frazão
Pierote, Josué Junior Araujo
Matos, José Milton
Ribeiro, Alessandra
Moura, Walter
Fialho, Ana Cristina
author_role author
author2 Matos, Luis Felipe
Pacheco, Isnayra Kerolaynne
Reis, Fernando
Câmara, João Victor Frazão
Pierote, Josué Junior Araujo
Matos, José Milton
Ribeiro, Alessandra
Moura, Walter
Fialho, Ana Cristina
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Lima, Fabianne Soares
Matos, Luis Felipe
Pacheco, Isnayra Kerolaynne
Reis, Fernando
Câmara, João Victor Frazão
Pierote, Josué Junior Araujo
Matos, José Milton
Ribeiro, Alessandra
Moura, Walter
Fialho, Ana Cristina
dc.subject.por.fl_str_mv Bone matrix
Materials testing
Tissue scaffolds
topic Bone matrix
Materials testing
Tissue scaffolds
description To analyze the biocompatibility of the scaffold produced from a natural polymer derived from castor oil through hemolytic activity and antimicrobial activity, to enable the clinical application. Three in vitro tests were performed: Hemolytic activity test - Polymer partially dissolved in contact with blood agar; Hemolytic activity test in sheep's blood - Polymer extract with red blood cells solution; Antimicrobial activity test - Solid polymer in direct contact with E. Coli and S. Aureus. For hemolytic tests, none of the samples showed hemolysis. Negative hemolytic activity is a good indicator, as the maintenance of the blood clot in the area of the lesion is essential for the formation of new tissue. For the antimicrobial activity test, no significant activity was observed against the bacteria used. The polymer is not toxic to red blood cells, being viable for clinical application as a matrix for tissue regeneration.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-04T10:47:15Z
2022-01-31
2022-01-31T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/36877
url http://hdl.handle.net/10400.14/36877
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0104-1428
10.1590/0104-1428.210018
85124316267
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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