Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples

Detalhes bibliográficos
Autor(a) principal: Manco, Licínio
Data de Publicação: 2009
Outros Autores: Machado, Patrícia, Lopes, Dinora, Nogueira, Fátima, Rosário, Virgílio E. do, Alonso, Pedro L., Varandas, Luís, Trovoada, Maria de Jesus, Amorim, António, Arez, Ana Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/8070
https://doi.org/10.1002/ajhb.20819
Resumo: Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem
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spelling Analysis of TPI gene promoter variation in three sub-Saharan Africa population samplesPopulation samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problemWiley-Liss2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8070http://hdl.handle.net/10316/8070https://doi.org/10.1002/ajhb.20819engAmerican Journal of Human Biology. 21:1 (2009) 118-120Manco, LicínioMachado, PatríciaLopes, DinoraNogueira, FátimaRosário, Virgílio E. doAlonso, Pedro L.Varandas, LuísTrovoada, Maria de JesusAmorim, AntónioArez, Ana Paulainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-11-05T10:15:11Zoai:estudogeral.uc.pt:10316/8070Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:55.241996Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
title Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
spellingShingle Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
Manco, Licínio
title_short Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
title_full Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
title_fullStr Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
title_full_unstemmed Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
title_sort Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
author Manco, Licínio
author_facet Manco, Licínio
Machado, Patrícia
Lopes, Dinora
Nogueira, Fátima
Rosário, Virgílio E. do
Alonso, Pedro L.
Varandas, Luís
Trovoada, Maria de Jesus
Amorim, António
Arez, Ana Paula
author_role author
author2 Machado, Patrícia
Lopes, Dinora
Nogueira, Fátima
Rosário, Virgílio E. do
Alonso, Pedro L.
Varandas, Luís
Trovoada, Maria de Jesus
Amorim, António
Arez, Ana Paula
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Manco, Licínio
Machado, Patrícia
Lopes, Dinora
Nogueira, Fátima
Rosário, Virgílio E. do
Alonso, Pedro L.
Varandas, Luís
Trovoada, Maria de Jesus
Amorim, António
Arez, Ana Paula
description Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/8070
http://hdl.handle.net/10316/8070
https://doi.org/10.1002/ajhb.20819
url http://hdl.handle.net/10316/8070
https://doi.org/10.1002/ajhb.20819
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv American Journal of Human Biology. 21:1 (2009) 118-120
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-Liss
publisher.none.fl_str_mv Wiley-Liss
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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