Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/8070 https://doi.org/10.1002/ajhb.20819 |
Resumo: | Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Analysis of TPI gene promoter variation in three sub-Saharan Africa population samplesPopulation samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problemWiley-Liss2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8070http://hdl.handle.net/10316/8070https://doi.org/10.1002/ajhb.20819engAmerican Journal of Human Biology. 21:1 (2009) 118-120Manco, LicínioMachado, PatríciaLopes, DinoraNogueira, FátimaRosário, Virgílio E. doAlonso, Pedro L.Varandas, LuísTrovoada, Maria de JesusAmorim, AntónioArez, Ana Paulainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-11-05T10:15:11Zoai:estudogeral.uc.pt:10316/8070Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:55.241996Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples |
title |
Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples |
spellingShingle |
Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples Manco, Licínio |
title_short |
Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples |
title_full |
Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples |
title_fullStr |
Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples |
title_full_unstemmed |
Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples |
title_sort |
Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples |
author |
Manco, Licínio |
author_facet |
Manco, Licínio Machado, Patrícia Lopes, Dinora Nogueira, Fátima Rosário, Virgílio E. do Alonso, Pedro L. Varandas, Luís Trovoada, Maria de Jesus Amorim, António Arez, Ana Paula |
author_role |
author |
author2 |
Machado, Patrícia Lopes, Dinora Nogueira, Fátima Rosário, Virgílio E. do Alonso, Pedro L. Varandas, Luís Trovoada, Maria de Jesus Amorim, António Arez, Ana Paula |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Manco, Licínio Machado, Patrícia Lopes, Dinora Nogueira, Fátima Rosário, Virgílio E. do Alonso, Pedro L. Varandas, Luís Trovoada, Maria de Jesus Amorim, António Arez, Ana Paula |
description |
Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/8070 http://hdl.handle.net/10316/8070 https://doi.org/10.1002/ajhb.20819 |
url |
http://hdl.handle.net/10316/8070 https://doi.org/10.1002/ajhb.20819 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Human Biology. 21:1 (2009) 118-120 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Wiley-Liss |
publisher.none.fl_str_mv |
Wiley-Liss |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133844949958656 |