Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review

Detalhes bibliográficos
Autor(a) principal: Viegas, Carla
Data de Publicação: 2022
Outros Autores: Pena, Pedro, Gomes, Bianca, Dias, Marta, Caetano, Liliana Aranha, Viegas, Susana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/14277
Resumo: Project “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL).
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spelling Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic reviewOccupational healthOccupational exposureMultiple contaminantsEnvironmental samplesIn vitro studiesCytotoxicityRisk managementProject Occupational exposure of ambulance drivers to bioburdenProject IPL/2020/BIO-AmbuDrivers_ESTeSLFCT_UIDB/05608/2020FCT_UIDP/05608/2020Project “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL).FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.In some occupational environments, risk characterization is challenging or impossible to achieve due to the presence of multiple pollutants and contaminants. Thus, in vitro testing using the most relevant cell lines will provide information concerning health effects due to the co-exposure to multiple stressors. The aim of this review article is to identify studies where the cytotoxicity assessment was performed in environmental samples, as well as to describe the main outputs and challenges regarding risk characterization and management. This study is based on a study of the available information/data on cytotoxicity assessment performed on environmental samples following the PRISMA methodology. Different cell lines were used depending on the environment assessed and exposure routes implicated. The A549 alveolar epithelial cell line was applied in four studies for occupational exposure in the waste sorting industry and for outdoor environments; lymphocytes were used in two studies for occupational and outdoor environments; swine kidney cells were used in three studies performed in the waste industry and hepatocellular/Hep G2 in one study in the waste industry. Cytotoxicity assessments in environmental samples should have a more prominent role due to their contribution to identifying and better understanding the associations between co-exposure to environmental contaminants and adverse human health effects as a prioritization for risk management.MDPIRCIPLViegas, CarlaPena, PedroGomes, BiancaDias, MartaCaetano, Liliana AranhaViegas, Susana2022-02-09T16:04:50Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14277engViegas C, Pena P, Gomes B, Dias M, Caetano LA, Viegas S. Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review. Toxics. 2022;10(2):72.10.3390/toxics10020072info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:10:12Zoai:repositorio.ipl.pt:10400.21/14277Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:06.558827Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
title Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
spellingShingle Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
Viegas, Carla
Occupational health
Occupational exposure
Multiple contaminants
Environmental samples
In vitro studies
Cytotoxicity
Risk management
Project Occupational exposure of ambulance drivers to bioburden
Project IPL/2020/BIO-AmbuDrivers_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
title_full Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
title_fullStr Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
title_full_unstemmed Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
title_sort Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
author Viegas, Carla
author_facet Viegas, Carla
Pena, Pedro
Gomes, Bianca
Dias, Marta
Caetano, Liliana Aranha
Viegas, Susana
author_role author
author2 Pena, Pedro
Gomes, Bianca
Dias, Marta
Caetano, Liliana Aranha
Viegas, Susana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Viegas, Carla
Pena, Pedro
Gomes, Bianca
Dias, Marta
Caetano, Liliana Aranha
Viegas, Susana
dc.subject.por.fl_str_mv Occupational health
Occupational exposure
Multiple contaminants
Environmental samples
In vitro studies
Cytotoxicity
Risk management
Project Occupational exposure of ambulance drivers to bioburden
Project IPL/2020/BIO-AmbuDrivers_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic Occupational health
Occupational exposure
Multiple contaminants
Environmental samples
In vitro studies
Cytotoxicity
Risk management
Project Occupational exposure of ambulance drivers to bioburden
Project IPL/2020/BIO-AmbuDrivers_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description Project “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL).
publishDate 2022
dc.date.none.fl_str_mv 2022-02-09T16:04:50Z
2022-02
2022-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14277
url http://hdl.handle.net/10400.21/14277
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Viegas C, Pena P, Gomes B, Dias M, Caetano LA, Viegas S. Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review. Toxics. 2022;10(2):72.
10.3390/toxics10020072
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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