Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/14277 |
Resumo: | Project “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL). |
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Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic reviewOccupational healthOccupational exposureMultiple contaminantsEnvironmental samplesIn vitro studiesCytotoxicityRisk managementProject Occupational exposure of ambulance drivers to bioburdenProject IPL/2020/BIO-AmbuDrivers_ESTeSLFCT_UIDB/05608/2020FCT_UIDP/05608/2020Project “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL).FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.In some occupational environments, risk characterization is challenging or impossible to achieve due to the presence of multiple pollutants and contaminants. Thus, in vitro testing using the most relevant cell lines will provide information concerning health effects due to the co-exposure to multiple stressors. The aim of this review article is to identify studies where the cytotoxicity assessment was performed in environmental samples, as well as to describe the main outputs and challenges regarding risk characterization and management. This study is based on a study of the available information/data on cytotoxicity assessment performed on environmental samples following the PRISMA methodology. Different cell lines were used depending on the environment assessed and exposure routes implicated. The A549 alveolar epithelial cell line was applied in four studies for occupational exposure in the waste sorting industry and for outdoor environments; lymphocytes were used in two studies for occupational and outdoor environments; swine kidney cells were used in three studies performed in the waste industry and hepatocellular/Hep G2 in one study in the waste industry. Cytotoxicity assessments in environmental samples should have a more prominent role due to their contribution to identifying and better understanding the associations between co-exposure to environmental contaminants and adverse human health effects as a prioritization for risk management.MDPIRCIPLViegas, CarlaPena, PedroGomes, BiancaDias, MartaCaetano, Liliana AranhaViegas, Susana2022-02-09T16:04:50Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14277engViegas C, Pena P, Gomes B, Dias M, Caetano LA, Viegas S. Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review. Toxics. 2022;10(2):72.10.3390/toxics10020072info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:10:12Zoai:repositorio.ipl.pt:10400.21/14277Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:06.558827Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review |
title |
Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review |
spellingShingle |
Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review Viegas, Carla Occupational health Occupational exposure Multiple contaminants Environmental samples In vitro studies Cytotoxicity Risk management Project Occupational exposure of ambulance drivers to bioburden Project IPL/2020/BIO-AmbuDrivers_ESTeSL FCT_UIDB/05608/2020 FCT_UIDP/05608/2020 |
title_short |
Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review |
title_full |
Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review |
title_fullStr |
Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review |
title_full_unstemmed |
Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review |
title_sort |
Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review |
author |
Viegas, Carla |
author_facet |
Viegas, Carla Pena, Pedro Gomes, Bianca Dias, Marta Caetano, Liliana Aranha Viegas, Susana |
author_role |
author |
author2 |
Pena, Pedro Gomes, Bianca Dias, Marta Caetano, Liliana Aranha Viegas, Susana |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Viegas, Carla Pena, Pedro Gomes, Bianca Dias, Marta Caetano, Liliana Aranha Viegas, Susana |
dc.subject.por.fl_str_mv |
Occupational health Occupational exposure Multiple contaminants Environmental samples In vitro studies Cytotoxicity Risk management Project Occupational exposure of ambulance drivers to bioburden Project IPL/2020/BIO-AmbuDrivers_ESTeSL FCT_UIDB/05608/2020 FCT_UIDP/05608/2020 |
topic |
Occupational health Occupational exposure Multiple contaminants Environmental samples In vitro studies Cytotoxicity Risk management Project Occupational exposure of ambulance drivers to bioburden Project IPL/2020/BIO-AmbuDrivers_ESTeSL FCT_UIDB/05608/2020 FCT_UIDP/05608/2020 |
description |
Project “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-09T16:04:50Z 2022-02 2022-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/14277 |
url |
http://hdl.handle.net/10400.21/14277 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Viegas C, Pena P, Gomes B, Dias M, Caetano LA, Viegas S. Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review. Toxics. 2022;10(2):72. 10.3390/toxics10020072 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133492721745920 |