Association of the practice of contact sports with the development of amyotrophic lateral sclerosis

Detalhes bibliográficos
Autor(a) principal: Henriques, Ana
Data de Publicação: 2023
Outros Autores: Gromicho, Marta, Grosskreutz, Julian, Kuzma-Kozakiewicz, Magdalena, Petri, Susanne, Uysal, Hilmi, Pinto, Susana, Antunes, Marilia, Carvalho, Mamede, Ribeiro, Ruy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/58801
Resumo: © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
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spelling Association of the practice of contact sports with the development of amyotrophic lateral sclerosisAmyotrophic lateral sclerosisContact sportsRisk-factorSmokingTrauma© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.Objectives: High-intensity physical activity and sports prone to repetitive injuries of the cervical spine and head (when associated with vigorous practice) have been suggested as possible risk factors for amyotrophic lateral sclerosis (ALS). Our objective was to evaluate the relationship between the practice of contact sports (boxing, hockey, football, rugby) and ALS. Methods: The study included 2247 individuals, 1326 patients and 921 controls from several European countries. Analysis of the effect of contact sports on ALS was conducted in male participants only, as very few women practiced contact sports. Logistic regression models were used with the response variable as the presence or absence of ALS, with α = 0.05 significance level. Results: A relationship between the practice of contact sports and ALS was found, with those practicing contact sports having 76% higher odds of an ALS diagnosis (OR = 1.76, p = 0.001). In addition, univariate analyses for age (higher risk for older people, p < 0.001), smoking status (higher risk for ex-smokers, p = 0.022) and tobacco exposure (higher risk for more exposure, p = 0.038) also indicated that these variables are risk factors for ALS. In multivariate models, in addition to age, the interaction term between practice of contact sports and tobacco exposure was still significant (p = 0.03). Conclusions: This is one of the largest studies on the role of contact sport in ALS development. Our results support the existence of a relationship between the practice of sports with repetitive trauma at the level of the cervical spine and head, and ALS. This risk appears to be enhanced by tobacco exposure.This study is included in the ONWebDUALS project [JPND-PS/0001/2013] initiative. This is an EU Joint Program – Neurodegenerative Disease Research (JPND) project – Fundação para a Ciência e a Tecnologia [JPND-PS/0001/2013]. Partial funding also from project [PTDC/MAT-APL/31602/2017] (RMR) from Fundação para a Ciência e a Tecnologia.Taylor & FrancisRepositório da Universidade de LisboaHenriques, AnaGromicho, MartaGrosskreutz, JulianKuzma-Kozakiewicz, MagdalenaPetri, SusanneUysal, HilmiPinto, SusanaAntunes, MariliaCarvalho, MamedeRibeiro, Ruy2023-07-31T13:32:18Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58801engAmyotroph Lateral Scler Frontotemporal Degener. 2023 Aug;24(5-6):449-4562167-842110.1080/21678421.2023.21899112167-9223info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:07:45Zoai:repositorio.ul.pt:10451/58801Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:56.393466Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
title Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
spellingShingle Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
Henriques, Ana
Amyotrophic lateral sclerosis
Contact sports
Risk-factor
Smoking
Trauma
title_short Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
title_full Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
title_fullStr Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
title_full_unstemmed Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
title_sort Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
author Henriques, Ana
author_facet Henriques, Ana
Gromicho, Marta
Grosskreutz, Julian
Kuzma-Kozakiewicz, Magdalena
Petri, Susanne
Uysal, Hilmi
Pinto, Susana
Antunes, Marilia
Carvalho, Mamede
Ribeiro, Ruy
author_role author
author2 Gromicho, Marta
Grosskreutz, Julian
Kuzma-Kozakiewicz, Magdalena
Petri, Susanne
Uysal, Hilmi
Pinto, Susana
Antunes, Marilia
Carvalho, Mamede
Ribeiro, Ruy
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Henriques, Ana
Gromicho, Marta
Grosskreutz, Julian
Kuzma-Kozakiewicz, Magdalena
Petri, Susanne
Uysal, Hilmi
Pinto, Susana
Antunes, Marilia
Carvalho, Mamede
Ribeiro, Ruy
dc.subject.por.fl_str_mv Amyotrophic lateral sclerosis
Contact sports
Risk-factor
Smoking
Trauma
topic Amyotrophic lateral sclerosis
Contact sports
Risk-factor
Smoking
Trauma
description © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-31T13:32:18Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/58801
url http://hdl.handle.net/10451/58801
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Amyotroph Lateral Scler Frontotemporal Degener. 2023 Aug;24(5-6):449-456
2167-8421
10.1080/21678421.2023.2189911
2167-9223
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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