Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)

Detalhes bibliográficos
Autor(a) principal: Araújo, Nuna
Data de Publicação: 2021
Outros Autores: Viegas, Carla, Pontes, Jorge Filipe, Marreiros, Catarina, Raimundo, Pedro, Macedo, Anjos L., Alves de Matos, António, Grenha, Ana, Vermeer, Cees, Simes, Dina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/17248
Resumo: Gla rich protein (GRP) is a vitamin K dependent protein, shown to function as an inhibitor of pathological calcification and as an anti-inflammatory agent, with potential therapeutic use for age-related diseases such as osteoarthritis (OA) [1,2]. OA is a leading cause of disability and morbidity in the older population and constitutes a major world wide challenge for our health system. Presently, there are no drugs approved that can prevent, stop, or even restrain progression of OA. GRP has been shown to be able to lower inflammation and mineralisation processes in the articular tissue. Chitosan/tripolyphosphate (TPP) nanoparticles were selected for this study due to their biocompatibility, biodegradability and capacity to overcome the problem of low solubility of GRP in physiological conditions. This study aims to produce and characterise chitosan/TPP nanoparticles as GRP-delivery vehicles and test its anti-inflammatory potential in human macrophages.
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spelling Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)Nanoencapsulação como uma nova abordagem de entrega para aplicações terapêuticas de proteína rica em gla (GRP)Gla rich protein (GRP) is a vitamin K dependent protein, shown to function as an inhibitor of pathological calcification and as an anti-inflammatory agent, with potential therapeutic use for age-related diseases such as osteoarthritis (OA) [1,2]. OA is a leading cause of disability and morbidity in the older population and constitutes a major world wide challenge for our health system. Presently, there are no drugs approved that can prevent, stop, or even restrain progression of OA. GRP has been shown to be able to lower inflammation and mineralisation processes in the articular tissue. Chitosan/tripolyphosphate (TPP) nanoparticles were selected for this study due to their biocompatibility, biodegradability and capacity to overcome the problem of low solubility of GRP in physiological conditions. This study aims to produce and characterise chitosan/TPP nanoparticles as GRP-delivery vehicles and test its anti-inflammatory potential in human macrophages.Taylor & FrancisSapientiaAraújo, NunaViegas, CarlaPontes, Jorge FilipeMarreiros, CatarinaRaimundo, PedroMacedo, Anjos L.Alves de Matos, AntónioGrenha, AnaVermeer, CeesSimes, Dina2021-10-22T14:33:54Z2021-042021-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/17248eng10.1080/07853890.2021.18969001365-2060info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:29:24Zoai:sapientia.ualg.pt:10400.1/17248Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:07:16.567581Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
Nanoencapsulação como uma nova abordagem de entrega para aplicações terapêuticas de proteína rica em gla (GRP)
title Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
spellingShingle Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
Araújo, Nuna
title_short Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
title_full Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
title_fullStr Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
title_full_unstemmed Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
title_sort Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
author Araújo, Nuna
author_facet Araújo, Nuna
Viegas, Carla
Pontes, Jorge Filipe
Marreiros, Catarina
Raimundo, Pedro
Macedo, Anjos L.
Alves de Matos, António
Grenha, Ana
Vermeer, Cees
Simes, Dina
author_role author
author2 Viegas, Carla
Pontes, Jorge Filipe
Marreiros, Catarina
Raimundo, Pedro
Macedo, Anjos L.
Alves de Matos, António
Grenha, Ana
Vermeer, Cees
Simes, Dina
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Araújo, Nuna
Viegas, Carla
Pontes, Jorge Filipe
Marreiros, Catarina
Raimundo, Pedro
Macedo, Anjos L.
Alves de Matos, António
Grenha, Ana
Vermeer, Cees
Simes, Dina
description Gla rich protein (GRP) is a vitamin K dependent protein, shown to function as an inhibitor of pathological calcification and as an anti-inflammatory agent, with potential therapeutic use for age-related diseases such as osteoarthritis (OA) [1,2]. OA is a leading cause of disability and morbidity in the older population and constitutes a major world wide challenge for our health system. Presently, there are no drugs approved that can prevent, stop, or even restrain progression of OA. GRP has been shown to be able to lower inflammation and mineralisation processes in the articular tissue. Chitosan/tripolyphosphate (TPP) nanoparticles were selected for this study due to their biocompatibility, biodegradability and capacity to overcome the problem of low solubility of GRP in physiological conditions. This study aims to produce and characterise chitosan/TPP nanoparticles as GRP-delivery vehicles and test its anti-inflammatory potential in human macrophages.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-22T14:33:54Z
2021-04
2021-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/17248
url http://hdl.handle.net/10400.1/17248
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1080/07853890.2021.1896900
1365-2060
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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