Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats

Detalhes bibliográficos
Autor(a) principal: Paula, Anabela Baptista
Data de Publicação: 2015
Outros Autores: Dias, Maria Isabel, Ferreira, Manuel Marques, Carrilho, Teresa, Marto, Carlos Miguel, Casalta, João, Cabrita, António, Carrilho, Eunice
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.1590/1678-775720150235
Texto Completo: http://hdl.handle.net/10316/109177
https://doi.org/10.1590/1678-775720150235
Resumo: The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed. Objective: This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals. Material and Methods: Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically signicant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa. Results: The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group. Conclusion: Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.
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spelling Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in ratsAmbulatory monitoringBleaching agentsGastritisHydrogen peroxideTooth bleachingToxicityAnimalsBody WeightEthanolGastric MucosaHydrogen PeroxideOrgan SizeRats, WistarSpleenTime FactorsTooth BleachingTooth Bleaching AgentsThe value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed. Objective: This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals. Material and Methods: Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically signicant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa. Results: The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group. Conclusion: Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.Faculdade de Odontologia de Bauru2015-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109177http://hdl.handle.net/10316/109177https://doi.org/10.1590/1678-775720150235eng1678-7757Paula, Anabela BaptistaDias, Maria IsabelFerreira, Manuel MarquesCarrilho, TeresaMarto, Carlos MiguelCasalta, JoãoCabrita, AntónioCarrilho, Euniceinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-29T15:37:14Zoai:estudogeral.uc.pt:10316/109177Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:22.400147Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
title Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
spellingShingle Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
Paula, Anabela Baptista
Ambulatory monitoring
Bleaching agents
Gastritis
Hydrogen peroxide
Tooth bleaching
Toxicity
Animals
Body Weight
Ethanol
Gastric Mucosa
Hydrogen Peroxide
Organ Size
Rats, Wistar
Spleen
Time Factors
Tooth Bleaching
Tooth Bleaching Agents
Paula, Anabela Baptista
Ambulatory monitoring
Bleaching agents
Gastritis
Hydrogen peroxide
Tooth bleaching
Toxicity
Animals
Body Weight
Ethanol
Gastric Mucosa
Hydrogen Peroxide
Organ Size
Rats, Wistar
Spleen
Time Factors
Tooth Bleaching
Tooth Bleaching Agents
title_short Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
title_full Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
title_fullStr Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
title_full_unstemmed Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
title_sort Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
author Paula, Anabela Baptista
author_facet Paula, Anabela Baptista
Paula, Anabela Baptista
Dias, Maria Isabel
Ferreira, Manuel Marques
Carrilho, Teresa
Marto, Carlos Miguel
Casalta, João
Cabrita, António
Carrilho, Eunice
Dias, Maria Isabel
Ferreira, Manuel Marques
Carrilho, Teresa
Marto, Carlos Miguel
Casalta, João
Cabrita, António
Carrilho, Eunice
author_role author
author2 Dias, Maria Isabel
Ferreira, Manuel Marques
Carrilho, Teresa
Marto, Carlos Miguel
Casalta, João
Cabrita, António
Carrilho, Eunice
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paula, Anabela Baptista
Dias, Maria Isabel
Ferreira, Manuel Marques
Carrilho, Teresa
Marto, Carlos Miguel
Casalta, João
Cabrita, António
Carrilho, Eunice
dc.subject.por.fl_str_mv Ambulatory monitoring
Bleaching agents
Gastritis
Hydrogen peroxide
Tooth bleaching
Toxicity
Animals
Body Weight
Ethanol
Gastric Mucosa
Hydrogen Peroxide
Organ Size
Rats, Wistar
Spleen
Time Factors
Tooth Bleaching
Tooth Bleaching Agents
topic Ambulatory monitoring
Bleaching agents
Gastritis
Hydrogen peroxide
Tooth bleaching
Toxicity
Animals
Body Weight
Ethanol
Gastric Mucosa
Hydrogen Peroxide
Organ Size
Rats, Wistar
Spleen
Time Factors
Tooth Bleaching
Tooth Bleaching Agents
description The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed. Objective: This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals. Material and Methods: Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically signicant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa. Results: The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group. Conclusion: Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109177
http://hdl.handle.net/10316/109177
https://doi.org/10.1590/1678-775720150235
url http://hdl.handle.net/10316/109177
https://doi.org/10.1590/1678-775720150235
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1678-7757
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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dc.identifier.doi.none.fl_str_mv 10.1590/1678-775720150235