Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
DOI: | 10.1590/1678-775720150235 |
Texto Completo: | http://hdl.handle.net/10316/109177 https://doi.org/10.1590/1678-775720150235 |
Resumo: | The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed. Objective: This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals. Material and Methods: Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically signicant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa. Results: The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group. Conclusion: Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized. |
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Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in ratsAmbulatory monitoringBleaching agentsGastritisHydrogen peroxideTooth bleachingToxicityAnimalsBody WeightEthanolGastric MucosaHydrogen PeroxideOrgan SizeRats, WistarSpleenTime FactorsTooth BleachingTooth Bleaching AgentsThe value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed. Objective: This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals. Material and Methods: Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically signicant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa. Results: The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group. Conclusion: Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.Faculdade de Odontologia de Bauru2015-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109177http://hdl.handle.net/10316/109177https://doi.org/10.1590/1678-775720150235eng1678-7757Paula, Anabela BaptistaDias, Maria IsabelFerreira, Manuel MarquesCarrilho, TeresaMarto, Carlos MiguelCasalta, JoãoCabrita, AntónioCarrilho, Euniceinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-29T15:37:14Zoai:estudogeral.uc.pt:10316/109177Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:22.400147Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats |
title |
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats |
spellingShingle |
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats Paula, Anabela Baptista Ambulatory monitoring Bleaching agents Gastritis Hydrogen peroxide Tooth bleaching Toxicity Animals Body Weight Ethanol Gastric Mucosa Hydrogen Peroxide Organ Size Rats, Wistar Spleen Time Factors Tooth Bleaching Tooth Bleaching Agents Paula, Anabela Baptista Ambulatory monitoring Bleaching agents Gastritis Hydrogen peroxide Tooth bleaching Toxicity Animals Body Weight Ethanol Gastric Mucosa Hydrogen Peroxide Organ Size Rats, Wistar Spleen Time Factors Tooth Bleaching Tooth Bleaching Agents |
title_short |
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats |
title_full |
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats |
title_fullStr |
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats |
title_full_unstemmed |
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats |
title_sort |
Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats |
author |
Paula, Anabela Baptista |
author_facet |
Paula, Anabela Baptista Paula, Anabela Baptista Dias, Maria Isabel Ferreira, Manuel Marques Carrilho, Teresa Marto, Carlos Miguel Casalta, João Cabrita, António Carrilho, Eunice Dias, Maria Isabel Ferreira, Manuel Marques Carrilho, Teresa Marto, Carlos Miguel Casalta, João Cabrita, António Carrilho, Eunice |
author_role |
author |
author2 |
Dias, Maria Isabel Ferreira, Manuel Marques Carrilho, Teresa Marto, Carlos Miguel Casalta, João Cabrita, António Carrilho, Eunice |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Paula, Anabela Baptista Dias, Maria Isabel Ferreira, Manuel Marques Carrilho, Teresa Marto, Carlos Miguel Casalta, João Cabrita, António Carrilho, Eunice |
dc.subject.por.fl_str_mv |
Ambulatory monitoring Bleaching agents Gastritis Hydrogen peroxide Tooth bleaching Toxicity Animals Body Weight Ethanol Gastric Mucosa Hydrogen Peroxide Organ Size Rats, Wistar Spleen Time Factors Tooth Bleaching Tooth Bleaching Agents |
topic |
Ambulatory monitoring Bleaching agents Gastritis Hydrogen peroxide Tooth bleaching Toxicity Animals Body Weight Ethanol Gastric Mucosa Hydrogen Peroxide Organ Size Rats, Wistar Spleen Time Factors Tooth Bleaching Tooth Bleaching Agents |
description |
The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed. Objective: This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals. Material and Methods: Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically signicant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa. Results: The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group. Conclusion: Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109177 http://hdl.handle.net/10316/109177 https://doi.org/10.1590/1678-775720150235 |
url |
http://hdl.handle.net/10316/109177 https://doi.org/10.1590/1678-775720150235 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1678-7757 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1822181690681851904 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1678-775720150235 |