Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease

Detalhes bibliográficos
Autor(a) principal: Bouça-Machado, Raquel
Data de Publicação: 2021
Outros Autores: Branco, Diogo, Fonseca, Gustavo, Fernandes, Raquel, Abreu, Daisy, Guerreiro, Tiago, Ferreira, Joaquim J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50225
Resumo: Copyright © 2021 Bouça-Machado, Branco, Fonseca, Fernandes, Abreu, Guerreiro, Ferreira and The CNS Physiotherapy Study Group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's diseaseParkinson's diseaseDigital healthFunctional mobilityGaitOutcome measuresSensorsTechnologyWearableCopyright © 2021 Bouça-Machado, Branco, Fonseca, Fernandes, Abreu, Guerreiro, Ferreira and The CNS Physiotherapy Study Group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Introduction: Functional mobility (FM) is a concept that incorporates the capacity of a person to move independently and safely to accomplish tasks. It has been proposed as a Parkinson's disease (PD) functional and global health outcome. In this study, we aimed to identify which kinematic and clinical outcomes changes better predict FM changes when PD patients are submitted to a specialized multidisciplinary program. Methods: PD patients engaged in a pre-defined specialized multidisciplinary program were assessed at admission and discharge. Change from baseline was calculated for all kinematic and clinical outcomes, and Timed Up and Go (TUG) was defined as the primary outcome for FM. A stepwise multivariate linear regression was performed to identify which outcome measures better predict TUG changes. Results: Twenty-four patients were included in the study. The changes in TUG Cognitive test, supervised step length, and free-living (FL) step time asymmetry were identified as the best predictors of TUG changes. The supervised step length and FL step time asymmetry were able to detect a small to moderate effect of the intervention (d values ranging from -0.26 to 0.42). Conclusions: Our results support the use of kinematic outcome measures to evaluate the efficacy of multidisciplinary interventions on PD FM. The TUG Cognitive, step length, and FL step time asymmetry were identified as having the ability to predict TUG changes. More studies are needed to identify the minimal clinically important difference for step length and FL step time asymmetry in response to a multidisciplinary intervention for PD FM.The authors would like to acknowledge the support of Fundação para a Ciência e a Tecnologia (FCT) (SFRH/BD/120773/2016 to RB-M; SFRH/BD/144242/2019 to DB, UIDB/00408/2020 and UIDP/00408/2020 to LASIGE).FrontiersRepositório da Universidade de LisboaBouça-Machado, RaquelBranco, DiogoFonseca, GustavoFernandes, RaquelAbreu, DaisyGuerreiro, TiagoFerreira, Joaquim J2021-11-30T15:04:26Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50225engFront Neurol. 2021 Mar 23;12:63762010.3389/fneur.2021.6376201664-2295info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:12Zoai:repositorio.ul.pt:10451/50225Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:38.036600Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease
title Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease
spellingShingle Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease
Bouça-Machado, Raquel
Parkinson's disease
Digital health
Functional mobility
Gait
Outcome measures
Sensors
Technology
Wearable
title_short Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease
title_full Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease
title_fullStr Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease
title_full_unstemmed Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease
title_sort Kinematic and clinical outcomes to evaluate the efficacy of a multidisciplinary intervention on functional mobility in Parkinson's disease
author Bouça-Machado, Raquel
author_facet Bouça-Machado, Raquel
Branco, Diogo
Fonseca, Gustavo
Fernandes, Raquel
Abreu, Daisy
Guerreiro, Tiago
Ferreira, Joaquim J
author_role author
author2 Branco, Diogo
Fonseca, Gustavo
Fernandes, Raquel
Abreu, Daisy
Guerreiro, Tiago
Ferreira, Joaquim J
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bouça-Machado, Raquel
Branco, Diogo
Fonseca, Gustavo
Fernandes, Raquel
Abreu, Daisy
Guerreiro, Tiago
Ferreira, Joaquim J
dc.subject.por.fl_str_mv Parkinson's disease
Digital health
Functional mobility
Gait
Outcome measures
Sensors
Technology
Wearable
topic Parkinson's disease
Digital health
Functional mobility
Gait
Outcome measures
Sensors
Technology
Wearable
description Copyright © 2021 Bouça-Machado, Branco, Fonseca, Fernandes, Abreu, Guerreiro, Ferreira and The CNS Physiotherapy Study Group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-30T15:04:26Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50225
url http://hdl.handle.net/10451/50225
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Neurol. 2021 Mar 23;12:637620
10.3389/fneur.2021.637620
1664-2295
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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