Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/4638 |
Resumo: | The voice is produced by the vibration of vocal cords which are located in the larynx. Therefore, one of the major consequences for patients subjected to laryngectomy is losing their voice. In these cases, a synthetic one-way valve set (voice prosthesis) can be implanted in order to allow restoration of speech. Most voice prostheses are produced with silicone-based materials such as polydimethylsiloxane (PDMS). This material has excellent properties, such as optical transparency, chemical and biological inertness, non-toxicity, permeability to gases and excellent mechanical resistance that are fundamental for its application in the biomedical field. However, PDMS is very hydrophobic and this property causes protein adsorption which is followed by microbial adhesion and biofilm formation. To overcome these problems, surface modification of materials has been proposed in this study. A commercial silicone elastomer, SylgardTM 184 was used to prepare membranes whose surface was modified by grafting 2-hydroxyethylmethacrylate and methacrylic acid by low-pressure plasma treatment. The hydrophilicity, hydrophobic recovery and surface energy of the produced materials were determined. Furthermore, the cytotoxicity and antibacterial activity of the materials were also assessed. The results obtained revealed that the PDMS surface modification performed did not affect the material's biocompatibility, but decreased their hydrophobic character and bacterial adhesion and growth on its surface. |
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Functionalization of polydimethylsiloxane membranes to be used in the production of voice prosthesesPolydimethylsiloxaneVoice prosthesisPlasma surface modificationCell adhesionThe voice is produced by the vibration of vocal cords which are located in the larynx. Therefore, one of the major consequences for patients subjected to laryngectomy is losing their voice. In these cases, a synthetic one-way valve set (voice prosthesis) can be implanted in order to allow restoration of speech. Most voice prostheses are produced with silicone-based materials such as polydimethylsiloxane (PDMS). This material has excellent properties, such as optical transparency, chemical and biological inertness, non-toxicity, permeability to gases and excellent mechanical resistance that are fundamental for its application in the biomedical field. However, PDMS is very hydrophobic and this property causes protein adsorption which is followed by microbial adhesion and biofilm formation. To overcome these problems, surface modification of materials has been proposed in this study. A commercial silicone elastomer, SylgardTM 184 was used to prepare membranes whose surface was modified by grafting 2-hydroxyethylmethacrylate and methacrylic acid by low-pressure plasma treatment. The hydrophilicity, hydrophobic recovery and surface energy of the produced materials were determined. Furthermore, the cytotoxicity and antibacterial activity of the materials were also assessed. The results obtained revealed that the PDMS surface modification performed did not affect the material's biocompatibility, but decreased their hydrophobic character and bacterial adhesion and growth on its surface.Taylor & FrancisuBibliorumFerreira, PaulaCarvalho, ÁlvaroCorreia, Tiago R.Antunes, Bernardo PaivaCorreia, Ilídio Joaquim SobreiraAlves, Patrícia2018-03-20T09:07:29Z2013-09-272013-09-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4638engFerreira, P., Carvalho, A., Correia, T.R., Antunes, B.P., Correia, I.J. e Alves, P. (2013) "Functionalization of polydimethylsiloxane membranes to be used in the production of voice prosthesis", Science and Technology of Advanced Materials, Vol. 14(5), nº do artigo 05500610.1088/1468-6996/14/5/055006metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T02:30:45Zoai:ubibliorum.ubi.pt:10400.6/4638Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:42.021847Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses |
title |
Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses |
spellingShingle |
Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses Ferreira, Paula Polydimethylsiloxane Voice prosthesis Plasma surface modification Cell adhesion |
title_short |
Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses |
title_full |
Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses |
title_fullStr |
Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses |
title_full_unstemmed |
Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses |
title_sort |
Functionalization of polydimethylsiloxane membranes to be used in the production of voice prostheses |
author |
Ferreira, Paula |
author_facet |
Ferreira, Paula Carvalho, Álvaro Correia, Tiago R. Antunes, Bernardo Paiva Correia, Ilídio Joaquim Sobreira Alves, Patrícia |
author_role |
author |
author2 |
Carvalho, Álvaro Correia, Tiago R. Antunes, Bernardo Paiva Correia, Ilídio Joaquim Sobreira Alves, Patrícia |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Ferreira, Paula Carvalho, Álvaro Correia, Tiago R. Antunes, Bernardo Paiva Correia, Ilídio Joaquim Sobreira Alves, Patrícia |
dc.subject.por.fl_str_mv |
Polydimethylsiloxane Voice prosthesis Plasma surface modification Cell adhesion |
topic |
Polydimethylsiloxane Voice prosthesis Plasma surface modification Cell adhesion |
description |
The voice is produced by the vibration of vocal cords which are located in the larynx. Therefore, one of the major consequences for patients subjected to laryngectomy is losing their voice. In these cases, a synthetic one-way valve set (voice prosthesis) can be implanted in order to allow restoration of speech. Most voice prostheses are produced with silicone-based materials such as polydimethylsiloxane (PDMS). This material has excellent properties, such as optical transparency, chemical and biological inertness, non-toxicity, permeability to gases and excellent mechanical resistance that are fundamental for its application in the biomedical field. However, PDMS is very hydrophobic and this property causes protein adsorption which is followed by microbial adhesion and biofilm formation. To overcome these problems, surface modification of materials has been proposed in this study. A commercial silicone elastomer, SylgardTM 184 was used to prepare membranes whose surface was modified by grafting 2-hydroxyethylmethacrylate and methacrylic acid by low-pressure plasma treatment. The hydrophilicity, hydrophobic recovery and surface energy of the produced materials were determined. Furthermore, the cytotoxicity and antibacterial activity of the materials were also assessed. The results obtained revealed that the PDMS surface modification performed did not affect the material's biocompatibility, but decreased their hydrophobic character and bacterial adhesion and growth on its surface. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-27 2013-09-27T00:00:00Z 2018-03-20T09:07:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/4638 |
url |
http://hdl.handle.net/10400.6/4638 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ferreira, P., Carvalho, A., Correia, T.R., Antunes, B.P., Correia, I.J. e Alves, P. (2013) "Functionalization of polydimethylsiloxane membranes to be used in the production of voice prosthesis", Science and Technology of Advanced Materials, Vol. 14(5), nº do artigo 055006 10.1088/1468-6996/14/5/055006 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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