Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/14406 |
Resumo: | The temporomandibular joint disc (TMJd) is an avascular and fibrocartilaginous tissue with low regeneration capacities. To date there is no permanent solution upon its damage. So, our group hypothesise that the combination of a synthetic material [poly(ethylene glycol) diacrylate, PEGDA] and decellularised matrices may be the answer, since it has the advantage of retaining extracellular matrix (ECM) components. For this purpose, lamb TMJd were decellularised with ethanol (96%)/ acetone (99.5%) followed by an analysis to the ECM obtained. Afterwards, different concentrations of ECM powder were added to the PEGDA to obtain hybrid hydrogels. Their swelling capacities and mechanical behaviour (hydrated or dry) were assessed. Results show a reduction of the proteoglycans in the disc, except in the posterior region. Dried hydrogels with 2% ECM powder are the ones with the closer compressive modulus to the native disc, along with greater viscoelastic capacity, representing a possible approach to a TMJd replacement. |
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Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powderDecellularisationExtracellular matrix poderPoly(ethylene glycol) diacrylate hydrogelsTemporomandibular joint discThe temporomandibular joint disc (TMJd) is an avascular and fibrocartilaginous tissue with low regeneration capacities. To date there is no permanent solution upon its damage. So, our group hypothesise that the combination of a synthetic material [poly(ethylene glycol) diacrylate, PEGDA] and decellularised matrices may be the answer, since it has the advantage of retaining extracellular matrix (ECM) components. For this purpose, lamb TMJd were decellularised with ethanol (96%)/ acetone (99.5%) followed by an analysis to the ECM obtained. Afterwards, different concentrations of ECM powder were added to the PEGDA to obtain hybrid hydrogels. Their swelling capacities and mechanical behaviour (hydrated or dry) were assessed. Results show a reduction of the proteoglycans in the disc, except in the posterior region. Dried hydrogels with 2% ECM powder are the ones with the closer compressive modulus to the native disc, along with greater viscoelastic capacity, representing a possible approach to a TMJd replacement.Inderscience PublishersRCIPLTrindade, DanielaMoura, CarlaCalado, CecíliaÂngelo, DavidAlves, Nuno2022-03-08T13:42:56Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14406engTRINDADE, Daniela; [et al] – Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder. World Review of Science, Technology and Sustainable. Development. ISSN 1741-2242. (2022), pp. 1-13.1741-224210.1504/WRSTSD.2022.10044167metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:10:32Zoai:repositorio.ipl.pt:10400.21/14406Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:13.112733Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder |
title |
Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder |
spellingShingle |
Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder Trindade, Daniela Decellularisation Extracellular matrix poder Poly(ethylene glycol) diacrylate hydrogels Temporomandibular joint disc |
title_short |
Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder |
title_full |
Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder |
title_fullStr |
Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder |
title_full_unstemmed |
Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder |
title_sort |
Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder |
author |
Trindade, Daniela |
author_facet |
Trindade, Daniela Moura, Carla Calado, Cecília Ângelo, David Alves, Nuno |
author_role |
author |
author2 |
Moura, Carla Calado, Cecília Ângelo, David Alves, Nuno |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Trindade, Daniela Moura, Carla Calado, Cecília Ângelo, David Alves, Nuno |
dc.subject.por.fl_str_mv |
Decellularisation Extracellular matrix poder Poly(ethylene glycol) diacrylate hydrogels Temporomandibular joint disc |
topic |
Decellularisation Extracellular matrix poder Poly(ethylene glycol) diacrylate hydrogels Temporomandibular joint disc |
description |
The temporomandibular joint disc (TMJd) is an avascular and fibrocartilaginous tissue with low regeneration capacities. To date there is no permanent solution upon its damage. So, our group hypothesise that the combination of a synthetic material [poly(ethylene glycol) diacrylate, PEGDA] and decellularised matrices may be the answer, since it has the advantage of retaining extracellular matrix (ECM) components. For this purpose, lamb TMJd were decellularised with ethanol (96%)/ acetone (99.5%) followed by an analysis to the ECM obtained. Afterwards, different concentrations of ECM powder were added to the PEGDA to obtain hybrid hydrogels. Their swelling capacities and mechanical behaviour (hydrated or dry) were assessed. Results show a reduction of the proteoglycans in the disc, except in the posterior region. Dried hydrogels with 2% ECM powder are the ones with the closer compressive modulus to the native disc, along with greater viscoelastic capacity, representing a possible approach to a TMJd replacement. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-08T13:42:56Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/14406 |
url |
http://hdl.handle.net/10400.21/14406 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
TRINDADE, Daniela; [et al] – Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder. World Review of Science, Technology and Sustainable. Development. ISSN 1741-2242. (2022), pp. 1-13. 1741-2242 10.1504/WRSTSD.2022.10044167 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Inderscience Publishers |
publisher.none.fl_str_mv |
Inderscience Publishers |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133493842673664 |