Enthalpy of solution of terfenadine in ethanol/water mixtures

Detalhes bibliográficos
Autor(a) principal: Canotilho, João
Data de Publicação: 2000
Outros Autores: Costa, Felisbela S., Sousa, Adriano T., Redinha, J. Simões, Leitão, M. Luísa P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5813
https://doi.org/10.1016/s0040-6031(99)00319-6
Resumo: The enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol-1 in the enthalpy at a concentration value around 0.01 mol kg-1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determined.
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spelling Enthalpy of solution of terfenadine in ethanol/water mixturesCrystal designCrystallizationPolymorphismSolubilitySolute self-aggregationSolution enthalpyTerfenadineThe enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol-1 in the enthalpy at a concentration value around 0.01 mol kg-1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determined.http://www.sciencedirect.com/science/article/B6THV-3Y9X8C1-3/1/946cc8e5c8724eb5cab7f1c41b09d0f72000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5813http://hdl.handle.net/10316/5813https://doi.org/10.1016/s0040-6031(99)00319-6engThermochimica Acta. 344:1-2 (2000) 9-13Canotilho, JoãoCosta, Felisbela S.Sousa, Adriano T.Redinha, J. SimõesLeitão, M. Luísa P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-11-02T09:32:36Zoai:estudogeral.uc.pt:10316/5813Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:19.129455Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Enthalpy of solution of terfenadine in ethanol/water mixtures
title Enthalpy of solution of terfenadine in ethanol/water mixtures
spellingShingle Enthalpy of solution of terfenadine in ethanol/water mixtures
Canotilho, João
Crystal design
Crystallization
Polymorphism
Solubility
Solute self-aggregation
Solution enthalpy
Terfenadine
title_short Enthalpy of solution of terfenadine in ethanol/water mixtures
title_full Enthalpy of solution of terfenadine in ethanol/water mixtures
title_fullStr Enthalpy of solution of terfenadine in ethanol/water mixtures
title_full_unstemmed Enthalpy of solution of terfenadine in ethanol/water mixtures
title_sort Enthalpy of solution of terfenadine in ethanol/water mixtures
author Canotilho, João
author_facet Canotilho, João
Costa, Felisbela S.
Sousa, Adriano T.
Redinha, J. Simões
Leitão, M. Luísa P.
author_role author
author2 Costa, Felisbela S.
Sousa, Adriano T.
Redinha, J. Simões
Leitão, M. Luísa P.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Canotilho, João
Costa, Felisbela S.
Sousa, Adriano T.
Redinha, J. Simões
Leitão, M. Luísa P.
dc.subject.por.fl_str_mv Crystal design
Crystallization
Polymorphism
Solubility
Solute self-aggregation
Solution enthalpy
Terfenadine
topic Crystal design
Crystallization
Polymorphism
Solubility
Solute self-aggregation
Solution enthalpy
Terfenadine
description The enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol-1 in the enthalpy at a concentration value around 0.01 mol kg-1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determined.
publishDate 2000
dc.date.none.fl_str_mv 2000
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5813
http://hdl.handle.net/10316/5813
https://doi.org/10.1016/s0040-6031(99)00319-6
url http://hdl.handle.net/10316/5813
https://doi.org/10.1016/s0040-6031(99)00319-6
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Thermochimica Acta. 344:1-2 (2000) 9-13
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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